Multifaceted antiviral therapeutic potential of dietary flavonoids: Emerging trends and future perspectives

Abstract

Phytochemicals are the natural biomolecules produced by plants via primary or secondary metabolism, which have been known to have many potential health benefits to human beings. Flavonoids or phytoestrogens constitute a major group of such phytochemicals widely available in variety of vegetables, fruits, herbs, tea, and so forth, implicated in a variety of bio‐pharmacological and biochemical activities against diseases including bacterial, viral, cancer, inflammatory, and autoimmune disorders. More recently, these natural biomolecules have been shown to have effective antiviral properties via therapeutically active ingredients within them, acting at different stages of infection. Current review emphasizes upon the role of these flavonoids in physiological functions, prevention and treatment of viral diseases. More so the review focuses specifically upon the antiviral effects exhibited by these natural biomolecules against RNA viruses including coronaviruses. Furthermore, the article would certainly provide a lead to the scientific community for the effective therapeutic antiviral use of flavonoids using potential cost‐effective tools for improvement of the pharmacokinetics, bioavailability, and biodistribution of such compounds for the concrete action along with the promotion of human health.

In-silico designing of a potent ligand molecule against PTEN (Phosphatase and tensin homolog) implicated in Breast Cancer

“…The designed models were then refined using PROCHECK (Wiederstein and Sippl 2007), which revealed model 1 as the most stable structure with significant core residues (Figure 1A). Further, the complete quality examination by Z-score (-12.46) indicated that the obtained model was significantly close to the template (Sharma et al 2021c). As per the literature review, Histidine (HIS) at 123 positions, Lysine (LYS) at 125 positions, Glycine (GLY) at 127 positions, and Lysine (LYS) at 128 positions) formed the active site (Figure 1B) (Sharma et al 2020c).…”

A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation

“…Likewise, aging is also a progressive decline process with the accumulation of gene mutations and cellular-level epigenetic modifications, which may ultimately result in the development of aging-associated diseases including colon cancer (Zabransky et al 2022 ). Quercetin, a glycoside, has a high medicinal value, involved in a variety of cellular activities including anti-aging, cardiovascular, anti-inflammation, and anti-cancer activities (Salehi et al 2020 ; Sharma et al 2021 ). Hence, quercetin among the flavonoids is thought to have potential bioactivity as medicinal usage for cancer therapy.…”

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

“…Pharmacologically, flavonoids are excellent antiviral and neuroprotective agents with proven therapeutic effects on various viral (deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) viruses) and neurological diseases [ 61 , 62 ]. Numerous preclinical studies have revealed the ability of flavonoids to affect several steps of the viral life cycle of different viruses, including herpesviruses [ 63 , 64 , 65 ]. The potent antiviral actions of flavonoids relate to the diversity of their chemical structures.…”