Current approaches for the treatment of male infertility with stem cell therapy

Pourmoghadam, Zahra; Aghebati‐Maleki, Leili; Motalebnezhad, Morteza; Yousefi, Bahman; Yousefi, Mehdi

doi:10.1002/jcp.26577

Cited by 20 publications

(12 citation statements)

References 128 publications

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“…At least 30 million men worldwide suffer from infertility, with the highest prevalence found in Africa and Eastern Europe. However, because of the varying opinions with different credibility and older articles, it is quite difficult to provide accurate statistics [ 3 ]. Infertility is considered one of the main health problems affecting couples in the reproductive age, affecting about 8–12% of couples worldwide [ 4 ], and it was estimated that the prevalence of age-standardized infertility increased by 0.370% in women and by 0.291% in men every year between 1990 and 2017 [ 5 ], according to a global burden of disease survey.…”

Section: Male Infertilitymentioning

confidence: 99%

“…On the other hand, other stem cell types have also been used for azoospermia treatment. For instance, mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), very small embryonic-like stem cells (VSELs), and induced pluripotent stem cells (iPSCs) are obtained from normal somatic cells [ 3 , 83 ].…”

Section: Spermatogonial Stem Cell As New Option To Treat Impaired Spermatogenesismentioning

confidence: 99%

“…However, there is an ethical controversy regarding the use of embryonic stem cells in humans. Moreover, during differentiation, ESCs lose their plasticity [ 3 ]. ESCs differentiate into male germ-like cells in vitro, but the disadvantage is that they are not genetically related to patients [ 96 ].…”

Section: Other Stem Cell Types (Ipscs Escs Vsels and Mscs)mentioning

confidence: 99%

“…The advantages of iPSCs are an easy sampling technique, that is, somatic cells such as skin can be obtained and then reprogrammed to produce germ cells. Therefore, there is currently research underway on iPSCs to differentiate into SSCs in patients that do not have their own SSCs [ 3 , 83 , 132 ]. SSC-like cells (SSCLCs) have been generated from pluripotent stem cells and showed self-renewal over four months of culture [ 163 ].…”

Section: Other Stem Cell Types (Ipscs Escs Vsels and Mscs)mentioning

confidence: 99%

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Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive Azoospermia

Abdelaal

Tanga

Abdelgawad

et al. 2021

Cells

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Male infertility is a major health problem affecting about 8–12% of couples worldwide. Spermatogenesis starts in the early fetus and completes after puberty, passing through different stages. Male infertility can result from primary or congenital, acquired, or idiopathic causes. The absence of sperm in semen, or azoospermia, results from non-obstructive causes (pretesticular and testicular), and post-testicular obstructive causes. Several medications such as antihypertensive drugs, antidepressants, chemotherapy, and radiotherapy could lead to impaired spermatogenesis and lead to a non-obstructive azoospermia. Spermatogonial stem cells (SSCs) are the basis for spermatogenesis and fertility in men. SSCs are characterized by their capacity to maintain the self-renewal process and differentiation into spermatozoa throughout the male reproductive life and transmit genetic information to the next generation. SSCs originate from gonocytes in the postnatal testis, which originate from long-lived primordial germ cells during embryonic development. The treatment of infertility in males has a poor prognosis. However, SSCs are viewed as a promising alternative for the regeneration of the impaired or damaged spermatogenesis. SSC transplantation is a promising technique for male infertility treatment and restoration of spermatogenesis in the case of degenerative diseases such as cancer, radiotherapy, and chemotherapy. The process involves isolation of SSCs and cryopreservation from a testicular biopsy before starting cancer treatment, followed by intra-testicular stem cell transplantation. In general, treatment for male infertility, even with SSC transplantation, still has several obstacles. The efficiency of cryopreservation, exclusion of malignant cells contamination in cancer patients, and socio-cultural attitudes remain major challenges to the wider application of SSCs as alternatives. Furthermore, there are limitations in experience and knowledge regarding cryopreservation of SSCs. However, the level of infrastructure or availability of regulatory approval to process and preserve testicular tissue makes them tangible and accurate therapy options for male infertility caused by non-obstructive azoospermia, though in their infancy, at least to date.

