Current Concepts in Cell Death

Abstract

This unit attempts to define cell toxicity that leads to cellular demise, with a strong emphasis on cell death via both apoptosis and necrosis, by summarizing some of the more recent developments in cellular, molecular, and biochemical studies of the events that govern the induction and execution of cell death. Specific topics pertaining to cell death include structural changes, macromolecular degradation, cellular signaling, the role of mitochondria, and genetic modulation of apoptotic cell death.

Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via FcγRI on phagocytes

“…6 Similarly, generation of primary necrotic cells by extreme trauma can also result in the permeabilization of the cell membrane. 7 The loss of membrane integrity exposes intracellular contents, which may function as additional "eat-me" signals to aid the removal of necrotic cells. 8 Most importantly, unlike the recognition of pathogens, apoptotic cell removal is generally considered as nonimmunogenic and induces an antiinflammatory response if the appropriate clearance mechanisms are present.…”

Modern Technologies and Approaches to Apoptosis Studies in Experimental Biology

“…У большинства эукариот в развитии апоптоза традиционно выделяют три стадии: сигнальную или индукционную, эффекторную и терминальную или деградационную. Среди морфологических изменений, имеющих место в апоптотозирующей клетке, большинство исследователей выделяет следующие [66, 72,73]:…”