Current challenges and future applications of antibacterial nanomaterials and chitosan hydrogel in burn wound healing

Bai, Que; Zheng, Caiyun; Chen, Wenting; Sun, Na; Gao, Qian; Liu, Jinxi; Hu, Fangfang; Sahu, Pimpi; Yan, Xintao; Zhang, Yanni; Lu, Tingli

doi:10.1039/d2ma00695b

Cited by 19 publications

(13 citation statements)

References 210 publications

(324 reference statements)

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“…It also demonstrated superior healing of bacterial-infected burn wounds compared to commercial products (Huang et al., 2022 ). However, the extensive use of antibiotics has led to the development of drug resistance in bacteria (Zhong et al., 2020 ; Bai et al., 2022 ). Therefore, in the past decade, antibiotic substitutes such as metal ions and naturally derived agents have emerged as leading candidates in the fight against wound infections (Zhong et al., 2020 ).…”

Section: Hydrogels As Transdermal Drug Delivery Carriers For Burn Wou...mentioning

confidence: 99%

“…In addition to the previously mentioned antimicrobial agents, antimicrobial peptides (AMPs) offer an alternative to antibiotics in fighting drug-resistant bacteria while being less prone to drug resistance (Bai et al., 2022 ). These peptides have been successfully incorporated into hydrogels for burn wound treatment (Ouyang et al., 2018 ; Zhou et al., 2023 ), enabling sustained and controlled release to maintain their bioactivity.…”

Section: Hydrogels As Transdermal Drug Delivery Carriers For Burn Wou...mentioning

confidence: 99%

“…The incorporation of silver NPs (AgNPs) into hydrogel overcomes the safety and efficacy issues associated with silver ions-incorporating hydrogel. By incorporating AgNPs, the hydrogel can achieve prolonged and controlled release of AgNPs into the wound tissue (Bai et al., 2022 ). Additionally, due to their small size, AgNPs have better penetration capability in deeper wounds compared to silver ions.…”

Section: Strategies To Enhance Transdermal Drug Delivery For Burn Wou...mentioning

confidence: 99%

“…Both third and fourth-degree burns require surgical intervention. In summary, the severity of burns increases with the degree of the burn (Bai et al., 2022 ). Consequently, the duration of wound healing and the care required for burn wounds are heavily dependent on the severity of the burns (Tiwari, 2012 ; Jeschke et al., 2020 ; Bai et al., 2022 ) ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Goh,

Du,

Peng

et al. 2024

Drug Delivery

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Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydrogel facilitates the penetration of loaded therapeutic agents throughout the wound surface, combating burn wound pathogens through the hydration effect and thereby enhancing the healing process. However, the presence of eschar formation on burn wounds obstructs the passive diffusion of therapeutics, impairing the efficacy of hydrogel as a wound dressing, particularly in cases of severe burns involving deeper tissue damage. This review focuses on exploring the potential of hydrogel as a carrier for transdermal drug delivery in burn wound treatment. Furthermore, strategies aimed at enhancing the transdermal delivery of therapeutic agents from hydrogel to optimize burn wound healing are also discussed.

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Section: Hydrogels As Transdermal Drug Delivery Carriers For Burn Wou...mentioning

confidence: 99%

Section: Hydrogels As Transdermal Drug Delivery Carriers For Burn Wou...mentioning

confidence: 99%

Section: Strategies To Enhance Transdermal Drug Delivery For Burn Wou...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Goh,

Du,

Peng

et al. 2024

Drug Delivery

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“…Chitosan membranes act as a physical barrier over burn wounds, keeping external pollutants, debris, and infection at bay. In situ, injectable chitosan hydrogels show changes from inflammation to proliferative phase in full-thickness third-degree wounds from burns of Wistar albino rats [ 96 ].…”

Section: Reviewmentioning

confidence: 99%

Chitosan-Based Biomaterial in Wound Healing: A Review

Rajinikanth B,

Rajkumar,

et al. 2024

Cureus

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Wound healing is an evolving and intricate technique that is vital to the restoration of tissue integrity and function. Over the past few decades, chitosan a biopolymer derived from chitin, became known as an emerging biomaterial in the field of healing wounds due to its distinctive characteristics including biocompatibility, biodegradability, affinity to biomolecules, and wound-healing activity. This natural polymer exhibits excellent healing capabilities by accelerating the development of new skin cells, reducing inflammation, and preventing infections. Due to its distinct biochemical characteristics and innate antibacterial activity, chitosan has been extensively researched as an antibacterial wound dressing. Chronic wounds, such as diabetic ulcers and liver disease, are a growing medical problem. Chitosan-based biomaterials are a promising solution in the domain of wound care. The article analyzes the depth of chitosan-based biomaterials and their impact on wound healing and also the methods to enhance the advantages of chitosan by incorporating bioactive compounds. This literature review is aimed to improve the understanding and knowledge about biomaterials and their use in wound healing.

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A 3D bioprinted antibacterial hydrogel dressing of gelatin/sodium alginate loaded with ciprofloxacin hydrochloride

Cao,

Lu,

Chen

et al. 2024

Biotechnology Journal

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Skin plays a crucial role in human physiological functions, however, it was vulnerable to bacterial infection which delayed wound healing. Nowadays, designing an individual wound dressing with good biocompatibility and sustaining anti‐infection capability for healing of chronic wounds are still challenging. In this study, various concentrations of the ciprofloxacin (CIP) were mixed with gelatine (Gel)/sodium alginate (SA) solution to prepare Gel/SA/CIP (GAC) bioinks, following the fabrication of GAC scaffold by an extrusion 3D bioprinting technology. The results showed that the GAC bioinks had good printability and the printed GAC scaffolds double‐crosslinked by EDC/NHS and CaCl2 had rich porous structure with appropriate pore size, which were conducive to drug release and cell growth. It demonstrated that the CIP could be rapidly released by 70% in 5 min, which endowed the GAC composite scaffolds with an excellent antibacterial ability. Especially, the antibacterial activities of GAC7.5 against Escherichia coli and Staphylococcus aureus within 24 h were even close to 100%, and the inhibition zones were still maintained 14.78 ± 0.40 mm and 14.78 ± 0.40 mm, respectively, after 24 h. Meanwhile, GAC7.5 also demonstrated impressive biocompatibility which can promote the growth and migration of L929 and accelerate wound healing. Overall, the GAC7.5 3D bioprinting scaffold could be used as a potential skin dressing for susceptible wounds with excellent antibacterial activity and good biocompatibility to meet urgent clinical needs.

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Current challenges and future applications of antibacterial nanomaterials and chitosan hydrogel in burn wound healing

Abstract: Burns are one of the most devastating skin injuries, with severe burns affecting almost every organ system, and that causes a high mortality rate. The presence of microbial infection in...

Cited by 19 publications

References 210 publications

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Chitosan-Based Biomaterial in Wound Healing: A Review

A 3D bioprinted antibacterial hydrogel dressing of gelatin/sodium alginate loaded with ciprofloxacin hydrochloride

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