Current Clinical Spectrum of Neurosyphilis in Immunocompetent Patients

Abstract

Background: Neurosyphilis (NS) is nowadays a less frequent disease. Its incidence and clinical spectrum have changed over time. Objective: To estimate the incidence of NS and describe the clinical spectrum of NS in immunocompetent patients in the last decade. Methods: Demographic and clinical features, cerebrospinal fluid (CSF) changes, neuroimaging findings and outcome were retrospectively analyzed. Results: Forty-three patients met NS criteria. The yearly incidence was 0.2– 2.1 cases per 100,000 inhabitants. The mean age was 48.1 years, males being more frequently involved. The most frequent clinical patterns were meningovascular (30.2%), meningeal (25.6%) and general paresis (25.6%). Compared to prepenicillin series, we observed a decrease in late forms, mainly tabes dorsalis. CSF titers studied by the Venereal Disease Research Laboratory were higher in early NS. Neuroimaging findings were nonspecific. Outcome was better for early forms. Conclusions: Compared to the preantibiotic era, a lower frequency of late NS was observed, similar to that reported in other modern series which include patients with HIV infection. Therefore, this trend seems to be due to the impact of antibiotics rather than to HIV infection.

Clinical and Laboratory Characteristics, Neuroimaging Alternations and Treatment Response of 25 HIV-Negative General Paresis Patients

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Clinical and Laboratory Characteristics, Neuroimaging Alternations and Treatment Response of 25 HIV-Negative General Paresis Patients

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Changes in neurosyphilis presentation: a survey on 286 patients

“…Meningeal involvement was present in 22% of our cases, a value comparable to the 25% found in a study conducted between 1991 and 2001 …”

Neurosyphilis with sequential respiratory complications: A case report highlighting diagnostic and treatment challenges

“…Cognitive impairment, behavioral abnormalities, dementia, depression, mania, and psychosis with auditory or visual hallucinations were other common signs. Similar results were revealed by an older study done by Conde-Sendín et al 12 A study by Lee et al 13 also found a similar presentation in 24 syphilitic patients. All of these symptoms, however, were not present in our case.…”

Clinical and Laboratory Characteristics, Neuroimaging Alternations and Treatment Response of 25 HIV-Negative General Paresis Patients

“……”

Changes in neurosyphilis presentation: a survey on 286 patients

“…Meningeal involvement was present in 22% of our cases, a value comparable to the 25% found in a study conducted between 1991 and 2001 …”

Neurosyphilis with sequential respiratory complications: A case report highlighting diagnostic and treatment challenges

“…Cognitive impairment, behavioral abnormalities, dementia, depression, mania, and psychosis with auditory or visual hallucinations were other common signs. Similar results were revealed by an older study done by Conde-Sendín et al 12 A study by Lee et al 13 also found a similar presentation in 24 syphilitic patients. All of these symptoms, however, were not present in our case.…”

Clinical and Laboratory Characteristics, Neuroimaging Alternations and Treatment Response of 25 HIV-Negative General Paresis Patients

“……”

Changes in neurosyphilis presentation: a survey on 286 patients

“…Meningeal involvement was present in 22% of our cases, a value comparable to the 25% found in a study conducted between 1991 and 2001 …”

Neurosyphilis with sequential respiratory complications: A case report highlighting diagnostic and treatment challenges

“…Cognitive impairment, behavioral abnormalities, dementia, depression, mania, and psychosis with auditory or visual hallucinations were other common signs. Similar results were revealed by an older study done by Conde-Sendín et al 12 A study by Lee et al 13 also found a similar presentation in 24 syphilitic patients. All of these symptoms, however, were not present in our case.…”