Current concepts in the treatment of anovulation.

Rabau, E; Serr, David M.; Mashiach, Shlomo; Insler, V.; Salomy, M; Lunenfeld, Bruno

doi:10.1136/bmj.4.5577.446

Cited by 39 publications

(5 citation statements)

References 11 publications

(12 reference statements)

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“…Multiple pregnancy is a known complication following induction of ovulation. Incidences of twins of 9.4% and 12.8% have been reported following induction of ovulation with clomiphene citrate (3.10) and may be as high as 40% when gonadotrophin therapy is used (11). Our vindings are in agreement with those figures.…”

Section: Discussionsupporting

confidence: 90%

Pregnancy Outcome after Female Infertility in Kuwait: Comparison of Medical and Surgical Treatment

El-ashnehi

Ibrahim²,

El-Tamamy³

et al. 1990

Acta Obstet Gynecol Scand

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During a 4-year period, 163 patients conceived after treatment of their infertility due solely to a female factor. They were divided into two groups, 108 patients treated medically (Group 1) and 55 treated surgically (Group 2). At the time of conception, the mean age in Group (1) was 24.9 +/- 5.7 years while in Group (2) it was 31.2 +/- 6.1 years. The difference was statistically significant (p less than 0.01). The duration of infertility prior to pregnancy and the treatment-to-pregnancy interval were both significantly longer in Group (2) (p less than 0.05). The rates of miscarriage, multiple pregnancy, and preterm labor were higher in Group (1), though the differences were statistically not significant. In contrast, the rate of ectopic pregnancy was significantly higher in Group (2) (p less than 0.05), as was the need for elective cesarean section (p less than 0.01). Despite these differences, both groups had nearly the same perinatal outcome.

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Section: Discussionsupporting

confidence: 90%

Pregnancy Outcome after Female Infertility in Kuwait: Comparison of Medical and Surgical Treatment

El-ashnehi

Ibrahim²,

El-Tamamy³

et al. 1990

Acta Obstet Gynecol Scand

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“…However, CC has a long half-life that may have a negative effect on the cervical mucus and endometrium. In addition, CC treatment is associated with a discrepancy between ovulation and conception rates, and the incidence of miscarriage is higher than in the general population (2)(3)(4)(5). Gonadotropin is an alternative drug for superovulation.…”

mentioning

confidence: 99%

A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation

Al-Fozan

Al-Khadouri

Tan

et al. 2004

Fertility and Sterility

158

107

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“…These phenomena have been attributed to the antiestrogenic effects of CC [1,10,14,16,17,21,27], A commonly suggested treatment has been the addition of exogenous estrogen to counteract these effects, particu larly the effect on cervical mucus [20,21], However, the available data on EE therapy for CC-suppressed cervical mucus quantity and quality is in doubt, despite markedly increased serum estradiol levels [4,10].…”

Section: Discussionmentioning

confidence: 99%

Exogenous Estrogen Therapy Concurrent with Clomiphene Citrate-Lack of Effect on Serum Sex Hormone Levels and Endometrial Thickness

Ben‐Ami

Geslevich²,

Matilsky³

et al. 1994

Gynecol Obstet Invest

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The antiestrogenic action of clomiphene citrate (CC) is claimed to have an adverse effect on the development of the secretory endometrium. This effect can be assessed: (1) sonographically by measuring endometrial thickness, and (2) by serum hormone levels. The aim of this study was to evaluate whether administering ethinyl estradiol (EE) during CC treatment has any effect on endometrial thickness and/or hormone levels. Seventeen patients were treated with CC for one cycle and with CC plus EE in an adjacent cycle either before or after. The patients were followed by daily assessment of endometrial thickness, follicular growth and serum estradiol levels as well as midluteal prolactin and progesterone levels. We did not find any significant difference in either endometrial thickness, estradiol level, midluteal prolactin or progesterone levels between the two treatment protocols. We conclude that exogenous EE, in the dosage used in this study, does not overcome CC-induced alterations in endometrial thickness.

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Current concepts in the treatment of anovulation.

Cited by 39 publications

References 11 publications

Pregnancy Outcome after Female Infertility in Kuwait: Comparison of Medical and Surgical Treatment

Pregnancy Outcome after Female Infertility in Kuwait: Comparison of Medical and Surgical Treatment

A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation

Exogenous Estrogen Therapy Concurrent with Clomiphene Citrate-Lack of Effect on Serum Sex Hormone Levels and Endometrial Thickness

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