A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation

Al-Fozan, Haya; Al-Khadouri, Maha; Tan, Seang Lin; Tulandi, Togas

doi:10.1016/j.fertnstert.2004.04.070

Cited by 158 publications

(126 citation statements)

References 20 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…This is in good agreement with recent reports which conclude that letrozole has a better ovulation and pregnancy rate as compared to CC in patients with PCOS [22,23]. Several smaller prospective randomized trials have also shown that letrozole may be an acceptable alternative to CC as an ovulation induction drug in women with PCOS [24][25][26]. An ovulation rate of 54.6% and pregnancy rate of 25% with letrozole induction in CC-resistant women with PCOS is reported [2].…”

Section: Discussionsupporting

confidence: 90%

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Ganesh

Goswami

Chattopadhyay

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Letrozole, though reported to be an effective ovulation inducing agent, warrants larger randomized trials. The purpose of this study is to compare the efficacy of letrozole with that of rFSH and clomiphene citrate(CC)/rFSH for ovarian stimulation in IUI cycles. Methods Randomized, prospective, single-blinded clinical trial. 1387 PCOS women after CC failure were randomized into three groups: Group A received letrozole, Group B received CC with two doses rFSH and Group C received continuous rFSH day 2 onwards until hCG injection. Results Group A, B and C had an ovulation rate of 79.30%, 56.95% and 89.89% and cycle cancellation rate of 20.70%, 43.05% and 10.11%, respectively. Pregnancy rates in Group A, B and C were 23.39%, 14.35% and 17.92%, while the miscarriage rates were 13.80%, 16.67% and 14.52%, respectively. Conclusion Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and is found to be most effective when baseline estradiol level >60 pg/ml.

show abstract

Section: Discussionsupporting

confidence: 90%

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Ganesh

Goswami

Chattopadhyay

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…This finding is not in agreement with Al-Fouzan et al who reported higher number of mature follicles in the letrozole group than in the CC group. 17 Endometrial thickness was significantly higher in letrozole group in the current study. Similar findings were reported by Mitwally and Casper.…”

Section: Mitwally and Caspersupporting

confidence: 41%

“…3,4 Letrozole; an aromatase inhibitor, has been tried by many researchers as an alternative treatment to CC in different regimens. [12][13][14][15][16][17][18] The optimal dose of letrozole for ovulation induction in patients with PCOS has not been yet determined. Most of the published studies had used letrozole in a fixed dose (2.5-7.5 mg) starting from cycle day 2 to 6.…”

Section: Resultsmentioning

confidence: 99%

Optimized Letrozole Dose Versus Traditional Use of Clomiphene Citrate for Ovulation Induction in Patients With PCOS: A Prospective Randomized Controlled Trial

Elkhateeb¹,

Mahran²

2016

Gynecol Obstet Res Open J

View full text Add to dashboard Cite

Citation : patients were randomly allocated into two groups; study group (100 patients) receiving gradually increased doses of letrozole starting with 2.5 mg on cycle day 3 with incremental increase of 2.5 mg daily till reaching a dose of 10 mg daily on cycle day 6 and a control group (100 patients) receiving CC at a dose of 100 mg daily for 5 days starting from cycle day 3. Patients were followed up for three treatment cycles. The primary outcome was clinical pregnancy rate and the secondary outcome was number of mature follicles, endometrial thickness, serum progesterone and time to reach a dominant follicle. Result(s):The two groups were similar in the demographic features and baseline hormonal milieu. There was no significant difference between the two groups as regards the number of mature follicles and the time to reach mature follicles. Endometrial thickness on HCG day was significantly higher in the letrozole group as compared with CC group (10.1±0.22 mm vs 8.2±0.69 mm, p=0.01)). Serum progesterone was higher in letrozole group than in CC group (19.3±3.1 vs 15.3±2.2, p<0.01). Ovulation was achieved in165/242 cycles (68.2 %) in the letrozole group and 169/249 cycles (67.9 %) in the CC group which was not statistically significant. Clinical pregnancy rate was significantly higher in letrozole group in comparison with CC group (14.8 % vs 10.4 %, p<0.01) Conclusion(s): Letrozole in gradually increased dose achieves higher clinical pregnancy rate as compared with the traditional dose of CC. Therefore, it can be used as a first-line treatment for ovulation induction in women with PCOS.

show abstract

“…Dosing is started low, usually at 2.5 mg to ensure response can be monitored and avoid cycle cancellation if an exaggerated follicular response is seen. Higher doses are associated with poorer endometrial thickness, but not at the levels seen with clomiphene citrate [35].…”

Section: Letrozolementioning

confidence: 77%

Fertility Treatment for Women with PCOS

Langdon¹,

Pontré²,

Hart³

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

View full text Add to dashboard Cite

Polycystic ovarian syndrome is the commonest cause of anovulatory infertility. This chapter will explore fertility treatment options for this condition including the risks, benefits and success rates for different treatment methods. The importance of close patient monitoring with hormone levels and pelvic ultrasounds to ensure mono-ovulation and to avoid ovarian hyperstimulation syndrome will be highlighted.

show abstract

A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation

Cited by 158 publications

References 20 publications

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Optimized Letrozole Dose Versus Traditional Use of Clomiphene Citrate for Ovulation Induction in Patients With PCOS: A Prospective Randomized Controlled Trial

Fertility Treatment for Women with PCOS

Contact Info

Product

Resources

About