Current medical therapy for ulcerative colitis

Xu, Cheng

doi:10.3748/wjg.v5.i1.64

Cited by 14 publications

(7 citation statements)

References 25 publications

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“…DEX suppresses the inflammatory reaction via activation of transcription factor NF-kB [22]. DEX is beneficial in IBD patients with severe symptoms; however, severe side effects limit its use, particularly for long term therapy [23]. RTP is a high MW polysaccharide (∼3×10 6 Da).…”

Section: Discussionmentioning

confidence: 99%

The beneficial effect of Rheum tanguticum polysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: The role of macrophage mannose receptor in inflammation and immune response

Liu

Guo

et al. 2008

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

The beneficial effect of Rheum tanguticum polysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: The role of macrophage mannose receptor in inflammation and immune response

Liu

Guo

et al. 2008

International Immunopharmacology

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“…DEX is one of the most widely used drugs for treatment of AAU in clinic; however, severe systemic and ocular side effects limit its use, particularly for long term therapy [6]. Preclinical and clinical studies have demonstrated that Rheum polysaccharides exhibited numerous beneficial therapeutic properties, including immunostimulation, antiinfection, antitumor, and other therapeutic aspects [7–9].…”

Section: Discussionmentioning

confidence: 99%

Role of Rheum Polysaccharide in the Cytokines Produced by Peripheral Blood Monocytes in TLR4 Mediated HLA-B27 Associated AAU

Liu

Zhang

et al. 2013

BioMed Research International

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Purpose. To evaluate the effect of a traditional Chinese medicine, Rheum Polysaccharide (RP), on the in vitro production of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) by lipopolysaccharide- (LPS-)stimulated human monocytes from HLA-B27 associated acute anterior uveitis patients of convalescence stage. Method. PBMC samples were isolated from 10 HLA-B27 associated acute anterior uveitis, incubated, respectively, and divided into 4 groups as follows: (1) controls, PBS was added in final concentration of 1 mg·L−1, (2) stimulated by LPS, LPS was added in final concentration of 1 mg·L−1, (3) stimulated by LPS + HTA125, 30 minutes before the adding of LPS in final concentration of 1 mg·L−1, the final concentration of 5 mg·L−1 of the HTA125 was added, and (4) stimulated by LPS + RP, 30 minutes before the adding of LPS in final concentration 1 mg·L−1, the final concentration 100 mg·L−1 of the RP was added. Supernatants were used to quantify the amounts of TNF-α and IL-10 released in time course using enzyme-linked immunosorbent assay (ELISA). Result. After stimulated by lps, the concentrations of TNF-α and IL-10 in culture supernatants of patients are significantly higher than control group at all time points (P < 0.01). Blockage of TLR-4 by HTA125 can decrease the production of TNF-α and IL-10 compared with lps group (P < 0.01, except at 4 h group of IL-10). Concentration of TNF-α and IL-10 also decreases in the LPS + RP group (P < 0.01) but not so significantly as in the LPS + HTA125 group. Conclusion. As anti-TLR4 monoclonal antibodies, rheum Polysaccharide can also inhibit the secretion of cytokines produced by monocytes from HLA-B27 positive AAU patients of convalescence stage.

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“…They may also be used in conjunction with other medications as a means to induce remission. These, too, are only for short-term use [2,8]. MEDLINE, EMBASE, and the Cochrane central register of controlled trials were searched (through December 2010) by Ford et al [26].…”

Section: Corticosteroidsmentioning

confidence: 99%

“…In addition to controlling inflammation, some medications may help relieve the signs and symptoms. Depending on the severity of UC, the patients are recommended one or more of the following [2,8,[18][19][20][21]. Antidiarrheals: A fiber supplement such as psyllium powder (Metamucil) or methylcellulose (Citrucel) can help relieve signs and symptoms of mild to moderate diarrhea by adding bulk to the stool.…”

Section: Treatment Of Traditional Chinese Medicinementioning

confidence: 99%