Current Concepts in Psoriatic Arthritis

Abstract

Psoriatic arthritis is an inflammatory arthropathy associated with psoriasis and characterized by absence of rheumatoid factor. Any form of psoriasis can be complicated by joint inflammation. Four groups have been identified: pauciarticular psoriatic arthritis, psoriatic spondylitis, symmetrical polyarticular psoriatic arthritis and arthritis mutilans. The etiology of psoriatic arthritis remains unclear. Genetic, immunologic and environmental factors are thought to be important in the development of the disease. The role of cytokines and adhesion molecules in the mechanism of joint destruction is highlighted, and recent therapeutic strategies are discussed.

Diversity of OspA and OspC among cerebrospinal fluid isolates of Borrelia burgdorferi sensu lato from patients with neuroborreliosis in Germany

“…Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy occurring in some 5±40% of patients with psoriatic skin disease [20,28]. The pathogenesis of psoriasis vulgaris and PsA is a multifactorial process involving genetic, immunological and environmental factors [1,7].…”

“…Both humoral and cellular immunological factors are assumed to play a role in the pathogenesis of PsA. The cellular involvement is supported by the ®nding of a signi®cant in®ltration of the PsA synovial membrane by lymphocytes and macrophages [27,28]. The in®ltrating lymphocytes show signs of activation such as the expression of HLA-DR molecules and IL-2 receptors [9].…”

Psoriatic arthritis associated with chondrolysis and osteolysis

“…autoimmune haemolytic anaemia, autoimmune thrombopenia and Hashimoto's autoimmune thyroiditis, following allogeneic BMT are also reported [4,5]. So far there has only been reported one patient who acquired PA soon after BMT from a donor suffering from PA [6 ]. We report on another patient, who developed PA following allogeneic BMT from his HLA-identical brother suffering from psoriasis.…”

“…In the patellofemoral joint. Cartilage and bone marrow addition, fibroblast proliferation and inflammatory cytospecimens (diameter~5 mm) were obtained from the kines are responsible for rupture of the joint capsule, anterior non-weight-bearing area of the medial condyle giving rise to clinical joint deformities [6 ]. of the femur by inserting a trocar toward the lesion in…”

Erste Ergebnisse der Therapie der Psoriasisarthritis mit Mycophenolatmofetil

“…Therapiemöglichkeiten(6,10,32). Jones et al berichteten über therapeutische Optionen der Psoriasisarthritis als Ergebnis einer Metaanalyse von 12 randomisierten Untersuchungen.…”