Current Challenges and Solutions in Research and Clinical Care of Older Persons Living with HIV: Findings Presented at the 9th International Workshop on HIV and Aging

Sundermann, Erin E.; Erlandson, Kristine M.; Pope, Caitlin N.; Rubtsova, Anna; Montoya, Jessica L.; Moore, Alison; Marzolini, Catia; O’Brien, Kelly K; Pahwa, Savita; Payne, Brendan; Rubin, Leah H.; Walmsley, Sharon; Haughey, Norman J.; Montano, Monty; Karris, Maile Y.; Margolick, Joseph B.; Moore, David J.

doi:10.1089/aid.2019.0100

Cited by 13 publications

(8 citation statements)

References 129 publications

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“…For example, interventional studies that utilize exercise in middle-aged and older PWH show benefits for physical components of frailty, and indirect effects on fatigue [43,44]. As HIV clinics begin to adopt new care models that include geriatric principles, our findings suggest that approaches incorporating prevention and treatment of neuropsychiatric conditions, renal disease, and diabetes have significant potential to delay or ameliorate frailty in aging PWH, and may provide better understanding of frailty phenotypes amenable to multimodal interventions [18,45].…”

Section: Discussionmentioning

confidence: 89%

Multimorbidity networks associated with frailty among middle-aged and older people with HIV

Lorenz

Mukerji

Misra

et al. 2021

Aids

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Objective: People with HIV (PWH) have increased prevalence of multimorbidity and frailty at younger ages compared with the general population. This study investigated individual and combinatorial effects of neuropsychiatric and medical comorbidities as predictors of frailty in PWH.Design: Analysis of data from the National NeuroAIDS Tissue Consortium, a longitudinal observational cohort.Methods: Five hundred and twenty-four PWH over age 40 years were classified using Fried's Frailty criteria. Twelve comorbidities were documented from longitudinal data and associations between individual and co-occurring comorbidities with frailty were assessed using weighted network and logistic regression analyses.Results: At frailty assessment between 2015 and 2020, median age was 61 years, 76% were men, 94% were on antiretroviral therapy (ART), 73% had two or more comorbidities, 24% were frail, and 52% were prefrail. Among individual comorbidities, highest odds of frailty were in participants with depressive symptoms [adjusted odds ratio (aOR), 95% confidence interval (CI) 3.48 (2.22-5.46)], followed by bone disease and chronic obstructive pulmonary disease (COPD) [2.47 (1.28-4.72) and 2.13 (1.36-3.34), respectively]. Among co-occurring comorbidities, highest odds of frailty were in participants having depressive symptoms with diabetes, hypertension, or obesity [aORs (

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Section: Discussionmentioning

confidence: 89%

Multimorbidity networks associated with frailty among middle-aged and older people with HIV

Lorenz

Mukerji

Misra

et al. 2021

Aids

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“…In the United States, 1.2 million people are living with HIV. Of these, more than 50% are 50 + years of age, and many physical complications related to long-term ART use and aging have arisen [18][19][20][21]. Older PLWH, in particular, have a higher risk of non-communicable comorbidities, including diabetes, hypertension, cardiovascular disease, and chronic lung disease than uninfected individuals of similar age [22][23][24][25].…”

Section: Comorbidities and Covid-19 In People Living With Hivmentioning

confidence: 99%

The Burden of COVID-19 in People Living with HIV: A Syndemic Perspective

et al. 2020

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The emergence of the novel coronavirus disease known as COVID-19 creates another health burden for people living with HIV (PLWH) who face multiple morbidities and may be at heightened risk for severe physical health illness from COVID-19. Our abilities to address these morbidities in PLWH must be considered alongside the socially-produced burdens that both place this population at risk for COVID-19 and heighten the likelihood of adverse outcomes. These burdens can affect the physical, emotional, and social well-being of PLWH and interfere with the delivery of effective healthcare and access to HIV treatment. We posit that a syndemic framework can be used to conceptualize the potential impact of COVID-19 among PLWH to inform the development of health programming services.

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“…Medical advancements such as combination antiretroviral therapy 10 have become more widespread, resulting in decreased mortality, increased life expectancy and thus, an increase in the numbers of older PWH in the United States. Older PWH may be especially vulnerable to age-associated social network changes, which can decrease adaptive coping and increase their risk of depressive symptoms, 11 especially for heterosexual PWH or those of color.…”

Section: Objectivementioning

confidence: 99%

Increased Social Interactions Reduce the Association Between Constricted Life-Space and Lower Daily Happiness in Older Adults With and Without HIV: A GPS and Ecological Momentary Assessment Study

Kamalyan

Yang

Pope

et al. 2021

The American Journal of Geriatric Psychiatry

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Current Challenges and Solutions in Research and Clinical Care of Older Persons Living with HIV: Findings Presented at the 9th International Workshop on HIV and Aging

Cited by 13 publications

References 129 publications

Multimorbidity networks associated with frailty among middle-aged and older people with HIV

Multimorbidity networks associated with frailty among middle-aged and older people with HIV

The Burden of COVID-19 in People Living with HIV: A Syndemic Perspective

Increased Social Interactions Reduce the Association Between Constricted Life-Space and Lower Daily Happiness in Older Adults With and Without HIV: A GPS and Ecological Momentary Assessment Study

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