Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion

Abstract

Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant‐derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin‐mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μ m curcumin, followed by Annexin V/propidium iodide double‐staining assay to evaluate cell apoptosis. Western blot analysis was used to analyze caspase‐3 expression in response to curcumin treatment. Gastrin levels in culture medium were also monitored. Mice bearing gastric cancers were treated with curcumin, followed by analysis of tumor caspase‐3 expression, gastric acid pH , and gastric secretion in serum. Curcumin prominently inhibited gastric cancer cell proliferation and promoted cell apoptosis. Caspase‐3 was upregulated by curcumin treatment. Curcumin also reduced gastrin secretion. Curcumin dramatically inhibited tumor growth, increased gastric pH , and reduced gastric secretion. In gastric cancer, curcumin suppresses gastrin‐mediated acid secretion, which inhibits gastric cancer progression.

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“…Curcumin has been considered as a promising approach for the treatment of multiple cancers, including gastric cancer, bladder cancer, renal cancer, etc [ 6 , 10 – 13 ]. Recently, several researchers also focused on the potential role of curcumin in Rb.…”

“…Currently, multiple therapeutic properties of curcumin have been recognized, including anti-inflammatory, anti-neoplastic [ 6 ], anti-oxidant [ 7 ], anti-fibrotic [ 8 ], and anti-ischemic [ 9 ] effects. Specifically regarding the anti-neoplastic function, curcumin has been reported to suppress the secretion of gastrin-mediated acid, and thereby inhibiting the progression of gastric cancer [ 10 ]. In vitro investigation has showed that curcumin inhibited bladder cancer cells growth and metastasis via regulating β-catenin expression [ 11 ].…”

Increased expression of CART, nNOS, VIP, PACAP, SP and GAL in enteric neurons of the porcine stomach prepyloric region following hydrochloric acid infusion

“…It has been well-documented that disproportionate stress [31,32] or gastrin upregulation [33] underlies the formation of stomach ulcers and excessive secretion of acids is conductive to the development of gastric cancer [34]. Opposing those effects, mucus and bicarbonate secretion form the first line of defense in protecting gastric epithelial cells from acids and digestive enzymes [1,11].…”

Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27

“…In agreement with the reduction of cell viability, treatment with CH-5 increased apoptosis in a dose-dependent manner. We have found in other cell lines that CH-5 is capable of inducing 3/7 caspase activity and then promoting the cleavage of PARP [ 17 , 18 ], and curcumin has already been shown to induce caspases-mediated apoptosis in gastric cancer [ 23 , 24 ]. Thus, CH-5 is likely to trigger apoptosis in gastric cancer cells by the induction of caspases.…”