Current Applications of Diffusion Tensor Imaging and Tractography in Intracranial Tumor Resection

Costabile, Jamie D.; Alaswad, Elsa; D’Souza, Shawn; Thompson, John A.; Ormond, D. Ryan

doi:10.3389/fonc.2019.00426

Cited by 63 publications

(53 citation statements)

References 104 publications

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“…Over the last 15 years, white matter fiber tracking, using diffusion tensor imaging (DTI) has been investigated in different aspects of the surgical management of gliomas [8]. DTI is an in vivo neuroimaging technique that measures anisotropic water diffusion to extract white matter tractography [9].…”

Section: Introductionmentioning

confidence: 99%

Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma

et al. 2019

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Gliomas account for 26.5% of all primary central nervous system tumors. Recent studies have used diffusion tensor imaging (DTI) to extract white matter fibers and the diffusion coefficients derived from MR processing to provide useful, non-invasive insights into the extent of tumor invasion, axonal integrity, and gross differentiation of glioma from metastasis. Here, we extend this work by examining whether a tract-based analysis can improve non-invasive localization of tumor impact on white matter integrity. This study retrospectively analyzed preoperative magnetic resonance sequences highlighting contrast enhancement and DTI scans of 13 subjects that were biopsy-confirmed to have either high or low-grade glioma. We reconstructed the corticospinal tract and superior longitudinal fasciculus by applying atlas-based regions of interest to fibers derived from whole-brain deterministic streamline tractography. Within-subject comparison of hemispheric diffusion coefficients (e.g., fractional anisotropy and mean diffusivity) indicated higher levels of white matter degradation in the ipsilesional hemisphere. Novel application of along-tract analyses revealed that tracts traversing the tumor region showed significant white matter degradation compared to the contralesional hemisphere and ipsilesional tracts displaced by the tumor.

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Section: Introductionmentioning

confidence: 99%

Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma

et al. 2019

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“…9,10 DTI-merged functional neuronavigation could be a useful tool in brain tumor surgery for maximal safe resection. 11,12 Apart from the advantages associated with DTI, there are limitations concerned with DTI, such as lack of gold standard technique available to validate tractography and its reliability. The resolution of DTI may be insufficient which may lead to substantial partial volume effect.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study on Role of DTI in Brain Tumours

Karthika¹,

Anand²,

Vayshak³

et al. 2019

IJCMSR

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Brain tumors are a heterogeneous group of benign and malignant tumors. Preoperative radiological assessment is vital in understanding the extent of disease invasion and planning surgical management. This study is to analyze the role of DTI in assessing the different patterns of white matter involvement in patients with brain tumors. Material and methods: A retrospective study was conducted in thirty patients with brain tumours who had undergone both conventional and diffusion tensor imaging. Based on the imaging, the white matter tracts surrounding the tumours were characterized as either displaced or infiltrated. All the medical records of the people diagnosed with brain tumors between February 2018 to February 2019 were reviewed. Results: A total of 30 subjects were included. The proportion of subjects with low grade and high-grade gliomas was 53.3% and 46.7% respectively. Diffusion tensor imaging had shown invasion in 17 (56.7%) of the subjects. Total resection was done in 17 (56.7%) of the subjects and the remaining 13 (43.3%) underwent subtotal resection. The incidence of all the postoperative complications was higher among subjects with invasion shown in DTI, but none of the differences have shown statistically significant differences. Conclusion: Diffusion tensor imaging is a very useful tool in the pre-operative assessment of white matter involvement in cerebral tumors. The people with invasion shown in pre-operative assessment are more likely to have post-operative neurological deficit.

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“…There are several future works in development. We plan to conduct further multimodal image fusion studies based on the current research; for example, the integration of diffusion tensor imaging (DTI) into the 3D brain model created by FreeSurfer could lead to a more accurate judgment of the relationship between the tumor and surrounding nerve fiber bundles and help surgeons better protect white matter tracts (WMT) [22,23]. In addition, vascular (CTA/MRA, MRV) and skull (CT) models can be fused with the FreeSurfer models, and combined with Sina, these models could help surgeons make more accurate preoperative plans and yield more benefit for surgeon training and patient education.…”

Section: Plos Onementioning

confidence: 99%

A new simple brain segmentation method for extracerebral intracranial tumors

Hou

Yang

et al. 2020

PLoS ONE

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Normal brain segmentation is available via FreeSurfer, Vbm, and Ibaspm software. However, these software packages cannot perform segmentation of the brain for patients with brain tumors. As we know, damage from extracerebral tumors to the brain occurs mainly by way of pushing and compressing while leaving the structure of the brain intact. Threedimensional (3D) imaging, augmented reality (AR), and virtual reality (VR) technology have begun to be applied in clinical practice. The free medical open-source software 3D Slicer allows us to perform 3D simulations on a computer and requires little user interaction. Moreover, 3D Slicer can integrate with the third-party software mentioned above. The relationship between the tumor and surrounding brain tissue can be judged, but accurate brain segmentation cannot be performed using 3D Slicer. In this study, we combine 3D Slicer and Free-Surfer to provide a novel brain segmentation method for extracerebral tumors. This method can help surgeons identify the "real" relationship between the lesion and adjacent brain tissue before surgery and improve preoperative planning.

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Current Applications of Diffusion Tensor Imaging and Tractography in Intracranial Tumor Resection

Cited by 63 publications

References 104 publications

Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma

Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma

A Retrospective Study on Role of DTI in Brain Tumours

A new simple brain segmentation method for extracerebral intracranial tumors

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