Current Perspectives on the Dissolution Stability of Solid Oral Dosage Forms

Murthy, K. S. Keshava; Ghebre-Sellassie, Isaac

doi:10.1002/jps.2600820202

Cited by 64 publications

(24 citation statements)

References 61 publications

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“…The requirement of sustained release dosage form is shown Table 1 [17]. Therefore, to increase the release of amoxicillin, amoxicillin was prepared in solid dispersion form.…”

Section: Antibacterial Activities Assessmentmentioning

confidence: 99%

Floating Gastroretentive of Amoxicillin Using Hard Alginate Capsules and Its Antibacterial Activities

Bangun

Arianto

Yohana

et al. 2017

Asian J Pharm Clin Res

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Objective: The aim of this study was to formulate the floating gastroretentive of amoxicillin using hard alginate capsules shell and evaluate the antibacterial activities of floating gastroretentive of amoxicillin.Methods: Amoxicillin was prepared in the solid dispersion form, it was prepared by a solvent method using polyvinylpyrrolidone (PVP) K30.The solid dispersion was characterized by X-ray diffraction and Fourier transformed infra-red analysis. The drug was filled into alginate capsule shell. Drug release test was carried out using USP paddle method in simulated gastric fluid. Concentrations of amoxicillin were determined using spectrophotometer ultraviolet at wavelength of 272 nm. The antibacterial activity of aliquots dissolution was assessed using agar plate diffusion method against Staphylococcus aureus and Escherichia coli as bacterial model. Results:The dissolution test results showed that amoxicillin in the solid dispersions form with a weight ratio of amoxicillin and PVP K30 was 1:1 caused sustained release of amoxicillin for 12 hrs, while the release of amoxicillin without solid dispersion was too slow. The floating lag time was 0 minute and floating time was more than 12 hrs. The X-ray diffraction pattern of amoxicillin solid dispersion had amorphous shape. Antibacterial activity test showed that the dissolution aliquots of amoxicillin solid dispersion were effective against S. aureus and E. coli. Conclusions:Based on the results of this study, it is concluded that the alginate capsules shell can be used for the preparation of floating gastroretentive of amoxicillin using amoxicillin solid dispersion and the dissolution aliquots give antibacterial effect.

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“…The requirement of sustained release dosage form is shown Table 1 [17]. Therefore, to increase the release of amoxicillin, amoxicillin was prepared in solid dispersion form.…”

Section: Antibacterial Activities Assessmentmentioning

confidence: 99%

Floating Gastroretentive of Amoxicillin Using Hard Alginate Capsules and Its Antibacterial Activities

Bangun

Arianto

Yohana

et al. 2017

Asian J Pharm Clin Res

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“…Hal tersebut dapat mempengaruhi laju disolusi obat. 16 Penelitian ini bertujuan untuk mengetahui stabilitas disolusi kapsul piroksikam yang telah dimodifikasi dengan rekristalisasi dan pembentukan dispersi padat dengan pembawa PEG 6000. Pembawa PEG 6000 paling banyak dipakai sebagai pembawa dispersi padat dan terbukti memberikan tingkat peningkatan kecepatan disolusi piroksikam yang lebih tinggi dibandingkan polimer yang lain.…”

Section: 2unclassified

Disolusi Kapsul Dispersi Padat Piroksikam-PEG 6000 Selama Penyimpanan

Binarjo

Khotimah²

2017

IJPST

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AbstrakKelarutan piroksikam yang rendah mempengaruhi laju disolusi sebagai penentu bioavaibilitas. Pembuatan dispersi padat dengan piroksikam-polietilenglikol dapan meningkatkan laju disolusinya. Tujuan penelitian ini adalah untuk mengetahui pengaruh pembentukan dispersi padat piroksikampolietilenglikol 6000 (PEG 6000) terhadap laju disolusi kapsul piroksikam selama 1 bulan penyimpanan. Rekristal piroksikam (R) dan dispersi padat piroksikam-PEG 6000 (DP) dibuat dengan metode pelarut menggunakan campuan aseton-etanol (1:1), keduanya bersama dengan piroksikam tanpa modifikasi (P) dikapsul dan disimpan selama 1 bulan. Uji disolusi dilakukan setiap minggu. Efisiensi disolusi 60 menit (DE60), prosentase disolusi 45 menit (C45), dan waktu untuk 80% terdisolusi (t80) digunakan sebagai parameter disolusi. Kurva hubungan DE60, C45, dan t80 terhadap waktu penyimpanan dilihat slopenya sebagai parameter stabilitas. Hasil percobaan menunjukkan bahwa Kapsul P dan DP menunjukkan nilai DE60, C45, dan t80 yang stabil selama penyimpanan (slope=0, p>0.05), demikian juga nilai t80 kapsul R. Sedangkan DE60 dan C45 kapsul R selama penyimpanan terus menurun dengan slope -0,636 %/hari dan -0,171 mg/hari. Dapat disimpulkan bahwa DP yang dibuat dengan metode pelarut campuran aseton dan etanol (1:1) menunjukkan profil disolusi yang stabil selama penyimpanan 1 bulan.. Kata kunci : disolusi, piroksikam, dispersi padat, polietilenglikol 6000, stabilitas Dissolution Of Solid Dispersion Piroxicam-PEG 6000 Capsules During Storage AbstractThe low solubility of piroxicam affect its rate of dissolution as bioavailability limiting factor. Solid dispersion using polyethilenglycol can improve its dissolution rate. This research was aimed to determine the effect of piroxicam-polyethylenglycol 6000 (PEG 6000) solid dispersion formation on the dissolution rate of piroxicam capsules during storage for 1 month. The piroxicam recrystal (R) and solid dispersion of piroxicam-PEG 6000 (DP) were prepared by solvent method using acetone-ethanol (1:1), these two bulk and unmodified piroxicam (P) as control than be capsulated and stored for 4. Their dissolution were tested every week. Sixty minutes dissolution efficiency (DE60), percent drug dissolved in 45 minutes (C45), and time to dissolve 80% of drug (t80) were used as dissolution parameters. The slope of the plot of these dissolution parameters as a function of time storage was used as a stability indicator. The result show that P and DP capsules have a constant DE60, C45, and t80 during storage (slope=0, p>0.05), also the data of t80 of R capsule. DE60 and C45 of R capsule is going lower during the storage with the slope of -0,636 %/day and -0,171 mg/day. It can be concluded that DP prepared by solvent method using acetoneethanol (1:1) shows the stable dissolution profiles during storage for 1 month.

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“…During the storage, the gastro-resistant dosage forms are subjected to physical and chemical alterations than can modify the lioavailabity and bioavailability of drugs (18,19). Paying attention to these considerations, residual formaldehyde, disintegration, and dissolution tests were determined on capsules, immediately after coating and at the end of 1, 2, 3, and 6 months of holding the capsules packed in plastic bottles, well stoppered, at 37 C and a relative humidity of 20-25%, or at ambient temperature and a relative humidity of 40-50%.…”

Section: Stability Studiesmentioning

confidence: 99%