Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update

Abstract

: In modern dentistry, nanomaterials have strengthened their foothold among tissue engineering strategies for treating bone and dental defects due to a variety of reasons, including trauma and tumors. Besides their finest physiochemical features, the biomimetic characteristics of nanomaterials promote cell growth and stimulate tissue regeneration. The single units of these chemical substances are small-sized particles, usually between 1 to 100 nm, in an unbound state. This unbound state allows particles to constitute aggregates with one or more external dimensions and provide a high surface area. Nanomaterials have brought advances in regenerative dentistry from the laboratory to clinical practice. They are particularly used for creating novel biomimetic nanostructures for cell regeneration, targeted treatment, diagnostics, imaging, and the production of dental materials. In regenerative dentistry, nanostructured matrices and scaffolds help control cell differentiation better. Nanomaterials recapitulate the natural dental architecture and structure and form functional tissues better compared to the conventional autologous and allogenic tissues or alloplastic materials. The reason is that novel nanostructures provide an improved platform for supporting and regulating cell proliferation, differentiation, and migration. In restorative dentistry, nanomaterials are widely used in constructing nanocomposite resins, bonding agents, endodontic sealants, coating materials, and bioceramics. They are also used for making daily dental hygiene products such as mouth rinses. The present article classifies nanostructures and nanocarriers in addition to reviewing their design and applications for bone and dental regeneration.

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

“…Nanomaterials are used as either antimicrobials for their inherent antimicrobial properties or drug delivery systems specifically designed to have affinity to dental surfaces [31]. Silver (Ag), copper oxide (CuO, Cu 2 O, Cu 2 O 3 , and CuO 2 ), zinc oxide (ZnO), titanium oxide (TiO, TiO 2 , and Ti 2 O 3 ), graphene (an allotrope of carbon), quaternary ammonium polyethyleneimine (QA-PEI), chitosan (CH), and silica (SiO 2 ) nanoparticles are examples of numerous nanomaterials that can control biofilm formation [29,[32][33][34][35][36]. Among all, silver nitrate (AgNO 3 ) and silver nanoparticles (AgNPs) are indicated as specific metal nanomaterials with one of the highest capacities to control the oral biofilm [37].…”

The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials

“…is solution is used locally, and silver ions exert their antibacterial effects by breaking the bacterial membrane, denaturing the proteins, and preventing the DNA proliferation [157]. Silver and fluoride both have a key role in the termination of caries progress and sensitivity of tooth [158][159][160][161]. Silver reduces the demineralization speed and boosts the remineralization process [162].…”

Green Synthesize and Characterization of Copper Nanoparticles Using Iranian Propolis Extracts

“…To produce NPs, bacteria found in complex eukaryotic plants can be used to produce ionic nanoparticles (green synthesis). Because heat, pressure, and energy are not required, these bacteria can handle higher production levels [16][17][18][19][20]. A variety of adverse reactions can occur due to toxic chemicals adsorbing onto the surfaces of NPs.…”