Current Pharmacological Trends on Myricetin

Abstract

Myricetin is a member of the group of flavonoids called flavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other flavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inflammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer’s disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.

Myricetin 3-O-β-D-Galactopyranoside Exhibits Potential Anti-Osteoporotic Properties in Human Bone Marrow-Derived Mesenchymal Stromal Cells via Stimulation of Osteoblastogenesis and Suppression of Adipogenesis

“…Plant-based nutraceuticals can be found in common dietary sources in various forms and derivatives which may show different and/or more efficient bioactivities. Myricetin is a common phytochemical which is intensively studied for its bioactivities and still provides novel outcomes in terms of efficiency and effectiveness [10,17,18]. Therefore, derivatives of myricetin are also receiving increasing interest in this context where their potential bioactivities, action mechanisms, adverse effects, etc., are being continuously explored.…”

Cyperus Iria Aqueous-Ethanol Extract Ameliorated Hyperglycemia, Oxidative Stress and Regulated Inflammatory Cytokines in Streptozotocin Induced Diabetic Rats

“…Many studies have reported that this genus possess antioxidant effect probably by controlling the over production of free radicals. The reduction in glucose level might be attributed to the detected myrecetin as it is responsible for the inhibition of I-kappa-B(IkB)/nuclear factor-kB (NF-KB) P65 signaling pathway (Gupta et al 2020). Myrecetin also possess the ability to alter phosphorylation of insulin receptor, subsequently effecting glucose transporters sub type 4 (GLUT-4) translocation (Li and Ding 2012).It also possess the potential to protect the beta cells against high glucose induced apoptosis by inhibition of endoplasmic stress probably by inactivation of CDK5 and subsequent upregulation of PDX-1 and SER CA2b (Gupta et al 2020).…”

Network Pharmacology Integrated Molecular Docking Reveals the Mechanism of Zhongfeng Xingnao Formula against Intracerebral Hemorrhage

“…Beta-sitosterol were proved to be effective in ICH mainly by reducing the risk of plasma cholesterol and atherosclerosis [40]. Several pharmacological properties on Mandenol have been reported including attenuating the expression of pro-in ammatory factors [41], Gudiya et al have shown that Myricanone was equipped with the biological functions of antioxidant, antiin ammatory, and anti-ischemia-reperfusion injury [42]. In addition, aloe-emodin is a widely existing anthraquinone in nature, which has been found to lower cholesterol by inhibiting PCSK9 [43].…”