Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases

Воробьева, И. В.

doi:10.17116/oftalma20151315104-108

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Besides its role in fighting cancer, Bilberry is an effective support against type 2 Diabetes (12-15), vision improvement (16)(17)(18), obesity (19)(20)(21), cancer prevention (22)(23)(24), ulcerative colitis (25), anti-inflammatory (26,27), antioxidant (28,29), and gingival inflammation (30).…”

Section: Discussionmentioning

confidence: 99%

Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins

Thibado

Thornthwaite²,

Ballard³

et al. 2017

mol clin onc

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Abstract. Rapidly accumulating laboratory and clinical research evidence indicates that anthocyanins exhibit anticancer activity and the evaluation of bilberry anthocyanins as chemo-preventive agents is progressing. It has previously been demonstrated that anthocyanins upregulate tumor suppressor genes, induce apoptosis in cancer cells, repair and protect genomic DNA integrity, which is important in reducing age-associated oxidative stress, and improve neuronal and cognitive brain function. Bilberry anthocyanins have pronounced health effects, even though they have a low bioavailability. To increase the bioavailability, Bilberry was encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins]. These Bilberry NNS were used to study the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells. Flow cytometric fluorescent quantification of the uptake of propidium iodide in a special cell viability formulation into dead K562 cells was used to determine the effects of Bilberry on the viability of K562 cells. The concentrations of Bilberry that demonstrated the greatest levels of percentage inhibition, relative to the control populations, were biphasic, revealing a 60-70% inhibition between 0.018-1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml. The lowest percentage inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01-0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure. At 48 h incubation, the highest percentage of inhibition was only 27%, suggesting involvement of a long-term apoptotic event. These levels, which demonstrated direct cytotoxic effects, were 8-40 times lower than levels required for Bilberry that is not encapsulated. The increase in bioavailability with the Bilberry NNS and its water solubility demonstrated the feasibility of using Bilberry NNS in cancer patient clinical trials.

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Section: Discussionmentioning

confidence: 99%

Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins

Thibado

Thornthwaite²,

Ballard³

et al. 2017

mol clin onc

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“…Loshchilov, N.V. Marakhovskaya, etc.). Of particular interest in the context of developing the theoretical foundations of ECB creation and clearance in preparing social pedagogues for the prevention of social dependencies are the concept of ECBs (Tyunnikov, 2001;Chernenko, 2000) whereby ECBs are considered within a system of goal-functional, content, structural, temporal, and instrumental design characteristics and the central tenets of an integrated approach to preventing social dependencies in teenagers (Vorob'eva et al, 2012;Maznichenko, Neskoromnykh, 2013).…”

Section: Methodsmentioning

confidence: 99%

Educational-Cognitive Barriers in the Preparation of Future Social Pedagogues for the Prevention of Social Dependencies

2017

European Journal of Contemporary Education

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This paper brings to light the essence, characteristics, and role of educational-cognitive barriers in the preparation of college-attending future social pedagogues that may arise in the process of their mastering social-pedagogical skills related to the prevention of social dependencies. The authors share the findings of their study of a typology of such obstacles in the educational process. Special attention is devoted to typical educational situations in the preparation of students (e.g., getting engaged in methodological activity related to preventing social dependencies, testing mastered methodological schemes and algorithms in activity related to preventing social dependencies, and discovering methodological knowledge) and specific educational-cognitive barriers dominating these situations.

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“…Blueberries and bilberries can be used to develop nutritional supplements for the prevention of diabetic retinopathy. Bilberry anthocyanosides promote the synthesis and regeneration of rhodopsin, increase the sensitivity of the retina to changes in light intensity, improve the blood supply to the retina, visual acuity and dark adaptation [142]. Bilberry extract treatment also decreased the expression of DR markers, such as degradation of zonula occludens-1, occludin, claudin-5, and retinal VEGF, and prevented or delayed the onset of early diabetic retinopathy in diabetic rats [143].…”

Section: Treating Dr and Dkdmentioning

confidence: 98%

Vaccinium as Potential Therapy for Diabetes and Microvascular Complications

Luo

Wang

Zhang³

et al. 2023

Nutrients

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Diabetes mellitus is one of the most critical global health concerns, with a fast-growing prevalence. The incidence of diabetic vascular complications is also rapidly increasing, exacerbating the burden on individuals with diabetes and the consumption of public medical resources. Despite the overall improvements in the prevention, diagnosis, and treatment of diabetic microvascular complications in recent years, safe and effective alternative or adjunctive therapies are urgently needed. The mechanisms underlying diabetic vascular complications are complex, with hyperglycemia-induced oxidative stress and inflammation being the leading causes. Therefore, glycemic control, antioxidation, and anti-inflammation are considered the main targets for the treatment of diabetes and its vascular comorbidities. Vaccinium L. (Ericaceae) is a genus of plants enriched with polyphenolic compounds in their leaves and fruits. Vaccinium and its extracts have demonstrated good bioactivity in reducing blood glucose, oxidative stress, and inflammation, making them excellent candidates for the management of diabetes and diabetic vascular complications. Here, we review recent preclinical and clinical studies on the potential effect of Vaccinium on ameliorating diabetes and diabetic complications, particularly diabetic kidney disease and diabetic retinopathy.

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Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases

Cited by 8 publications

References 40 publications

Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins

Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins

Educational-Cognitive Barriers in the Preparation of Future Social Pedagogues for the Prevention of Social Dependencies

Vaccinium as Potential Therapy for Diabetes and Microvascular Complications

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