Current E-Cigarette Research in the Context of Asthma

Hickman, Elise; Jaspers, Ilona

doi:10.1007/s11882-020-00952-2

Cited by 23 publications

(11 citation statements)

References 86 publications

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“…Respiratory innate immune cell function has also been found to be impaired by flavored EC liquids and more specifically, by cinnamaldehyde which suppresses phagocytosis by macrophages [ 29 ], and provisionally represses ciliary mobility of bronchial epithelial cells through dysregulation of mitochondrial function [ 30 ]. These dysregulations of the respiratory immunity by EC could impact asthma development, severity, and/or exacerbations [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-nine observational studies including 2,111,023 participants, six case studies, two opinion articles, eight reviews, and five systematic reviews with four meta-analyses investigated the effects of EC use in asthmatics ( Table 2 ). Several investigators have concluded that EC could be associated with the development of pulmonary disorders, including asthma and might increase asthma severity and exacerbations [ 18 , 31 , 61 , 62 , 63 , 64 ]. Numerous cross-sectional studies with a large number of participants have described the significant association between EC use and even secondhand exposure and asthma diagnosis and severity [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ], compared to the few studies which found no association [ 75 , 76 ], or even negative association between EC use and asthma [ 77 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

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Electronic Cigarettes and Asthma: What Do We Know So Far?

Kotoulas

Κatsaounou

Riha

et al. 2021

JPM

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Electronic cigarettes (EC) are a novel product, marketed as an alternative to tobacco cigarette. Its effects on human health have not been investigated widely yet, especially in specific populations such as patients with asthma. With this review, we use the existing literature in order to answer four crucial questions concerning: (1) ECs’ role in the pathogenesis of asthma; (2) ECs’ effects on lung function and airway inflammation in patients with asthma; (3) ECs’ effects on asthma clinical characteristics in asthmatics who use it regularly; and (4) ECs’ effectiveness as a smoking cessation tool in these patients. Evidence suggests that many EC compounds might contribute to the pathogenesis of asthma. Lung function seems to deteriorate by the use of EC in this population, while airway inflammation alters, with the aggravation of T-helper-type-2 (Th2) inflammation being the most prominent but not the exclusive effect. EC also seems to worsen asthma symptoms and the rate and severity of exacerbations in asthmatics who are current vapers, whilst evidence suggests that its effectiveness as a smoking cessation tool might be limited. Asthmatic patients should avoid using EC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Electronic Cigarettes and Asthma: What Do We Know So Far?

Kotoulas

Κatsaounou

Riha

et al. 2021

JPM

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“…Several recent meta-analyses have drawn strong associations between e-cigarette use with the prevalence of asthma or COPD [46] , [47] . Moreover, in conditions such as asthma, where the respiratory immune system is already dysregulated, e-cigarette use may exacerbate the pathology [48] . The overlap of asthmatic symptoms and underlying mechanism that drive pathophysiology may resemble that of e-cigarette use, but more concrete and targeted studies need to be performed in human subjects to determine if and how e-cigarette may cause asthma and/or worsen symptoms in patients with existing respiratory diseases.…”

Section: The Health Impacts Of Vaping E-cigarettesmentioning

confidence: 99%

Health effects and known pathology associated with the use of E-cigarettes

et al. 2022

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“…Moreover, rodent models have revealed that nicotine exposure of dams causes lung developmental abnormalities in the offspring, and lead to transmission of asthma-like symptoms through multiple generations (Clapp and Jaspers, 2017) suggestive of epigenetic imprinting. As ECs can have a plethora of effects on the pulmonary system including the microbiome, detailed studies on the effect of EC on respiratory microbiome in asthmatics and non-asthmatics would be pertinent (Hickman and Jaspers, 2020).…”

Section: Smokingmentioning

confidence: 99%

Human matters in asthma: Considering the microbiome in pulmonary health

et al. 2022

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Graphical AbstractExogenous factors that influence the microbiome and asthma pathogenesis. External factors including a well-balanced diet and clean air support a healthy gut microbiome that releases metabolites and short-chain fatty acids (SCFA) that promote a healthy pulmonary immune system that remains non-inflammatory thereby protecting against the development of asthma or asthma exacerbations (left panel). An unhealthy diet, dirty air, and some pharmaceutical agents on the other hand can induce dysbiosis in the gut and lung microbial communities through induction of co-morbid states like obesity and aberrant immune activation. Additional confounders including modes of delivery and feeding, use of antibiotics during pregnancy and childhood also have an impact on the airway microbial homeostasis and asthma onset and pathogenesis (right panel). Figure prepared on BioRender.

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Current E-Cigarette Research in the Context of Asthma

Cited by 23 publications

References 86 publications

Electronic Cigarettes and Asthma: What Do We Know So Far?

Electronic Cigarettes and Asthma: What Do We Know So Far?

Health effects and known pathology associated with the use of E-cigarettes

Human matters in asthma: Considering the microbiome in pulmonary health

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