“…Autografts provide benefits of initial mechanical stability, highest stiffness in tendon biomechanical constructs available, and reduction in the chance of late rupture; however, issues include surgical and donor site morbidity, finite availability, and inadequate revascularization. 3,6 Allografts, which demonstrate an advantage of no donor site morbidity and similar mechanical strength compared to autografts, have associated challenges including potential for disease transmission and bacterial infections, a limited donor pool, and an increased failure rate (up to 4 times higher) for young, active patients. 7 Thus, the market demand promotes synthetic scaffolds as an ideal solution within the regenerative engineering field.…”