This study presents the successful development of printable-microencapsulated
ascorbic acid (AA) for personalized topical delivery using laser printing
technology. Rice flour with a 10% AA content was selected as an encapsulation
material. Hydrophobic nanosilica was used to create negative electrostatic
charges on the microencapsulated surfaces via a high-speed mixture.
This process facilitated the microencapsulated AA fabrication using
a commercial laser printer and produced a well-patterned design with
some minor print defects, such as banding and scattering. The amount
of encapsulated AA per area was 0.28 mg/cm
2
, and the RGB
color code was 0,0,0. An emulsion carrier system comprising pentylene
glycol (P5G) or diethylene glycol monoethyl ether (DEGEE), Tween 20,
oleic acid, and deionized (DI) water at a ratio of 20:30:30:20 was
developed to enhance AA transmission into the skin. The Franz diffusion
cell technique was used to investigate topical absorption on Strat-M
membranes using P5G and DEGEE as enhancers. The steady-state fluxes
were 8.40 (±0.64) and 10.04 (±0.58) μg/h/cm
2
for P5G and DEGEE, respectively. Cytotoxicity tests conducted on
fibroblast cells revealed low cytotoxicity for the encapsulation products
and carriers.