Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malignant transformation

Lodi, Giovanni; Scully, Crispian; Carrozzo, Marco; Griffiths, Mark; Sugerman, Philip B.; Thongprasom, Kobkan

doi:10.1016/j.tripleo.2004.06.076

Cited by 379 publications

(414 citation statements)

References 172 publications

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“…7-8-,10,12-15 Furthermore, other conditions may also present similar histopathological findings as those found in OLP, including lichenoid reactions, lupus erythematosus, leukoplasia, erythroleukoplasia, and proliferative verrucous leukoplasia. 10 Our results, however, suggest that atypical mitoses and abnormal cell differentiation are inherent to the epidermoid carcinoma, and that hyperchromatic nuclei and cell pleomorphism are seen more often in this disease, rather than in OLP. Thus, such changes might help separate OLP from other dysplastic diseases, which are potentially precancerous.…”

Section: Discussioncontrasting

confidence: 63%

“…This is probably because some of the inflammatory features are similar to those seen in malignancies, particularly those that indicate increased proliferation due to the many growth factors released to epithelial cells in chronic inflammation. 10 Mignogna et al 11 (2004) have suggested that such alterations should be analyzed with greater care, since there is current evidence showing that chronic inflammation may create a cytokine-based microenvironment capable of affecting cell lifetime, growth, proliferation and differentiation, which may lead to cancer promotion and progression.…”

Section: Discussionmentioning

confidence: 99%

“…This is probably because the inflammation present in OLP may cause cell alterations similar to those seen in epithelial dysplasia or in epidermoid carcinoma. 10 In this context, the purpose of this study was to analyze the changes in epithelial cells of OLP, and to compare such changes with those found in the epidermoid carcinoma; the intention was to seek for similarities and differences to facilitate the histopathological diagnosis and establish its inflammatory nature.…”

Section: Introductionmentioning

confidence: 99%

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Estudo comparativo das alterações celulares no líquen plano e no carcinoma epidermóide bucal

Sousa¹,

Paradella²,

Brandão

et al. 2009

Rev. Bras. Otorrinolaringol.

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Atualmente, muito se discute a respeito da natureza pré-maligna do líquen plano bucal. OBJETIVO: O presente trabalho tem como objetivo analisar as alterações das células epiteliais presentes no líquen plano bucal, comparando-as com aquelas observadas no carcinoma epidermóide. MATERIAL E MÉTODO: Cortes histológicos de líquen plano bucal e carcinoma epidermóide, corados com hematoxilina-eosina, foram analisados por meio da microscopia de luz. RESULTADO: As alterações mais frequentemente observadas no líquen plano bucal foram aumento da relação núcleo/citoplasma (93,33%), espessamento da membrana nuclear (86,67%) e bi-ou multinucleação (86,67%). O teste t de Student (alfa=5%) revelou haver diferença estatisticamente significante entre o número médio de alterações celulares no líquen plano bucal (5,87±1,57) e no carcinoma epidermóide (7,60±1,81). Quanto aos tipos de alterações, o teste de qui-quadrado também revelou haver diferença estatisticamente significante entre as lesões avaliadas em relação às seguintes alterações celulares: hipercromatismo nuclear, mitoses atípicas, pleomorfismo celular e diferenciação celular anormal (p<0,05). CONCLUSÃO: Apesar de que, em alguns casos, alguns patologistas possam fazer confusão no diagnóstico histopatológico do líquen plano bucal, os resultados obtidos neste estudo mostram que as alterações presentes no líquen plano bucal diferem consideravelmente daquelas observadas no carcinoma epidermóide, evidenciando o quão distintas são estas duas doenças.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Estudo comparativo das alterações celulares no líquen plano e no carcinoma epidermóide bucal

Sousa¹,

Paradella²,

Brandão

et al. 2009

Rev. Bras. Otorrinolaringol.

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“…Although there is controversy as to the potentially malignant nature of these conditions (Lodi et al, 2005;Van der Meij et al, 2007), it is generally accepted that lichen planus/lichenoid lesions can be OPMDs (Warnakulasuriya et al et al, 2007;Van der Waal, 2014). The exact mechanism that drives lichen planus/lichenoid lesions to cancer is not known, but it is believed that the chronic inflammatory microenvironment in lichen planus might cause crucial DNA damage which over time results in cancer development (Georgakopoulou et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Hassona¹,

Scully²,

Almangush³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To determine the prevalence, types, and risk factors of oral potentially malignant disorders (OPMDs) among a group of Arab Jordanian dental patients, and to evaluate their awareness and attitudes toward early diagnosis and treatment. Materials and Methods: A total of 1,041 patients attending a University Hospital for dental care were examined for the presence of OPMDs. Histopathological examination was performed on all cases clinically diagnosed and patients were directly interviewed to evaluate their knowledge and attitudes toward early detection and treatment of oral cancer. Results: The prevalence of OPMDs overall was 2.8%. Lichen planus/lichenoid lesions were the most common lesions (1.8%) followed by leukoplakias (0.48%), chronic hyperplastic candidiosis (0.38%), and erythroplakia (0.096%). Smoking, alcohol, and age (>40 years) were the main identifiable risk factors. Patients with OPMDs displayed a general lack of awareness and negative attitudes towards early diagnosis and treatment. Conclusions: OPMDs among Arab dental patients are relatively uncommon and awareness about oral cancer among Jordanian dental patients is low. Interventions to improve public knowledge about oral cancer and attitudes toward early diagnosis and treatment are urgently indicated.

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“…Diagnosis of LDR lesions can only be made by verifying that remission occurs upon withdrawal of medication coupled with recurrence on re-challenge. In cases of LDRs where the regime of medication cannot be substituted, reduced or withdrawn, symptomatic patients can be treated with topical medication, mostly by application of corticosteroids (19,20).…”

Section: E756mentioning

confidence: 99%

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Hirota

Moreno²,

Santos³

et al. 2011

Med Oral

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Objectives: To investigate whether daily systemic and/or topical medication contributes to the development of oral lichen planus (OLP) lesions. Study Design: The study involved 110 OLP patients and 76 control subjects, matched by age, race and sex. The analyzed data included medical records, drug intake and topical medication. Criteria for analysis of drug intake included: (1) ATC-code drug classification; (2) number of different drugs used daily in the categories of monopharmacy (1 drug), minor polypharmacy (2-4 drugs), and major polypharmacy (> 5 drugs); and (3) drugs implicated in lichenoid reactions (DILRs). Results: Sixty (54.5%) of the 110 OLP patients reported daily medication (prior to the appearance of the OLP lesion) compared to 52 (68.4%) of the 76 control subjects. No statistical difference was found between the two groups in terms of systemic diseases, number of medicated individuals in the categories of mono-and polypharmacy, nor use of DILRs (P > 0.05). Regarding the clinical forms and site of involvement, a statistically significant difference was only found for the clinical erosive form of OLP, seen more frequently in non-DILR (P = 0.04) and nonmedicated OLP patients (P = 0.02) than in DILR OLP patients. Daily use of topical oral medication was reported by 2 (1.8%) OLP patients and 1 (1.3%) control subject. Conclusions: It seems that the use of systemic medication does not lead to a significant increase in the incidence of OLP lesions. For their part, lichenoid drug reactions are likely to occur only in a very low percentage of patients.

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Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malignant transformation

Cited by 379 publications

References 172 publications

Estudo comparativo das alterações celulares no líquen plano e no carcinoma epidermóide bucal

Estudo comparativo das alterações celulares no líquen plano e no carcinoma epidermóide bucal

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

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