Current Approaches to Venous Ulcers and Compression

Identified were characteristics of individuals with skin damage related to chronic venous disease. Patients with chronic venous disease (n = 164) were evaluated with duplex ultrasound imaging and were placed in classes 4, 5, and 6 according to the CEAP classification. Their findings were compared with 100 class 2 controls. The prevalence of deep venous thrombosis was higher in the study group (23.7%) versus controls (5.1%; P < .0001), as was the prevalence of deep, perforator, and combined patterns of disease (P < .0001, P < .0007, and P < .0001). The mean duration of disease in controls 2 was shorter compared with the study group (P = .0019). The prevalence of reflux and obstruction within the study group was higher than in controls (P = .0021). Skin changes accurately reflect severity of chronic venous disease. Superficial and perforator vein reflux is the major cause of disease.

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“…Previous studies have documented such limbs and identified other etiologies. 60,61 These include skin diseases, inflammation, and malignancy.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Venous Reflux and Obstruction in Patients With Skin Damage Due to Chronic Venous Disease

Labropoulos

Patel

Tiongson

et al. 2007

Vasc Endovascular Surg

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“…Each year in the United State alone, there are 70,000 burn injuries [7] and 600,000–1,500,000 venous leg ulcers injuries [8]. The treatment of wounds costs nearly $20 billion annually in the US [9].…”

Section: Woundsmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

512

418

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Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly. There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable, and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application.

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“…Good wound care and compression therapy will heal majority of small venous ulcers of short duration. [1] Goals of compression therapy are ulcer healing, reduction of pain and edema, and prevention of recurrence. [2] Compression is used for VLU and narrows veins and restores valve competence and reduces ambulatory venous pressure, thus reducing venous reflux (VR).…”

Section: Introductionmentioning

confidence: 99%