Present study is involved in identification of biophenolic and flavonoids from the aqueous-ethanol extract of Cyperus iria and appraisal of inflammatory and stress markers involved in endocrine dysfunction based upon its folktale use. Significantly higher quantities of phenolic (82.79 ± 0.003 mg/g GAE) and flavonoid (13.61 ± 0.002 mg/g QE) contents were present. Inhibitory concentration (IC50) exhibited an excellent potential for both antioxidant (IC50 = 3.22 µg/mL) and alpha amylase (IC50 = 36.29 µg/mL) inhibitory assays. High performance liquid chromatography (HPLC), confirmed the existence of myercetin, quercetin, kaempferol and ferullic acid. Cyperus iria aqueous-ethanol extract exhibits good tolerance against glucose. Streptozotocin induced hyperglycemia declined along with improvement in inflammatory (TNF-α = 15.6 ± 0.2 g/l, COX-2 = 357 ± 0.396 U/l, IL-6 = 572 ± 0.99 pg/l) and oxidative stress markers (SOD = 163 ± 0.616 and GSH-ST = 95.8 ± 0.44 U/mL) along with biochemical parameters in a dose-dependent manner. Present study suggests that Cyperus iria aqueous-ethanol extract possess hypoglycemic potential which might be attributed to the presence of phenolics and flavonoids.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.