Current pesticide profiles in blood serum of adults in Jiangsu Province of China and a comparison with other countries

Chang, Chengkang; Chen, Minjian; Gao, Jiawei; Luo, Jia; Wu, Kaigui; Dong, Tianyu; Zhou, Kun; He, Xiaowei; Hu, Wu; Wu, Wei; Lu, Chuncheng; Hang, Bo; Meeker, John D.; Wang, Xinru; Xia, Yankai

doi:10.1016/j.envint.2017.03.004

Cited by 52 publications

(21 citation statements)

References 43 publications

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“…Although the production and use of many pesticides tested in this study, with the exception of propanil, vinclozolin, quintozene and phosalone, have been reduced or eliminated in China (http://www.icama.org.cn/), these compounds can still be detected in the environment, animal and human tissues [22][23][24][25].…”

Section: Discussionmentioning

confidence: 97%

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Xu¹,

Yang²,

Qian³

et al. 2020

Preprint

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Background: There is evidence that genetic and environmental factors contribute to the onset and progression of Parkinson’s disease (PD). Pesticides are a class of environmental toxins that are linked to increased risk of PD. However, few studies have investigated the interaction between specific pesticides and genetic variants related to PD in the Chinese population.Methods: In this cross-sectional study, 19 serum levels of pesticides were measured. In addition, we also analyzed the interaction between specific pesticides and candidate genetic variants for PD. Finally, we investigated the mechanistic basis for the association between pesticides and increased risk of PD.Results: Serum levels of organochlorine pesticides including α-hexachlorocyclohexane (α-HCH), β-HCH, γ-HCH, δ-HCH, propanil, heptachlor, dieldrin, hexachlorobenzene, p,p’-dichlorodiphenyltrichloroethane (p,p’-DDE) and o,p’-dichloro-diphenyl-trichloroethane (o,p’-DDT) were higher in PD patients than in controls. α-HCH and propanil levels were associated with increased PD risk. Serum levels of dieldrin were associated with Hamilton Depression Scale and Montreal Cognitive Assessment scores in PD patients. The interaction between rs11931074 in α-synuclein (SNCA) and α-HCH or β-HCH, respectively, as well as rs16940758 in the microtubule-associated protein tau (MAPT) gene and δ-HCH were related to increased risk of PD. In addition, α-HCH and propanil enhanced the production of reactive oxygen species and decreased of mitochondrial membrane potential. Propanil but not α-HCH induced the aggregation of α-synuclein.Conclusions: Elevated serum levels of α-HCH and propanil are associated with increased risk of PD. Serum levels of dieldrin were associated with depression and cognitive function in PD patients. The interaction between genetic variants and pesticides also increased the risk of PD. Effects of genetic variants and pesticides on the risk of PD should be studied in more detail with a larger sample size to further understand the mechanisms involved.

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Section: Discussionmentioning

confidence: 97%

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Xu¹,

Yang²,

Qian³

et al. 2020

Preprint

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“…Specifically, Chang et al. detected AZ in blood from 3% (6/200) of the participants (adult population in China) with a concentration that ranged from

( Chang et al. 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our study participants were sampled in the United States and samples were collected more recently than in the Chang et al. study ( Chang et al. 2017 ), which could contribute to higher detection frequency and concentration.…”

Section: Discussionmentioning

confidence: 99%

Detection of Azoxystrobin Fungicide and Metabolite Azoxystrobin-Acid in Pregnant Women and Children, Estimation of Daily Intake, and Evaluation of Placental and Lactational Transfer in Mice

Liu

Jiménez

et al. 2022

Environ Health Perspect

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Background: Azoxystrobin (AZ) is a broad-spectrum strobilurin fungicide that is used in agriculture and was recently added to mold- and mildew-resistant wallboards. AZ was found to have toxic effects in animals at embryonic stages and was listed as a frontline target for biomonitoring in children. Objectives: This study investigated exposure to AZ in pregnant women and young children, whether AZ could be transferred from an exposed mother to offspring, and whether AZ or one of its primary metabolites, AZ-acid, was neurotoxic in vitro . Methods: We quantified AZ-acid, a sensitive indicator of AZ exposure, in urine samples collected from 8 pregnant women (12 urine samples) and 67 children (40–84 months old; 96 urine samples) with high-resolution mass spectrometry. Gestational and lactational transfer was assessed in C57Bl/6 mice. Neurotoxicity of AZ and AZ-acid was investigated in vitro with mouse cortical neuron cultures. Results: AZ-acid was present above the limit of quantification ( ) in 100% of the urine samples from pregnant women and in 70% of the urine samples from children, with median concentration of 0.10 and , and maximal concentration of 2.70 and , respectively. Studies in mice revealed that AZ transferred from the mother to offspring during gestation by crossing the placenta and entered the developing brain. AZ was also transferred to offspring via lactation. High levels of cytotoxicity were observed in embryonic mouse cortical neurons at concentrations that modeled environmentally relevant exposures. Discussion: Our study suggested that pregnant women and children were exposed to AZ, and at least 10% of the children (2 out of 20 that were evaluated at two ages) showed evidence of chronic exposure. Future studies are warranted to evaluate whether chronic AZ exposure affects human health and development. https://doi.org/10.1289/EHP9808

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“…Edifenphos contributed to 24.10%, 12.64%, 12.94%, 9.48%, 13.89%, and 11.14% HI, whereas disulfoton-sulfone contributed 10.55%, 10.36%, 14.05%, 8.86%, 14.70%, and 10.80% HI for the GReR, PQR, PR, SMReR, CR, and GR samples, respectively. Edifenphos has been detected in the blood serum of 19% of adults surveyed in Jiangsu Province (Chang et al, 2017). Further investigation of pesticide accumulation in organisms is strongly recommended to analyze the cumulative health risks.…”

Section: Cumulative Risk Assessmentmentioning

confidence: 99%

Analysis of dietary exposure and risk assessment of pesticide residues in roots and rhizomes of Chinese herbs

Xie

Zhao

et al. 2021

Journal of Food Science

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Medicine food homologous (MFH) plants provide therapeutic and health care effects through diet. Thus, a risk assessment system for hazardous ingredient residues is urgently required to ensure their safe use. In this study, the pesticide contamination of six root and rhizome Chinese herbs, Ginseng Radix et Rhizoma, Panacis Quinquefolii Radix, Pseudostellariae Radix, Salviae Miltiorrhizae Radix et Rhizoma, Codonopsis Radix, and Glehniae Radix, and the risks associated with their intake were investigated. A total of 420 MFH plant samples collected from 22 provinces in China were tested, and 61 pesticides were detected in 413 samples. Multiple pesticide residues were detected in each MFH sample, with contents ranging from 0.0002 to 3.010 mg/kg dry weight. Carbendazim (≥47.14%) and propham (≥40%) were the most frequently detected pesticides. Risk assessment determined by hazard quotients indicated that the risks were acceptable, with no short-or long-term adverse health effects. However, considering the high incidence of residues and the detection of unregistered or even prohibited pesticides, strict supervision of soil quality and pesticide application (particularly cadusafos) in MFH plant cultivation are recommended to aid in monitoring MFH plant quality and ensuring diet and drug safety.

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Current pesticide profiles in blood serum of adults in Jiangsu Province of China and a comparison with other countries

Cited by 52 publications

References 43 publications

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Detection of Azoxystrobin Fungicide and Metabolite Azoxystrobin-Acid in Pregnant Women and Children, Estimation of Daily Intake, and Evaluation of Placental and Lactational Transfer in Mice

Analysis of dietary exposure and risk assessment of pesticide residues in roots and rhizomes of Chinese herbs

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