Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Santos-Parker, Jessica R.; Strahler, Talia R.; Bassett, Candace J.; Bispham, Nina Z.; Chonchol, Michel; Seals, Douglas R.

doi:10.18632/aging.101149

Cited by 123 publications

(91 citation statements)

References 98 publications

(102 reference statements)

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“…Curcumin can effect on blood pressure through different mechanisms such as (a) decrease oxidative stress (Panahi et al, ) (the oxidative stress can effect on the sympathetic activity and cause neurogenic hypertension). (Wu et al, ); (b) reduce inflammatory markers (Jurenka, ; Lee et al, ; Panahi et al, ); (c) increasing nitric oxide bioavailability (improves resistance artery endothelial function) (Santos‐Parker et al, ); (d) inhibit angiotensin‐converting enzyme (Rachmawati et al, ). But in this review, curcumin did not show significant improvement in SBP between intervention and placebo groups.…”

Section: Discussionmentioning

confidence: 99%

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Azhdari

Karandish

Mansoori

2019

Phytotherapy Research

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The finding of studies on the effect of curcumin extract on metabolic factor in patients with metabolic syndrome has had arguable results. This systematic review with meta‐analysis of randomized controlled trials (RCT) aimed to analyze the effect of curcumin/turmeric on metabolic factors in patients with metabolic syndrome. The PICO strategy was used to establish the guiding question of this review. Several databases for RCT were searched until September 2018. Of the 144 articles initially identified, seven trials met the eligibility criteria. A random‐effects model with a mean weight difference (WMD) and a 95% confidence interval was performed for quantitative data synthesis. Pooled estimates of WMD were calculated between intervention and control groups using random‐effects model in the presence of high level of heterogeneity between the studies. The results showed significant improvement of fasting blood glucose (p = 0.01), triglycerides (p < 0.001), high‐density lipoprotein cholesterol (p = 0.003), and diastolic blood pressure (p = 0.007) levels. Curcumin was not associated with a significant change in waist circumference measurement (p = 0.6) and systolic blood pressure level (p = 0.269). Curcumin supplementation improves some components of metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Azhdari

Karandish

Mansoori

2019

Phytotherapy Research

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“…Effect of curcumin on adiponectin and leptin has shown contrasting results with a study by Chuengsamarn et al () showing that administration of curcumin increases adiponectin and reduces leptin significantly at 3 and 6 months (Chuengsamarn et al, ). However, a study by Santos‐Parker et al () did not show any alterations in the levels of inflammatory markers including adiponectin and leptin after 12 weeks of treatment with curcumin (Santos‐Parker et al, ).…”

Section: Discussionmentioning

confidence: 97%

“…The possible reasons for the difference in the two studies could be that the study by Chuengsamarn et al () was done in diabetic patients (Chuengsamarn et al, ) whereas the study by Santos‐Parker et al () was done in healthy participants, where all inflammatory markers including adiponectin and leptin levels did not have any significant effect after 12 weeks of curcumin administration (Santos‐Parker et al, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double‐blind, parallel arm, placebo‐controlled trial

Srinivasan

Selvarajan

Kamalanathan

et al. 2019

Phytotherapy Research

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Diabetes mellitus is characterized by increased central arterial stiffness and endothelial dysfunction leading to increased risk of cardiovascular complications. The aim of this study is to evaluate the effect of Curcuma longa on arterial stiffness and endothelial dysfunction in patients with type 2 diabetes mellitus. This randomized controlled trial was conducted in 136 patients of type 2 diabetes. Among them, 114 completed at least one follow‐up visit and included for data analysis. Arterial stiffness parameters were measured at baseline and every month for 3 months and endothelial dysfunction markers at baseline and after 3 months of treatment with C. longa or placebo. These parameters were compared between the two groups. Both C. longa and placebo groups were comparable at baseline. After 3 months of treatment, C. longa produced significant reduction from baseline in carotid–femoral pulse wave velocity (p = .002), left brachial–ankle pulse wave velocity (p = .001), aortic augmentation pressure (p = .007), aortic augmentation index (p = .007), and aortic augmentation index at heart rate 75 (p = .018) as compared with the placebo group. Three months treatment with C. longa significantly decreases arterial stiffness as compared with placebo in type 2 diabetes mellitus patients.

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“…Trehalose, a disaccharide which has autophagy‐stimulating effects, improves EDD in both older humans and mice, and the aortas from old mice treated with trehalose exhibit lower IL‐1β, IL‐6 and TNF‐α production (LaRocca et al., ). Curcumin, a polyphenol found in turmeric, improves both resistance and conduit artery EDD in older adults independent of changes in systemic CRP, IL‐6 or TNF‐α (Santos‐Parker et al., ). Flaxseed and nut consumption appear to improve arterial function and reduce inflammation in middle‐aged cohorts with cardiovascular and metabolic diseases (Khandouzi, Zahedmehr, Mohammadzadeh, Sanati, & Nasrollahzadeh, ; Neale, Tapsell, Guan, & Batterham, ).…”

Section: Interventions To Ameliorate Age‐related Inflammation and Artmentioning

confidence: 99%

Inflammation as a mediator of arterial ageing

Trott

Fadel

2019

Exp Physiol

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New Findings What is the topic of this review?This review summarizes and synthesizes what is known about the contribution of inflammation to age‐related arterial dysfunction. What advances does it highlight?This review details observational evidence for the relationship of age‐related inflammation and arterial dysfunction, insight from autoimmune inflammatory diseases and their effects on arterial function, interventional evidence linking inflammation and age‐related arterial dysfunction, insight into age‐related arterial inflammation from preclinical models and interventions to ameliorate age‐related inflammation and arterial dysfunction. Abstract Advanced age is a primary risk factor for cardiovascular disease, the leading cause of death in the industrialized world. Two major components of arterial ageing are stiffening of the large arteries and impaired endothelium‐dependent dilatation in multiple vascular beds. These two alterations are major contributors to the development of overt cardiovascular disease. Increasing inflammation with advanced age is likely to play a role in this arterial dysfunction. The purpose of this review is to synthesize what is known about inflammation and its relationship to age‐related arterial dysfunction. This review discusses both the initial observational evidence for the relationship of age‐related inflammation and arterial dysfunction and the evidence that inflammatory autoimmune diseases are associated with a premature arterial ageing phenotype. We next discuss interventional and mechanistic evidence linking inflammation and age‐related arterial dysfunction in older adults. We also attempt to summarize the relevant evidence from preclinical models. Lastly, we discuss interventions in both humans and animals that have been shown to ameliorate age‐related arterial inflammation and dysfunction. The available evidence provides a strong basis for the role of inflammation in both large artery stiffening and impairment of endothelium‐dependent dilatation; however, the specific inflammatory mediators, the initiating factors and the relative importance of the endothelium, smooth muscle cells, perivascular adipose tissue and immune cells in arterial inflammation are not well understood. With the expansion of the ageing population, ameliorating age‐related arterial inflammation represents an important potential strategy for preserving vascular health in the elderly.

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Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Cited by 123 publications

References 98 publications

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double‐blind, parallel arm, placebo‐controlled trial

Inflammation as a mediator of arterial ageing

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