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Section: Male Infertilitymentioning

confidence: 99%

Section: Spermatogonial Stem Cell As New Option To Treat Impaired Spermatogenesismentioning

confidence: 99%

Section: Other Stem Cell Types (Ipscs Escs Vsels and Mscs)mentioning

confidence: 99%

Section: Other Stem Cell Types (Ipscs Escs Vsels and Mscs)mentioning

confidence: 99%

See 2 more Smart Citations

Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive Azoospermia

Abdelaal

Tanga

Abdelgawad

et al. 2021

Cells

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“…In evaluation of hormonal profile, men with testicular deficiencies show hypergonadotrophic hypogonadism, increased levels of follicle stimulating (FSH) and luteinising hormone (LH) with low levels of testosterone. All these play havoc on the normal development of spermatogonia thereby prove very detrimental to the reproductive health of men [8].…”

Section: Introductionmentioning

confidence: 99%

Understanding Male Infertility for Promising ART

Zargar¹,

A²,

Lateef³

et al. 2021

Infertility and Assisted Reproduction

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Infertility is a serious problem of not being able to conceive despite regular intercourse for more than a year. Natural conception is seen to be achieved in 80%–85% of couples. About 15% of couples suffer infertility with male factor contributing to almost 50% of cases. Paradoxically, on traditional assessment, the underlying etiology of male contribution towards infertility remains unrecognized in 30% of the patients and thereby grouped as idiopathic. Diagnostics of male infertility cannot therefore be limited to usual semen analysis only. The spectrum of the recent research encourages the experts in the field to approach the Clinical, Molecular and cytogenetic shades associated with the problem besides secondary factors like life style and environment. Clinical assessment sums the medical history and physical examination of the affected individual. Molecular and cytogenetic analysis help gain new insights in understanding the problem and thereby an advantage for a successful assisted reproductive treatment (ART). Given the cost and burden ART puts in and prior to application of any invasive techniques, understanding precisely the etiology associated with male infertility is essential for the fertility specialist to circumvent inefficient or any unproductive steps in the fertilization process besides helping in counseling patients on their chance of success with the use of reproductive technology.

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Stem cells technology as a platform for generating reproductive system organoids and treatment of infertility‐related diseases

Jahanbani

Shafiee

Davaran

et al. 2021

Cell Biology International

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In recent years, stem cells have known as a helpful biological tool for the accurate diagnosis, treatment and recognition of diseases. Using stem cells as biomarkers have presented high potential in the early detection of many diseases. Another advancement in stem cell technology includes stem cell derived organoids model that could be a promising platform for diagnosis and modeling different diseases.Furthermore, therapeutic capabilities of stem cell therapy have increased hope in the face of different disability managements. All of these technologies are also widely used in reproductive related diseases especially in today's world that many couples encounter infertility problems. However, with the aid of numerous improvements in the treatment of infertility, over 80% of couples who dreamed of having children could now have children. Due to the fact that infertility has many negative effects on personal and social lives of young couples, many researchers have focused on the treatment of male and female reproductive system abnormalities with different types of stem cells, including embryonic stem cells, bone marrow mesenchymal stem cells (MSCs), and umbilical cord-derived MSCs. Also, design and formation of reproductive system organoids provide a fascinating window into disease modeling, drug screening, personalized therapy, and regeneration medicine. Utilizing these techniques to study, model and treat the infertility-related diseases has drawn attention of many scientists. This review explains different applications of stem cells in generating reproductive system organoids and stem cell-based therapies for male and female infertility related diseases treatment.

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Current approaches for the treatment of male infertility with stem cell therapy

Cited by 20 publications

References 128 publications

Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive Azoospermia

Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive Azoospermia

Understanding Male Infertility for Promising ART

Stem cells technology as a platform for generating reproductive system organoids and treatment of infertility‐related diseases

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