Current approaches and future prospects of nanofibers: a special focus on antimicrobial drug delivery

Topcu, Betul; Gultekinoglu, Merve; Timur, Selin Seda; Eroğlu, İpek; Ulubayram, Kezban; Eroğlu, Hakan

doi:10.1080/1061186x.2020.1867991

Cited by 12 publications

(9 citation statements)

References 96 publications

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“…These findings were consistent with some reports indicating an inverse relationship between electrical conductivity and viscosity. 42 Moreover, normal fiber diameter distribution suggested the achievement of favorable electrospinning conditions. Meanwhile, the minor diameter was obtained in the case of Chitosan nanofibers.…”

Section: Discussionmentioning

confidence: 99%

Development and characterization of the electrospun melittin-loaded chitosan nanofibers for treatment of acne vulgaris in animal model

Rahnama

Movaffagh

Shahroodi

et al. 2022

Journal of Industrial Textiles

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Acne is an inflammatory disease of the sebaceous glands. Melittin (Mel) is one of the principal toxic components of bee venom that can cause antibacterial and anti-inflammatory effects. Chitosan is a biodegradable polysaccharide has anti-inflammatory, antimicrobial, and regenerative properties. In this study, chitosan (Ch)/Mel 0.001 and 0.003% nanofibers were fabricated for topical treatment of acne vulgaris. Physicochemical properties of Ch/Mel were evaluated using FTIR and FESEM. Furthermore, encapsulation efficiency, tensile strength, water absorption capacity, enzymatic activity, drug release, antimicrobial, and cell cytotoxicity were assayed. Animal models were exerted to study the impact of Ch/Mel nanofibers on the treatment of Propionibacterium acnes. The FESEM results showed that nanofibers were successfully prepared in nano-scale fiber diameter. The FTIR confirmed the presence of Mel in structures. The addition of melittin to the polymer solution reduced electrical conductivity, induced viscosity and tensile strength of the fibers, and decreased the percentage of the swelling. The Mel loading into Ch/Mel 0.003% was reported at 86.74±1%. This Mel releasing process (89.65%) of Ch/Mel 0.003% was slowly completed during 72 h. The Mel retained its hemolytic activity after being loaded into the polymer structure. The drug toxicity study displayed the lack of any significant toxicity from Ch/Mel nanofibers on normal Human Dermal Fibroblasts (HDF). The Ch/Mel 0.003% achieved the highest growth inhibition in P. acnes in vitro and animal studies, this group showed the greatest reduction in inflammation and redness. The Ch/Mel 0.003% structure is proposed as a suitable topical drug delivery system for treating acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Development and characterization of the electrospun melittin-loaded chitosan nanofibers for treatment of acne vulgaris in animal model

Rahnama

Movaffagh

Shahroodi

et al. 2022

Journal of Industrial Textiles

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“…The significance of optimizing the release of active constituents from nanofiber architectures cannot be disputed, and for a suitable continuous release target, burst release must be carefully regulated. Layer-by-layer technologies, the incorporation of a hydrophobic and hydrophilic polymer into the framework of nanofibers, and the notion of composite nanofibers have all been investigated to optimize the release characteristic of nanofibers . Thus, some of the challenges associated with these systems include scaling up the technology, producing affordable formulations, tailoring the quantity of drug loading, and regulating the shape and porosity of nanofibers for product uniformity .…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

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Nanotechnology has yielded nanostructure-based drug delivery approaches, among which nanofibers have been explored and researched for the potential topical delivery of therapeutics. Nanofibers are filaments or thread-like structures in the nanometer size range that are fabricated using various polymers, such as natural or synthetic polymers or their combination. The size or diameter of the nanofibers depends upon the polymers, the techniques of preparation, and the design specification. The four major processing techniques, phase separation, self-assembly, template synthesis, and electrospinning, are most commonly used for the fabrication of nanofibers. Nanofibers have a unique structure that needs a multimethod approach to study their morphology and characterization parameters. They are gaining attention as drug delivery carriers, and the substantially vast surface area of the skin makes it a potentially promising strategy for topical drug products for various skin disorders such as psoriasis, skin cancers, skin wounds, bacterial and fungal infections, etc. However, the large-scale production of nanofibers with desired properties remains challenging, as the widely used electrospinning processes have certain limitations, such as poor yield, use of high voltage, and difficulty in achieving in situ nanofiber deposition on various substrates. This review highlights the insights into fabrication strategies, applications, recent clinical trials, and patents of nanofibers for different skin disorders in detail. Additionally, it discusses case studies of its effective utilization in the treatment of various skin disorders for a better understanding for readers.

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“…Less invasive intranasal administration can overcome the BBB and be used for targeting CNS diseases 184 ; cell-penetrating peptide-mediated delivery systems will be useful for this purpose. Additionally, local delivery of miRNAs via viral vectors or nanofibers seems more efficient and less toxic in treating early-stage cancers, whereas for metastatic cancer, more stable and less immunogenic delivery vehicles with high affinity and specificity for cancer sites elicit better responses 63,185 . Furthermore, the use of "cocktail" carriers or multiple simultaneous approaches may increase the transfer efficiency of miRNAs to target cells.…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Modulating microRNAs in cancer: Next-generation therapies

Arghiani

Shah

2021

Cancer Biol Med

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MicroRNAs (miRNAs) are a class of endogenously expressed non-coding regulators of the genome with an ability to mediate a variety of biological and pathological processes. There is growing evidence demonstrating frequent dysregulation of microRNAs in cancer cells, which is associated with tumor initiation, development, migration, invasion, resisting cell death, and drug resistance. Studies have shown that modulation of these small RNAs is a novel and promising therapeutic tool in the treatment of a variety of diseases, especially cancer, due to their broad influence on multiple cellular processes. However, suboptimal delivery of the appropriate miRNA to the cancer sites, quick degradation by nucleases in the blood circulation, and off target effects have limited their research and clinical applications. Therefore, there is a pressing need to improve the therapeutic efficacy of miRNA modulators, while at the same time reducing their toxicities. Several delivery vehicles for miRNA modulators have been shown to be effective in vitro and in vivo. In this review, we will discuss the role and importance of miRNAs in cancer and provide perspectives on currently available carriers for miRNA modulation. We will also summarize the challenges and prospects for the clinical translation of miRNAbased therapeutic strategies.

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Current approaches and future prospects of nanofibers: a special focus on antimicrobial drug delivery

Cited by 12 publications

References 96 publications

Development and characterization of the electrospun melittin-loaded chitosan nanofibers for treatment of acne vulgaris in animal model

Development and characterization of the electrospun melittin-loaded chitosan nanofibers for treatment of acne vulgaris in animal model

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Modulating microRNAs in cancer: Next-generation therapies

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