Current overview of pregnancy complications and live-birth outcome of assisted reproductive technology in mainland China

Yang, Xiaokui; Li, Ying; Li, Changdong; Zhang, Weiyuan

doi:10.1016/j.fertnstert.2013.10.017

Cited by 92 publications

(85 citation statements)

References 23 publications

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“…Assisted reproductive technology (ART) has been increasingly used to treat couples with infertility in the past 30 years . Up to 4% of infants were born as the consequence of ART treatments in developed countries, and the percentage was about 1% in China in 2011 . One of the major detrimental outcomes of ART treatment is the high incidence of multiple births, mostly twins, because of advanced maternal age and implantation of multiple embryos.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Up to 4% of infants were born as the consequence of ART treatments in developed countries, and the percentage was about 1% in China in 2011. 3 One of the major detrimental outcomes of ART treatment is the high incidence of multiple births, mostly twins, because of advanced maternal age and implantation of multiple embryos. Various studies showed that 20-30% of ART-related live birth were twins comparing to 1.6% of natural conception.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

et al. 2016

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“…There is conflicting evidence regarding the occurrence of fetal growth restriction in assisted conceptions, most likely because it is difficult to define and, prior to 2016, there was no consensus. 61 Several cohort studies and meta-analyses have reported that fetal growth can be reduced, 36,62,63 but most use low birthweight as evidence of growth restriction rather than serial scan measurements demonstrating a tailing-off of fetal growth. The increased rates of fetal growth restriction observed are most commonly attributed to abnormal placentation.…”

Section: Growth Restrictionmentioning

confidence: 99%

“…Pregnancies conceived following ART are at increased risk of PTL. 36,40,62,63,73 One study including approximately 4500 singleton pregnancies resulting from ART reported incidences of very PTL (before 32 weeks of gestation) and PTL (before 37 weeks of gestation) of 2.6% and 11.2%, respectively, compared with 0.7% and 5.4% in the general population. 49 This increase in risk, which is estimated to be at least double that occurring in spontaneously conceived pregnancies, is of similar magnitude to a mother with a previous history of PTL.…”

Section: Preterm Labourmentioning

confidence: 99%

Antenatal management of singleton pregnancies conceived using assisted reproductive technology

Richardson

Taylor

Teoh³

et al. 2019

The Obstetric & Gynaecologis

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Use of assisted reproductive technology (ART) to achieve conception is increasing worldwide, and while the majority of resulting pregnancies will have a normal outcome, not all do. Assisted conceptions are at increased risk of maternal and fetal complicationsmany of which may be underappreciated or indeed overappreciated by those who go on to look after pregnant women. Healthcare professionals involved in the antenatal care of women who have conceived using ART must understand the potential risks, their significance and how best to monitor them. Learning objectives To understand the maternal complications associated with ART, including ovarian hyperstimulation syndrome, miscarriage, ectopic pregnancy, pregnancy-induced hypertension, pre-eclampsia, gestational diabetes and venous thromboembolism. To understand the fetal complications associated with ART, including genetic and chromosomal disorders, structural abnormalities, growth restriction, stillbirth and preterm labour. To establish an evidence-based approach to the antenatal management of singleton pregnancies conceived using ART.

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“…Assisted reproductive technology (ART) has been an effective infertility treatment for nearly three decades; however, the efficiency of ART is still low. [1][2][3] Improving ART efficiency is a problem for obstetricians and gynecologists; therefore, many clinics offer the transfer of a single blastocyst, which resembles the physiological process, to improve the efficiency of clinical pregnancy and to avoid multiple gestations. [4][5][6] As a result of ovarian stimulation, more than one mature egg can be obtained in each in vitro fertilization (IVF) cycle.…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐6 regulates expression of Fos and Jun genes to affect the development of mouse preimplantation embryos

Yu¹,

Zhang²,

Wang³

et al. 2017

J of Obstet and Gynaecol

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AimWe investigated whether recombinant mouse interleukin‐6 (IL‐6) affects the development of preimplantation embryos and induces the ‐signal transducers and activators of transcription (JAK–STAT) signaling pathway by binding IL‐6 signal transducer (IL‐6st) and regulating Fos and Jun gene expression, thereby accounting for the negative effect of superovulation on embryo development.MethodsWe compared rates of blastocyst formation from embryos cultured with different concentrations of IL‐6 or/and anti‐interleukin 6 receptor antibody (anti‐IL‐6RAb) in superovulated experimental and normal control groups. IL‐6 expression in preimplantation embryos was determined by immunofluorescence identification. Fos, Jun and IL‐6st messenger RNA expression was detected by PCR and microarray experiments.ResultsRates of blastocyst formation significantly decreased in superovulated embryos, whether or not they were incubated in 0.1, 1, 25 or 50 pg/mL IL‐6, (P < 0.01) compared to embryos from naturally ovulated controls, whereas incubation in 5 and 10 pg/mL IL‐6 reversed the negative effects of superovulation. The addition of anti‐IL‐6RAb to naturally ovulated embryos reduced blastocyst rates to those of superovulated embryos. Gene chip analysis indicated that the JAK–STAT signaling pathway contained differentially expressed IL ‐6, IL ‐6st, Jun and Fos genes. Both anti‐IL‐6RAb or ovarian stimulation downregulated IL‐6st, Jun, and Fos messenger RNA expression, but expression of the same three genes increased in 5 pg/mL IL‐6.ConclusionOvarian stimulation negatively impacts the development of preimplantation embryos by reducing IL‐6 release. IL‐6 affects the rate of development of zygotes to blastocyst by regulating IL ‐6st, F os and J un expression in the JAK–STAT signaling pathway.

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Current overview of pregnancy complications and live-birth outcome of assisted reproductive technology in mainland China

Cited by 92 publications

References 23 publications

Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

Antenatal management of singleton pregnancies conceived using assisted reproductive technology

Interleukin‐6 regulates expression of Fos and Jun genes to affect the development of mouse preimplantation embryos

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