Current and Novel Clinical Approaches for the Treatment of Dentin Hypersensitivity

Pereira, José Carlos; Sales-Peres, Sílvia Helena de Carvalho; Francisconi-dos-Rios, Luciana Fávaro; Calabria, Marcela Pagani; Ishikiriama, Sérgio Kiyoshi; Gillam, DG; Wang, Linda

doi:10.1007/978-3-319-14577-8_8

Cited by 7 publications

(4 citation statements)

References 193 publications

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“…There are numerous over-the-counter (OTC) and professionally applied (in-office) products and techniques available for the treatment of DH. Recently, the use of bioactive glasses in toothpaste formulations has been advocated as a possible long-term solution for managing DH [ 2 ]. Currently, most of the research activity focusses on the hydrodynamic theory as the basis for the therapeutic treatment of DH.…”

Section: Introductionmentioning

confidence: 99%

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Cruz

Hill

Chen

et al. 2018

International Journal of Dentistry

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There are numerous over-the-counter (OTC) and professionally applied (in-office) products and techniques currently available for the treatment of dentine hypersensitivity (DH), but more recently, the use of bioactive glasses in toothpaste formulations have been advocated as a possible solution to managing DH. Aim. The aim of the present study, therefore, was to compare several bioactive glass formulations to investigate their effectiveness in an established in vitro model. Materials and Methods. A 45S5 glass was synthesized in the laboratory together with several other glass formulations: (1) a mixed glass (fluoride and chloride), (2) BioMinF, (3) a chloride glass, and (4) an amorphous chloride glass. The glass powders were formulated into five different toothpaste formulations. Dentine discs were sectioned from extracted human teeth and prepared for the investigation by removing the cutting debris (smear layer) following sectioning using a 6% citric acid solution for 2 minutes. Each disc was halved to provide test and control halves for comparison following the brushing of the five toothpaste formulations onto the test halves for each toothpaste group. Following the toothpaste application, the test discs were immersed in either artificial saliva or exposed to an acid challenge. Results. The dentine samples were analyzed using scanning electron microscopy (SEM), and observation of the SEM images indicated that there was good surface coverage following artificial saliva immersion. Furthermore, although the acid challenge removed the hydroxyapatite layer on the dentine surface for most of the samples, except for the amorphous chloride glass, there was evidence of tubular occlusion in the dentine tubules. Conclusions. The conclusions from the study would suggest that the inclusion of bioactive glass into a toothpaste formulation may be an effective approach to treat DH.

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Section: Introductionmentioning

confidence: 99%

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Cruz

Hill

Chen

et al. 2018

International Journal of Dentistry

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“…This may explain that perhaps the use of probe N° 23 in this study, with sometimes uncontrolled pressure, may introduce errors. It would be more accurate to use the Yeaple probe, which controls the pressure exerted on the dental surface . In this this technique, tactile sensitivity is measured by applying a constant‐pressure Yeaple probe that is calibrated each day it is used.…”

Section: Discussionmentioning

confidence: 99%

Clinical Comparative Evaluation of Nd:YAG Laser and a New Varnish Containing Casein Phosphopeptides‐Amorphous Calcium Phosphate for the Treatment of Dentin Hypersensitivity: A Prospective Study

