Current Aspects on Oral Squamous Cell Carcinoma

Markopoulos, Anastasios K.

doi:10.2174/1874210601206010126

Cited by 393 publications

(350 citation statements)

References 49 publications

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“…Ever use of alcohol was associated with a 1.67 fold increased risk of oral cancer (Anantharaman et al, 2014). However, it is not proved that alcohol use is the risk of OSCC with adjusted p-value 0.063 in our study, which is different from other studies in other countries (Zygogianni et al, 2011;Markopoulos, 2012). It was shown in this study tobacco use and alcohol consumption had a synergistic effect on the development of OSCC in HPV-positive patients.…”

Section: Li-li Gan Et Alcontrasting

confidence: 98%

“…But there is some other controversial definitions need to be clarified. In many documents, scientists tend to classified base of tongue into oropharyngeal and focus on the oropharyngeal squamous cell cancer (Herrero et al, 2003;D'Souza et al, 2007), whereas in other countries, authors tend to classified all oral anatomic site into the oral cancer which included oral cavity and oropharyngeal (Pintos et al, 2008;Markopoulos, 2012). Here, we prefer to the latter classification.…”

Section: Li-li Gan Et Almentioning

confidence: 99%

“…The term OSCC (oral squamous cell carcinoma) tends to be used to describe squamous cell carcinoma of oral cancer (Markopoulos, 2012). OSCC is the most common histologic type (Argiris et al, 2008;Marur et al, 2010), which constitutes about 90% of all oral malignancies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan¹,

Zhang²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Li-li Gan Et Alcontrasting

confidence: 98%

Section: Li-li Gan Et Almentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan¹,

Zhang²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Markopoulos (8) reported that older males, ethnic minority groups and lower socioeconomic groups were more commonly affected by buccal SCC. In the present study, we demonstrated that 38.8% of the patients had a history of alcohol consumption, 61.3% had a history of tobacco product consumption and all patients belonged to low socioeconomic groups.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Fang

Shi

et al. 2013

Molecular and Clinical Oncology

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Abstract. Squamous cell carcinoma (SCC) of the buccal mucosa is a common malignancy in Southeast Asia. The purpose of this study was to present our clinical experience with buccal SCC over a period of 7 years and to analyze the factors associated with surgical outcome. We conducted a retrospective review on 67 buccal SCC patients (between September, 2005 and May, 2011) with tumors restricted to or originating from the buccal mucosa. In a univariate model, nodal stage, degree of tumor differentiation and composite resection were associated with recurrence, while in a multivariate model, the degree of differentiation was the only factor affecting locoregional control. In a survival analysis, recurrence, nodal stage and degree of differentiation were considered as significant factors. Buccal SCC is an aggressive malignant tumor and the degree of differentiation is the most significant factor affecting prognosis and survival. An adequate systemic treatment is required in the case of poorly differentiated tumors. Neck dissection (ND) exerts a positive effect on the locoregional control of buccal SCC staged as cT1-2N0. In the case of identification of positive lymph nodes during surgery, postoperative radiation is recommended in order to improve locoregional control.

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“…Oral squamous cell carcinoma, a cancer of the oral cavity, is one of the ten most common malignant neoplasms and is the 5 th most frequent cancer worldwide (Markopoulos, 2012). The development of oral cancer is usually preceded by distinct precancerous lesions such as leukoplakia, erythroplakia and oral submucous fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Emodin Efficacy on the Akt, Mapk, Erk and DNMT Expression Pattern During Dmba-Induced Oral Carcinoma in Golden Syrian Hamsters

Manimaran

Manoharan

Neelakandan

2016

Afr J Tradit Complement Altern Med

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Background: The present study has evaluated the Emodin efficacy on the Akt, MAPK, ERK and DNMT expression pattern during 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinoma in golden Syrian hamsters, in order to explore its antitumor potential. Materials and methods: Oral tumors were developed in the buccal pouches of golden Syrian hamsters using the carcinogen, DMBA. Results: While the incidence of tumor formation was 100% in hamsters treated with DMBA alone, the tumor formation was not noticed in DMBA+ Emodin treated hamsters. Also, Emodin reduced the severity of precancerous pathological lesions such as dysplasia, in the hamsters treated with DMBA. Emodin administration corrected the abnormalities in the expression pattern of Akt, MAPK, ERK and DNMT in the buccal mucosa of hamsters treated with DMBA. Conclusions:The present study thus suggests that the tumor preventive potential of Emodin is partly related to its modulating effect on the Akt, MAPK, ERK and DNMT expression pattern, as these molecular markers have a pivotal role in the process of cell proliferation, inflammation, invasion, and apoptosis.

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Current Aspects on Oral Squamous Cell Carcinoma

Cited by 393 publications

References 49 publications

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Emodin Efficacy on the Akt, Mapk, Erk and DNMT Expression Pattern During Dmba-Induced Oral Carcinoma in Golden Syrian Hamsters

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