Current approaches to trace analysis of pharmaceuticals and personal care products in the environment

Buchberger, Wolfgang

doi:10.1016/j.chroma.2010.10.040

Cited by 219 publications

(115 citation statements)

References 182 publications

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“…PPCPs are suspected to cause elevated rates of cancer, reproductive impairment in humans and other animals and development and spread of antimicrobial resistance [2][3][4]. Recent studies reported that these contaminants do not need to be persistent in the environment to cause negative effects due to their continuous release [1,5,6]. They have been detected in different natural water systems that include rivers, lakes and reservoirs [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Multi-class determination of personal care products and pharmaceuticals in environmental and wastewater samples by ultra-high performance liquid-chromatography-tandem mass spectrometry

Gracia-Lor

Martínez

Sancho

et al. 2012

Talanta

108

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In this work, a multi-class method for the simultaneous determination of 17 emerging contaminants, including pharmaceuticals and personal care products, has been developed.Target analytes were two anti-inflammatories, a lipid regulator agent, two angiotensin II antagonists, two antiepileptic drugs and a diuretic. Among personal care products, four preservatives and five UV filters were included. The method is based on solid-phase extraction (SPE) using Oasis HLB cartridges followed by ultra-high performance liquid chromatographytandem mass spectrometry (UHPLC-MS/MS). Up to three simultaneous transitions per compound were acquired to assure a reliable identification. A detailed study of the extraction process efficiency and matrix effects was carried out in surface water and effluent wastewater.The use of isotope-labeled internal standards (ILIS) was tested to compensate both potential SPE losses during sample extraction and signal suppression/enhancement observed, especially in EWW. Satisfactory correction in all water samples was only ensured when the own analyte ILIS was used. The use of analogues ILIS was a rather useful approach for correction in the majority of the samples tested when analyte ILIS was unavailable. The method was successfully validated in five different surface water (SW) samples and five effluent wastewater (EWW) samples spiked at two concentration levels (0.05 and 0.5 μg/L in SW; 0.1 and 0.5 μg/L in EWW). The developed method was applied to the analysis of 22 samples (SW and EWW) from the Spanish Mediterranean area and 51 reservoir water samples from Colombia. Personal care products were frequently detected, with the highest concentrations corresponding to benzophenone and benzophenone-4 (samples from Spain), and methylparaben (samples from Colombia). Several pharmaceuticals were detected in the Spanish samples, where irbesartan 3 and valsartan -two Angiotensin II antagonists that are not commonly monitored in the aquatic environment -were the compounds most frequently detected.

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Section: Introductionmentioning

confidence: 99%

“…PPCPs enter into the aquatic environment mainly through effluents of wastewater treatment plants (WWTPs) [6]. A few compounds are transformed or retained in the sludge by conventional water treatment processes.…”

Section: Introductionmentioning

confidence: 99%

Multi-class determination of personal care products and pharmaceuticals in environmental and wastewater samples by ultra-high performance liquid-chromatography-tandem mass spectrometry

Gracia-Lor

Martínez

Sancho

et al. 2012

Talanta

108

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“…1 In recent years, the interest in these compounds has increased, with special attention paid to their presence in the aquatic environment. 2 However, there is little information about the adverse effects of human pharmaceuticals on aquatic organisms. 3 Indeed it is known that even though the concentrations found in surface water are very low, the constant introduction of low concentrations represents a risk; compounds such as β-estradiol, carbamazepine and ibuprofen have been shown to have adverse effects on aquatic ecosystems.…”

Section: Introductionmentioning

confidence: 99%

“…3 Indeed it is known that even though the concentrations found in surface water are very low, the constant introduction of low concentrations represents a risk; compounds such as β-estradiol, carbamazepine and ibuprofen have been shown to have adverse effects on aquatic ecosystems. 2 A wide range of analytical methods have been developed for the analysis of PPCPs in aqueous samples. High-performance liquid chromatography (HPLC) with ultraviolet (UV) detection methods are commonly used for the determination of PPCPs in several matrices; 4 gas chromatography-mass spectrometry (GC-MS) is another good alternative, because it can be used to identify these analytes with low limits of detection (LOD).…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry

Giordano

Vásquez

Retamal

et al. 2016

Journal of the Brazilian Chemical Society

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The use of thin-film microextraction for the extraction of selected pharmaceutical compounds followed by gas chromatography-mass spectrometry detection was evaluated. A segment of polysiloxanes polymer sheet was used as low cost, single use, disposable extraction phase, while Milli-Q water spiked at 20 µg L −1 with the analytes was used for the optimization assays. The controlling parameters for the extraction were optimized via experimental design and it was found that an extraction time of 3 h using a sample volume of 1000 mL at pH 4 with the addition of 20% methanol and 20% sodium chloride provided the greatest extraction efficiency. Recoveries between 67.1 and 85.0% were achieved, with a repeteability lower than 20% (expressed as coefficient of variation) and limit of detection ranged from 0.41 and 0.92 µg L −1 . The proposed method show similar analytical performance when compared to the determination of the analytes using stir bar sorptive extraction.

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“…As a result of their occurrence, analytical techniques for trace analysis of wide range pharmaceuticals in water samples, such as wastewater, has been extensively investigated for better efficiency and sensitivity (Buchberger, 2011;Ding et al, 2013;Pailler et al, 2009;Pavlović et al, 2007;Robles-Molina et al, 2014;Yu and Wu, 2011). The concentration of detected pharmaceuticals in wastewater dependson type of treatment used.…”

Section: Introductionmentioning

confidence: 99%

Direct Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid Chromatography

Subari¹,

Osman²,

Saim³

2017

American Journal of Applied Sciences

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In this study, three parameters (sample volume, cleanup and elution step) in large volume injection online Solid Phase Extraction Liquid Chromatography with diode array detection (SPE-LC) were optimized for the determination of six pharmaceuticals in wastewater samples. Preconcentration and separation were carried out using 2 columns, Dionex Ion Pac AG14A and Acclaim Polar Advantage II. Response Surface Methodology (RSM) was employed for the optimization of cleanup step (mobile phase composition and valve switching time). The optimum conditions obtained were as follows: Sample volume of 10.0 mL and cleanup with acetonitrile and ultrapure water (5:95) for 1.0 min. The method showed good recovery (82.91-107.7%), precision (0.35-8.26%) and linearity (R 2 >0.99). The limit of detection was between 3.5 and 11.7 µg L −1 . The proposed method is rapid, simple and sensitive for trace analysis of pharmaceuticals in water samples.

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Current approaches to trace analysis of pharmaceuticals and personal care products in the environment

Cited by 219 publications

References 182 publications

Multi-class determination of personal care products and pharmaceuticals in environmental and wastewater samples by ultra-high performance liquid-chromatography-tandem mass spectrometry

Multi-class determination of personal care products and pharmaceuticals in environmental and wastewater samples by ultra-high performance liquid-chromatography-tandem mass spectrometry

Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry

Direct Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid Chromatography

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