Curcumin suppresses an endometrial cell inflammation through inhibition of SREBP-1

Kim, So Young; Kyaw, Yi Yi; Seong, Mi So; Kim, Ki Hyung; Cheong, JaeHun

doi:10.15761/imm.1000384

Cited by 4 publications

(2 citation statements)

References 20 publications

(21 reference statements)

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“…to 39 y.o., curcumin was proven to manage endometriosis by inhibiting inflammation through phosphatidylinositol-3-kinase (PI3K)/Akt and sterol regulatory element-binding protein 1 (SREBP-1). This inhibition subsequently blocks COX-2 and nuclear factor kappa B (NFκB), thus the production of various inflammatory cytokines (tumor necrosis factor α, IL-1, IL-2, IL-6, IL-8) is also impaired [29]. Hypoxia-induced inflammation is thought to be substantial in the development and growth of endometriosis.…”

Section: Curcuminmentioning

confidence: 99%

The Role of Herbal Medicine as An Alternative Treatment Option for Endometriosis: A Literature Review

Sutrisno,

Paramadina

2023

a-jhr

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Introduction: Endometriosis is a benign gynecological disorder characterized by ectopic growth of endometrial tissue. This condition may deteriorate patient’s quality of life due to pain as its main manifestation and its complications, including impaired fertility and risk of ovarian cancer. Current standard endometriosis treatment still yields numerous side effects and controversy. Thus, herbal medicine is hoped to be the safer alternative treatment with excellent efficacy for endometriosis. Methods: The search of literature published in English or Bahasa Indonesia was performed by incorporating the search queries “endometriosis”, “herbal therapy”, “silymarin”, “curcumin”, “Viburnum opulus”, “Pueraria”, “Allium sativum”, “black garlic”, “naringenin” on databases including PubMed, Cochrane, Springer, Science Direct, Nature, and Google Scholar. The studies included were in vitro studies, in vivo studies, and clinical trials. Results: Various herbal treatments have been widely studied regarding their anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, cardioprotective, antiallergy, and immunomodulatory capacity. A lot of herbal compounds have the potential to suppress and manage endometriosis through various mechanisms, such as inhibiting the migration and adhesion of endometriosis to other tissues, suppressing inflammatory response in endometriosis pathogenesis, generating antioxidant, inhibiting estrogen activity, and inducing apoptosis of endometriosis cell through a number of signaling pathways. Conclusion: Herbal medicine has the potential to manage endometriosis through various mechanisms. Further research is needed regarding the efficacy of herbal therapy in managing endometriosis.

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Section: Curcuminmentioning

confidence: 99%

The Role of Herbal Medicine as An Alternative Treatment Option for Endometriosis: A Literature Review

Sutrisno,

Paramadina

2023

a-jhr

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“…By modulating immune responses, curcumin may help reduce immune dysregulation and inflammation associated with endometriosis. (Chowdhury et al, 2019;S.Y. Kim et al, 2019).…”

Section: Phytochemicals Reported For Management Of Endometriosismentioning

confidence: 99%

Indian Medicinal Plants for the Management of Endometriosis: A Comprehensive Review on their phytopharmacology

Ekbbal,

Jaiswal,

Aggarwal

et al. 2023

NRFHH

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Endometriosis is a chronic gynecological disorder characterized by the aberrant growth of endometrial tissue outside the uterus, resulting in severe pain and infertility. Conventional treatments often come with limitations and side effects, prompting a quest for alternative therapies. Medicinal plants, integral to traditional medicine systems, have emerged as potential solutions. This review delves into the phytopharmacology and chemistry of medicinal plants employed in endometriosis treatment. An exhaustive search revealed pertinent studies concerning medicinal plant use in endometriosis treatment. These studies were scrutinized for their phytopharmacological attributes and active chemical constituents. Numerous medicinal plants exhibited anti-inflammatory, analgesic, antioxidant, immunomodulatory, and hormone-regulating properties, pivotal in endometriosis management. Mechanisms encompassed the suppression of inflammatory mediators, modulation of estrogen signaling, mitigation of oxidative stress, and enhancement of immune function. Furthermore, key chemical constituents responsible for these effects were pinpointed and classified into classes such as flavonoids, terpenoids, alkaloids, and phenolic compounds. These bioactive agents elicited their actions via diverse molecular targets, including cyclooxygenase enzymes, estrogen receptors, nuclear factor-kappa B, and reactive oxygen species. The findings underscore the potential of medicinal plants as adjunct therapies for endometriosis. Nonetheless, additional preclinical and clinical investigations are imperative to substantiate their efficacy, safety, and optimal dosing. Grasping the phytopharmacology and chemistry of medicinal plants in endometriosis treatment lays the groundwork for novel therapeutic agent development, spotlighting the capacity of natural products to combat this intricate gynecological ailment.

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Therapeutic potential of curcumin in endometrial disorders: Current status and future perspectives

Singh

Dasgupta

Bhattacharya

et al. 2022

Drug Discovery Today

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Curcumin suppresses an endometrial cell inflammation through inhibition of SREBP-1

Cited by 4 publications

References 20 publications

The Role of Herbal Medicine as An Alternative Treatment Option for Endometriosis: A Literature Review

The Role of Herbal Medicine as An Alternative Treatment Option for Endometriosis: A Literature Review

Indian Medicinal Plants for the Management of Endometriosis: A Comprehensive Review on their phytopharmacology

Therapeutic potential of curcumin in endometrial disorders: Current status and future perspectives

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