Current Advances in Aptamers for Cancer Diagnosis and Therapy

Hori, Shinichiro; Herrera, Alberto; Rossi, John J.; Zhou, Jiehua

doi:10.3390/cancers10010009

Cited by 139 publications

(109 citation statements)

References 217 publications

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“…But none of these articles have reviewed the emerging aptamers technology in the disease diagnosis of aquatic animal and its potential prophylactic and therapeutic properties. The application of aptamers technology has been studied extensively in the past decades, notably in the diagnosis and therapeutics of human infectious diseases (Singh, Manohar, Adegoke, Stenström, & Shanker, ; Ulrich, Cheffer, & Zimbres, ), as well as cancer (Duan, Wang, Shigdar, & Tran, ; Hori, Herrera, Rossi, & Zhou, ; Mayer, Schöler, & Heidarian, ). To date, the application of aptamers technology in infectious disease diagnosis of aquatic animal is mostly limited to viral infections.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn

Low

Yusoff²,

Kuppusamy³

et al. 2018

Journal of Fish Diseases

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Macrobrachium rosenbergii nodavirus (MrNV) has been threatening the giant freshwater prawn aquaculture since 1997, causing white tail disease in the prawn species that leads to 100% lethality of the infected postlarvae. Comprehension of the viral infectivity and pathogenesis at molecular biology level has recently resolved the viral capsid protein and evidenced the significant difference in the viral structural protein compared to other nodaviruses that infect fish and insect. Cumulative researches have remarked the proposal to assert MrNV as a member of new genus, gammanodavirus to the Nodaviridae family. The significance of molecular biology in MrNV infection is being highlighted in this current review, revolving the viral life cycle from virus binding and entry into host, virus replication in host cell, to virus assembly and release. The current review also highlights the emerging aptamers technology that is also known as synthetic antibody, its application in disease diagnosis, and its prophylactic and therapeutic properties. The future perspective of synthetic virology technology in understanding viral pathogenesis, as well as its potential in viral vaccine development, is also discussed.

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Section: Treatment and Preventionmentioning

confidence: 99%

Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn

Low

Yusoff²,

Kuppusamy³

et al. 2018

Journal of Fish Diseases

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“…However, the efficient and safe delivery of RNAi-based therapeutics into specific tissues or cell populations is still the principal challenge for their clinical development. Thus, the combination of these functional RNAi with oligonucleotide aptamers into a single chimeric molecule has been extensively explored [ 63 , 64 ] and applied to different cancers, including NSCLC.…”

Section: Aptamer-based Conjugates For Targeted Delivery In Nsclcmentioning

confidence: 99%

Advances in Oligonucleotide Aptamers for NSCLC Targeting

Rotoli

Santana-Viera

Ibba

et al. 2020

IJMS

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Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer worldwide, with the highest incidence in developed countries. NSCLC patients often face resistance to currently available therapies, accounting for frequent relapses and poor prognosis. Indeed, despite great recent advancements in the field of NSCLC diagnosis and multimodal therapy, most patients are diagnosed at advanced metastatic stage, with a very low overall survival. Thus, the identification of new effective diagnostic and therapeutic options for NSCLC patients is a crucial challenge in oncology. A promising class of targeting molecules is represented by nucleic-acid aptamers, short single-stranded oligonucleotides that upon folding in particular three dimensional (3D) structures, serve as high affinity ligands towards disease-associated proteins. They are produced in vitro by SELEX (systematic evolution of ligands by exponential enrichment), a combinatorial chemistry procedure, representing an important tool for novel targetable biomarker discovery of both diagnostic and therapeutic interest. Aptamer-based approaches are promising options for NSCLC early diagnosis and targeted therapy and may overcome the key obstacles of currently used therapeutic modalities, such as the high toxicity and patients’ resistance. In this review, we highlight the most important applications of SELEX technology and aptamers for NSCLC handling.

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“…Selections for cell-penetrating aptamers (Tawiah et al 2017) and even selections directly in live animals have also been performed (Mi et al 2010). In recent years, the field has grown exponentially and is increasingly recognized as a powerful biotechnology for biosensing, proteomics, diagnostics, imaging, and targeted drug delivery (Zhou and Rossi 2017;Hori et al 2018).…”

Section: Aptamersmentioning

confidence: 99%

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

Taylor

Houlihan

Holliger

2019

Cold Spring Harb Perspect Biol

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The remarkable physicochemical properties of the natural nucleic acids, DNA and RNA, define modern biology at the molecular level and are widely believed to have been central to life's origins. However, their ability to form repositories of information as well as functional structures such as ligands (aptamers) and catalysts (ribozymes/DNAzymes) is not unique. A range of nonnatural alternatives, collectively termed xeno nucleic acids (XNAs), are also capable of supporting genetic information storage and propagation as well as evolution. This gives rise to a new field of "synthetic genetics," which seeks to expand the nucleic acid chemical toolbox for applications in both biotechnology and molecular medicine. In this review, we outline XNA polymerase and reverse transcriptase engineering as a key enabling technology and summarize the application of "synthetic genetics" to the development of aptamers, enzymes, and nanostructures.

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Current Advances in Aptamers for Cancer Diagnosis and Therapy

Cited by 139 publications

References 217 publications

Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn

Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn

Advances in Oligonucleotide Aptamers for NSCLC Targeting

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

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