Current Paradigms in COVID-19 Research: Proposed Treatment Strategies, Recent Trends and Future Directions

Abstract

<jats:sec> <jats:title>Background:</jats:title> <jats:p> Recent pandemic of coronavirus disease caused by a novel coronavirus SARS-CoV-2 in humans is the third outbreak by this family of viruses leading to an acute respiratory infection which has been a major cause of morbidity and mortality worldwide.The virus belongs to the genus, Betacoronavirus which has been recently reported to have significant similarity (&gt;89%) to a severe acute respiratory syndrome (SARS)-related member of the Sarbecoviruses. Current researches are not sufficient to understand the etiological and immunopathobiological parameters related to COVID-19 so as to have a therapeutic solution to the problem.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p> A structured search of bibliographic databases for peer-reviewed research literature has been carried out using focused review questions and inclusion/exclusion criteria. Further Standard tools were implied in order to appraise the quality of retrieved papers. The characteristic outcomes of screened research and review articles along with analysis of the interventions and findings of included studies using a conceptual framework have been described employing a deductive qualitative content analysis methodology.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>This review systematically summarizes the immune-pathobiological characteristics, diagnosis, potential therapeutic options for the treatment and prevention of COVID-19 based on the current published literature and evidence. The current review has covered 125 peer-reviewed articles, majority of which are from high-income technically developed countries providing the most recent updates about the current understanding of the COVID-19 bringing all the significant findings and related researches together at a single platform. In addition, possible therapeutic interventions, treatment strategies and vaccine development initiatives to manage COVID-19 have been proposed.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p> It is anticipated that this review would certainly assist the public in general and scientific community in particular to recognize and effectively deal with COVID-19, providing a reference guide for futuristic studies. </jats:p> </jats:sec>

Myocardial Infarction Following COVID-19 Vaccine Administration: Post Hoc, Ergo Propter Hoc?

“…In the last 2 years, several RCTs and observational studies have confirmed that a global vaccination against COVID-19 is the most effective and safest strategy in order to contain the pandemic [25][26][27][28]. AEs after a COVID-19 vaccination are very rare.…”

Multifaceted antiviral therapeutic potential of dietary flavonoids: Emerging trends and future perspectives

“…5,6 Considering the broad-spectrum antiviral role of the flavonoids, this review emphasizes upon the bioactive potential of major flavonoids against viral diseases including the prevailing pandemic of coronavirus disease 2019 (COVID-19). 7…”

“…Flavonoids are actually composed of a group of secondary metabolites found in vegetables, fruits, spices, red wine, and in tea as well, which play a defensive role against plant pathogens and insects 5,6 . Considering the broad‐spectrum antiviral role of the flavonoids, this review emphasizes upon the bioactive potential of major flavonoids against viral diseases including the prevailing pandemic of coronavirus disease 2019 (COVID‐19) 7 …”

Acceptance and Attitudes of North Indian Population Towards COVID-19 Vaccines

“…People afflicted with this disease have mild to moderate symptoms and the same recover without any special treatment. While on the other hand, some of the patients become seriously ill requiring medical attention (Sharma et al, 2021). Most of the infected people experience mild to moderate respiratory problems or illnesses and also it has been seen that they recover without any special medication/treatment (Sharma et al, 2022).…”