Current Epidemiology and Outcome of Infective Endocarditis

Abstract

The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE).From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals.Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55–77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44).IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.

Characteristics of Infective Endocarditis in a Tertiary Hospital in East China

“…The in-hospital mortality for IE has not improved, and stroke, embolism, other than stroke, heart failure and other complications remain common [8]. The in-hospital mortality rate in our study was 10.9%, which is similar to the reports from the developed countries [8, 24], but lower than the reports from Spain [25] and India [12]. There was no significant difference in mortality between the two consecutive periods in our study.…”

Infective endocarditis: Surgical management and prognostic predictors

“…In agreement with recent studies, 1,7,8 there was a predominance of Staphylococcus spp. over Streptococcus spp., which used to be the most prevalent pathogen.…”

Bacteria endocarditis consolidation with vertebra bone tuberculosis: a case report

“…In recent decades, the epidemiological characteristics and the clinical features of BE has changed because of the widely use of broad-spectrum antibiotics and the increasing patients with cardiac surgery and heart intervention operation [9]. BE remains as a life threatening disease with high morbidity and mortality.…”