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A bimodal (micro/mesoporous) COF was synthesized by coupling tetrakis-1,3,5,7-(4′-iodophenyl)adamantane with 4,4′-diethynylbiphenyl following a Sonogashira protocol.

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Bis-amidine and bis-carboxylate derivatives have been studied in this work to extend the knowledge of chargeassisted hydrogen bonding (CAHB) which counts among the strongest noncovalent bonding observed so far and arises from the combination of two well-identified types of interactions, namely, electrostatic attraction and hydrogen bonding. The formation of such bridges and the associated formation of macrocycles were screened for substituted (1) and nonsubstituted (2) bis-benzamidines through the use of isomeric proton acceptors aromatic bis-carboxylic (3−6) and bis-sulfonic acids (7−8). A library made from the combination of amidines and carboxylic/sulfonic acids was assessed both in solution and in the solid state. The formation of the CAHB motif was found to be highly dependent on the E,Z isomerization of the amidine moiety. Interesting double dipolar motifs were identified in the solid state.

Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.

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Spirobifluorene‐based porous organic polymers (POP) were synthesized following two different protocols; the acetylenic coupling reaction conditions and the Sonogashira cross‐coupling reaction. These were utilized as support for the hydrogenation of a series of species containing unsaturated C=C and C=O bonds (4‐nitrostyrene, 4‐bromobenzophenone, acetophenone, 7‐nitro‐1‐tetralone and 1,2‐naphtoquinone confirmed their efficiency). POP1 prepared via a copper‐catalysis protocol was completely inactive, while POP2‐4 containing residual Pd exhibited different activities in accordance to the accessibility of the substrates to the metal. Further deposition of 0.5 wt% Pd led to active and stable catalysts. They were easily separated by filtration, and after re‐dispersion, afforded the same performances for ten successive cycles. This study also evidenced the specific role of the support in these reactions by comparing the behavior of Pd/POP with that of a Pd/C catalyst with the same loading of palladium. The deposition of Pt on these supports led to sub‐nanometric particles and, in accordance, to a different catalytic behavior reflected merely by differences in the selectivity.