Curcumin-whey protein solid dispersion system with improved solubility and cancer cell inhibitory effect

Racz, Levente Zsolt; Tomoaia-Cotişel, Maria; Rácz, Csaba-Pal; Bulieris, Paula V.; Grosu, Ioana Georgeta; Porav, Sebastian; Ciorîță, Alexandra; Filip, Xenia; Martin, Flavia; Şerban, Georgeta; Irina, Kacso; Romania, Molecular Technologies, Donath Str. , Ro Cluj-Napoca,; Pharmacy, Nicolae Jiga str.

doi:10.24193/subbchem.2021.3.13

Cited by 8 publications

(7 citation statements)

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“…The combination of SIL with CCM revealed that it is more effective and efficient in radiation-induced kidney injury than CCM or SIL alone, so it could be used to protect patients during radiotherapy [ 207 ]. This effect could be further enhanced by the complexation of curcumin with protein [ 208 ] or by complexation of beta-cyclodextrins with other different bioactive molecules such as curcumin [ 209 ], quercetin [ 210 ], lipoic acid [ 211 , 212 ], or deferoxamine [ 213 ].…”

Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.

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Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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“…It has begun to be intensively studied due to its biological activity, namely anti-oxidant, anti-inflammatory, anti-cancer, anti-viral, anti-septic, anti-parasitic, analgesic. Due to its ability to protect the liver, the synergistic effect with silymarin is highlighted in the literature [138,139].…”

Section: Silymarin Interaction With Curcuminmentioning

confidence: 99%

Silymarin Based Complexes – a mini review

PALTINEAN¹,

Tomoaia²,

Riga³

et al. 2022

AnnalsARSciBio

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Silymarin (SIL) is a component extracted from Silybum marianum herb and is studied in medicine due to its protective activities on certain organs (liver, kidney, heart, brain). The review discusses some methods that increase silymarin bioavailability such as development of complexes with cyclodextrins, phospholipids, liposome and nanostructured material (hydroxyapatite-HAP). The interactions between SIL and alpha-lipoic acid, metallic nanoparticles (gold nanoparticles-GNP, and silver nanoparticles – SNP), some carotenoids (β-carotene and lycopene) and curcumin were debated too. Some combined treatments (e.g. SIL + curcumin) highlighted anticancer activity against colon cancer cells (DLD-1, HCT116 and LoVo) and protective effect against chemicals toxicity.

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“…Also, it is known to induce apoptosis in prostate cancer cells but also to prevent the progression of this cancer [3]. This proactive compound can form innovative composites and complexes with applications in medicine and in this sense facilitates the understanding of the mechanisms of action during application [4][5][6][7][8][9].…”

Section: Fig 1 Bioactive Compounds From Plantsmentioning

confidence: 99%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

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This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

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Curcumin-whey protein solid dispersion system with improved solubility and cancer cell inhibitory effect

Cited by 8 publications

References 0 publications

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

Silymarin Based Complexes – a mini review

Interaction of Bioactive Compounds With Ceramic Materials – A Review

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