Current Concepts in the Management of Periodontitis

Kwon, TaeHyun; Lamster, Ira B.; Levin, Liran

doi:10.1111/idj.12630

Cited by 415 publications

(329 citation statements)

References 135 publications

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“…Dental plaque is a dynamic entity made up of salivary proteins, minerals and, mainly, bacteria, which mutually benefit from the coaggregation, adhesion and metabolic interactions [43] and arrange in a biofilm on the hard and soft tissue of the mouth. The polymicrobial biofilm, which composes dental plaque changes over time and maturates according to diet, oral hygiene habits and location.…”

Section: Composition Of Supragingival and Subgingival Plaquementioning

confidence: 99%

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Contaldo

Lucchese

Romano

et al. 2021

IJMS

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Down syndrome (DS) is a genetic disorder associated with early-onset periodontitis and other periodontal diseases (PDs). The present work aimed to systematically review the scientific literature reporting studies in vivo on oral microbiota features in subjects with DS and related periodontal health and to highlight any correlation and difference with subjects not affected by DS, with and without PDs. PubMed, Web of Science, Scopus and Cochrane were searched for relevant studies in May 2021. The participants were subjects affected by Down syndrome (DS) with and without periodontal diseases; the study compared subjects with periodontal diseases but not affected by DS, and DS without periodontal diseases; the outcomes were the differences in oral microbiota/periodontopathogen bacterial composition among subjects considered; the study design was a systematic review. Study quality was assessed with risk of bias in non-randomized studies of interventions (ROBINS-I). Of the 954 references retrieved, 26 studies were considered. The conclusions from the qualitative assessment of the papers revealed an increasing knowledge over the last years of the microbiota associated with DS and their periodontal diseases, in comparison with healthy subjects and subjects with other kinds of mental disabilities. Few data have emerged on the mycobiome and virobiome of DS, hence, further investigations are still necessary.

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Section: Composition Of Supragingival and Subgingival Plaquementioning

confidence: 99%

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Contaldo

Lucchese

Romano

et al. 2021

IJMS

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“…Dental plaque changes over time and depending on the location, so that early and mature plaques, supragingival and subgingival plaques, differ greatly from each other and are responsible for various and different pathologies, the most prevalent of which are caries and periodontal diseases. This is due to the fact that, by definition, dental plaque is a polymicrobial biofilm made up of various bacterial complexes, which mutually benefit from coaggregation, adhesion, and metabolic interactions [15].…”

Section: Dental Plaque Characterizationmentioning

confidence: 99%

The Oral Microbiota Changes in Orthodontic Patients and Effects on Oral Health: An Overview

Contaldo

Lucchese

Lajolo

et al. 2021

JCM

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Nowadays, there is a considerable interest to study the biological and microbiological changes that accompany orthodontic treatment. Growing knowledge on oral microbiota allows, day after day, to identify and characterize the microbial arrangements specifically associated with oral and extra-oral conditions. The aim of the present work is to highlight any further correlations between orthodontic appliances and the qualitative and quantitative modifications of the oral microbiota, such as predisposing factors for the onset of caries, periodontal diseases, and other infections, which can impact the oral and systemic health of the orthodontic patients. When compared with subjects without orthodontic appliances, orthodontic patients reported significant qualitative and quantitative differences in supra- and subgingival plaque during the entire treatment period. Certain components of fixed appliances (mainly bonded molar brackets, ceramic brackets, and elastomeric ligatures) showed high risks of periodontal disease and tooth decay for patients. An unclear prevalence of Candida spp. and the paucity of studies on viruses and protozoas in the oral microbiota of orthodontic patients need to be further investigated. The evidence emerging from this study could guide clinicians in modulating the timing of controls and enhance patient motivation to prevent the formation of mature plaque, thus reducing the risks of oral-plaque-related diseases.

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“… 51 52 In particular, a group of specific gram-negative anerobic species known as the “red complex” results in chronic inflammation. 53 The subgingival plaque biofilm causes inflammation and elicits immune responses of the host, leading to irreversible destruction of the periodontal tissues eventually, especially alveolar bone and PDL of the susceptible host. 51 54 55 …”

Section: The Relationship Between Plaque Microorganism and Alveolar Bone Lossmentioning

confidence: 99%

Effects of DSPP Gene Mutations on Periodontal Tissues

Jing

Chen

Jiang

2021

Global Medical Genetics

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Dentin sialophosphoprotein (DSPP) gene mutations cause autosomal dominantly inherited diseases. DSPP gene mutations lead to abnormal expression of DSPP, resulting in a series of histological, morphological, and clinical abnormalities. A large number of previous studies demonstrated that DSPP is a dentinal-specific protein, and DSPP gene mutations lead to dentin dysplasia and dentinogenesis imperfecta. Recent studies have found that DSPP is also expressed in bone, periodontal tissues, and salivary glands. DSPP is involved in the formation of the periodontium as well as tooth structures. DSPP deficient mice present furcation involvement, cementum, and alveolar bone defect. We speculate that similar periodontal damage may occur in patients with DSPP mutations. This article reviews the effects of DSPP gene mutations on periodontal status. However, almost all of the research is about animal study, there is no evidence that DSPP mutations cause periodontium defects in patients yet. We need to conduct systematic clinical studies on DSPP mutation families in the future to elucidate the effect of DSPP gene on human periodontium.

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Current Concepts in the Management of Periodontitis

Cited by 415 publications

References 135 publications

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

The Oral Microbiota Changes in Orthodontic Patients and Effects on Oral Health: An Overview

Effects of DSPP Gene Mutations on Periodontal Tissues

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