Current advances in the detection of neurotransmitters by nanomaterials: An update

Arumugasamy, Shiva Kumar; Chellasamy, Gayathri; Gopi, Sivalingam; Govindaraju, Saravanan; Yun, Kyusik

doi:10.1016/j.trac.2019.115766

Cited by 33 publications

(25 citation statements)

References 114 publications

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“…[12] In the last decade, nanocarbon-based materials like fullerenes, carbon nanotubes, graphene, and nanodiamonds have been utilized in different scientific fields, such as catalysis, biology, medicine, and analytical chemistry. [13] With this regard and the importance of DA detection, electrochemical active nanomaterials are critical for human health to make dopamine detection with precision. [14] Many research groups are doing extensive research on modifying the carbon nanotube surface in which both covalent and non-covalent interactions are considered.…”

Section: Introductionmentioning

confidence: 99%

“…The nanocomposite of an electron‐deficient flat tetrakis‐(etho xycarbonyl) porphyrin copper(II) (Cu‐TECP) and reduced graphene oxide have also been developed [12] . In the last decade, nanocarbon‐based materials like fullerenes, carbon nanotubes, graphene, and nanodiamonds have been utilized in different scientific fields, such as catalysis, biology, medicine, and analytical chemistry [13] . With this regard and the importance of DA detection, electrochemical active nanomaterials are critical for human health to make dopamine detection with precision [14] …”

Section: Introductionmentioning

confidence: 99%

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Nanotube‐Boramidic Acid Derivative for Dopamine Sensing

et al. 2021

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A new sensor, based on boramidic acid-bounded MWCNTs (Multi-walled carbon nanotubes), was synthesized in three simple steps. Modification of the sensor surface was accomplished using boric acid in which the boron atom is adjacent to the NH group. Characterization, electrochemical behaviors, and stability of newly modified nanosensor were completed using SEM (scanning electron microscope), TEM (Transmission electron microscope), CV (cyclic voltammetry), EIS (electron impedance), DTA (Differential thermal analysis), and XPS (X-ray photoelectron spectroscopy). SEM and TEM analysis were confirmed the modified surface of the nanosensor. The stability of the newly synthesized sensor was also designated that the initial weight loss occurred between 50-145°C was corre-sponded to the degradation of both ethylene diamine and boric acid. According to the EIS study, the Nyquist plot of the MWCNTs-NH-B (OH) 2 /GC electrode displayed a 0.435 kΩ Rct with a smaller semicircle than the bare GC (6.57 kΩ). The electrochemical behavior of dopamine was investigated using cyclic and square wave voltammetry (0.1 M phosphate buffer solution-pH 7.4). The diffusion-controlled process was determined when the oxidation of dopamine was studied. The detection limit of dopamine was found to be 5.1 nM. An actual sample study was done using the developed analytical method, and the detection of dopamine in urine was successfully performed. This study is the first example of boramidic acidmodified multi-walled carbon nanotubes

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanotube‐Boramidic Acid Derivative for Dopamine Sensing

et al. 2021

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“…Dopamine (DA) plays a significant role in a human organism. Excess DA can increase a person’s susceptibility to depression and drug addiction [ 3 ]. In contrast, a DA deficiency is highly related to disorders such as schizophrenia, Parkinson’s disease or HIV infection [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, a DA deficiency is highly related to disorders such as schizophrenia, Parkinson’s disease or HIV infection [ 4 , 5 ]. DA always coexists in human fluids in the presence of different analytes, such as uric acid (UA), ascorbic acid (AA) and epinephrine (EP) [ 3 , 6 , 7 ]. Among them, UA is crucial for evaluating health [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Promising Electrochemical Platform for Dopamine and Uric Acid Detection Based on a Polyaniline/Iron Oxide-Tin Oxide/Reduced Graphene Oxide Ternary Composite

et al. 2020

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A ternary polyaniline/Fe2O3-SnO2/reduced graphene oxide (PFSG) nanocomposite was prepared using a simple two-step hydrothermal treatment. The composite was applied as a glassy carbon electrode modifier (GCE) to enhance dopamine (DA) and uric acid (UA) detection. The ternary PFSG composite was compared with its binary precursor Fe2O3-SnO2/reduced graphene oxide (FSG). The influence of the modified GCE electrodes on their performance as a sensing platform was determined. GCE/PFSG showed better sensing parameters than GCE/FSG due to the introduction of polyaniline (PANI), increasing the electrocatalytic properties of the electrode towards the detected analytes. GCE/PFSG enabled the detection of low concentrations of DA (0.076 µM) and UA (1.6 µM). The peak potential separation between DA and UA was very good (180 mV). Moreover, the DA oxidation peak was unaffected even if the concentration of UA was ten times higher. The fabricated sensor showed excellent performance in the simultaneous detection with DA and UA limits of detection: LODDA = 0.15 µM and LODUA = 6.4 µM, and outstanding long-term stability towards DA and UA, holding 100% and 90% of their initial signals respectively, after one month of use.

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“…Advancements in the determination of various neurotransmitters using nanomaterials for optical and electrochemical sensor design and the prospect of these techniques have been reviewed by Chauhan et al [65]. In the same vein, the electrochemical determination of NTs and the mechanism of electron transfer was discussed in a review put together by Arumugasamy et al [66]. A review specific to the challenges involved in the detection of DA in biological samples using chemically modified electrode was done by Sajid et al [67] with special reference to numerous carbon-based electrodes, ionic liquids, polymers, and metal and metal oxide nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Carbon-Based Quantum Dots for Electrochemical Detection of Monoamine Neurotransmitters—Review

et al. 2020

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Imbalance in the levels of monoamine neurotransmitters have manifested in severe health issues. Electrochemical sensors have been designed for their determination, with good sensitivity recorded. Carbon-based quantum dots have proven to be an important component of electrochemical sensors due to their high conductivity, low cytotoxicity and opto-electronic properties. The quest for more sensitive electrodes with cheaper materials led to the development of electrochemical sensors based on carbon-based quantum dots for the detection of neurotransmitters. The importance of monoamine neurotransmitters (NTs) and the good electrocatalytic activity of carbon and graphene quantum dots (CQDs and GQDs) make the review of the efforts made in the design of such sensors for monoamine NTs of huge necessity. The differences and the similarities between these two quantum dots are highlighted prior to a discussion of their application in electrochemical sensors over the last ten years. Compared to other monoamine NTs, dopamine (DA) was the most studied with GQDs and CQD-based electrochemical sensors.

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Current advances in the detection of neurotransmitters by nanomaterials: An update

Cited by 33 publications

References 114 publications

Nanotube‐Boramidic Acid Derivative for Dopamine Sensing

Nanotube‐Boramidic Acid Derivative for Dopamine Sensing

A Promising Electrochemical Platform for Dopamine and Uric Acid Detection Based on a Polyaniline/Iron Oxide-Tin Oxide/Reduced Graphene Oxide Ternary Composite

Carbon-Based Quantum Dots for Electrochemical Detection of Monoamine Neurotransmitters—Review

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