Chebel

Zogheib

Baba

et al. 2018

Journal of Prosthodontics

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Purpose:The aim of this study was to compare the effect of Nd:YAG laser to that of a new varnish: MI Varnish with RECALDENT (GC), for the treatment of dentin hypersensitivity, with a follow-up of 6 months. Dentinal hypersensitivity was evaluated using a new thermal test never before used on dental tissue. Materials and Methods: A split-mouth design was used where teeth on one side received the same type of treatment. Twelve patients suffering from dentin hypersensitivity were chosen. Fifty-four teeth were divided into 27 pairs. Twenty-seven teeth received the Nd:YAG laser treatment, and the 27 contralateral teeth received MI Varnish application. Five parameters were measured, and the measurements were taken before treatment at baseline (T0), after 1 week (T1), 1 month (T2), 3 months (T3), and 6 months (T4) of the application. Air stimulation to obtain the Schiff air score, the score of discomfort according to the visual analog scale (VAS), the tactile score, and the thermal test that determines the minimum cold-stimulating temperature and the maximum heat-stimulating temperature were all used to assess sensitivity. Statistical analyses of the data were performed, and the significance level was set at p ࣘ 0.05. Exact Fisher tests and Chi-Square tests were conducted to compare percentages. Results: There was a clear decrease in dentin hypersensitivity for both treatments (Nd:YAG laser and MI Varnish) especially between baseline and 1 week, with maintenance of this state through the 6-month follow-up period. The difference between the two treatments was not significant, comparing, over time, the Schiff air score, the thermal test, and the VAS; however, the tactile score was significantly improved 6 months after the application of MI Varnish compared to the laser (p = 0.05). Conclusion: There was no significant difference between the two treatments, Nd:YAG laser and MI Varnish. Both treatments were effective and reduced dentin hypersensitivity immediately after treatment up to 6 months.

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“…Many materials have been applied to dentin to try to occlude the open tubules, including fluoride varnishes, oxalates, bioactive glasses, and nanohydroxyapatite (nHAP). Such materials vary in terms of their resistance to removal by tooth brushing or by acid erosion and in terms of their biocompatibility. , For example, calcium fluoride deposits that are created by fluoride varnishes can be removed by saliva or by mechanical scrubbing, which reduces their protective functions over time. , Glutaraldehyde-containing solutions can precipitate or cross-link proteins but have unfavorable properties including toxicity and allergenicity. , Oxalate-containing materials applied in high concentrations may form deposits to partially occlude tubules; however, repeated applications are often needed, and surface mineral loss is a possible concern . An ideal material for long-lasting dentin occlusion would be stable, not easily removed, and biocompatible.…”

Section: Ntroductionmentioning

confidence: 99%

Calcium-Doped Silica Nanoparticles Mixed with Phosphate-Doped Silica Nanoparticles for Rapid and Stable Occlusion of Dentin Tubules

Cao

Wright

et al. 2021

ACS Appl. Nano Mater.

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Long-term occlusion of dentin tubules is a challenge due to the relatively easy removal of the inorganic or organic materials used to occlude them by abrasion or erosion of the treated surface. To overcome this problem, the current work aimed to develop a combination nanomaterial system to enable rapid and stable occlusion of dentin tubules. A large-sized calciumdoped silica nanomaterial (187 nm, Ca-DMSN-L) and a smallsized phosphate-doped silica nanomaterial (74 nm, P-DMSN-S) were fabricated and mixed (denoted as L + S; dendritic mesoporous silica nanomaterial denoted as DMSN). Rapid and dense occlusion of dentin tubules was achieved by the topical application of this combination nanomaterial paste to the dentin surface. Fast hydroxyapatite growth was induced by contact with artificial saliva over three repeated 1 min applications. The material occluding the dentin tubules demonstrated strong resistance to acid and abrasion. In comparison, a large-sized phosphate-doped silica nanomaterial (187 nm, P-DMSN-L) was also fabricated and mixed with Ca-DMSN-L to form the L + L material. It also achieved rapid occlusion but showed less resistance to acid and abrasion than the L + S material. The design of using large and small combo material (L + S) has considerable potential for the treatment of dentin hypersensitivity by rapidly causing occlusion of dentin tubules.

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Current and Novel Clinical Approaches for the Treatment of Dentin Hypersensitivity

Cited by 7 publications

References 193 publications

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Clinical Comparative Evaluation of Nd:YAG Laser and a New Varnish Containing Casein Phosphopeptides‐Amorphous Calcium Phosphate for the Treatment of Dentin Hypersensitivity: A Prospective Study

Calcium-Doped Silica Nanoparticles Mixed with Phosphate-Doped Silica Nanoparticles for Rapid and Stable Occlusion of Dentin Tubules

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