2017
DOI: 10.18632/aging.101149
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Abstract: We hypothesized that curcumin would improve resistance and conduit artery endothelial function and large elastic artery stiffness in healthy middle-aged and older adults. Thirty-nine healthy men and postmenopausal women (45-74 yrs) were randomized to 12 weeks of curcumin (2000 mg/day Longvida®; n=20) or placebo (n=19) supplementation. Forearm blood flow response to acetylcholine infusions (FBFACh; resistance artery endothelial function) increased 37% following curcumin supplementation (107±13 vs. 84±11 AUC at … Show more

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Cited by 123 publications
(91 citation statements)
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References 98 publications
(102 reference statements)
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“…Curcumin can effect on blood pressure through different mechanisms such as (a) decrease oxidative stress (Panahi et al, ) (the oxidative stress can effect on the sympathetic activity and cause neurogenic hypertension). (Wu et al, ); (b) reduce inflammatory markers (Jurenka, ; Lee et al, ; Panahi et al, ); (c) increasing nitric oxide bioavailability (improves resistance artery endothelial function) (Santos‐Parker et al, ); (d) inhibit angiotensin‐converting enzyme (Rachmawati et al, ). But in this review, curcumin did not show significant improvement in SBP between intervention and placebo groups.…”
Section: Discussionmentioning
confidence: 99%
“…Curcumin can effect on blood pressure through different mechanisms such as (a) decrease oxidative stress (Panahi et al, ) (the oxidative stress can effect on the sympathetic activity and cause neurogenic hypertension). (Wu et al, ); (b) reduce inflammatory markers (Jurenka, ; Lee et al, ; Panahi et al, ); (c) increasing nitric oxide bioavailability (improves resistance artery endothelial function) (Santos‐Parker et al, ); (d) inhibit angiotensin‐converting enzyme (Rachmawati et al, ). But in this review, curcumin did not show significant improvement in SBP between intervention and placebo groups.…”
Section: Discussionmentioning
confidence: 99%
“…Effect of curcumin on adiponectin and leptin has shown contrasting results with a study by Chuengsamarn et al () showing that administration of curcumin increases adiponectin and reduces leptin significantly at 3 and 6 months (Chuengsamarn et al, ). However, a study by Santos‐Parker et al () did not show any alterations in the levels of inflammatory markers including adiponectin and leptin after 12 weeks of treatment with curcumin (Santos‐Parker et al, ).…”
Section: Discussionmentioning
confidence: 97%
“…The possible reasons for the difference in the two studies could be that the study by Chuengsamarn et al () was done in diabetic patients (Chuengsamarn et al, ) whereas the study by Santos‐Parker et al () was done in healthy participants, where all inflammatory markers including adiponectin and leptin levels did not have any significant effect after 12 weeks of curcumin administration (Santos‐Parker et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…Trehalose, a disaccharide which has autophagy‐stimulating effects, improves EDD in both older humans and mice, and the aortas from old mice treated with trehalose exhibit lower IL‐1β, IL‐6 and TNF‐α production (LaRocca et al., ). Curcumin, a polyphenol found in turmeric, improves both resistance and conduit artery EDD in older adults independent of changes in systemic CRP, IL‐6 or TNF‐α (Santos‐Parker et al., ). Flaxseed and nut consumption appear to improve arterial function and reduce inflammation in middle‐aged cohorts with cardiovascular and metabolic diseases (Khandouzi, Zahedmehr, Mohammadzadeh, Sanati, & Nasrollahzadeh, ; Neale, Tapsell, Guan, & Batterham, ).…”
Section: Interventions To Ameliorate Age‐related Inflammation and Artmentioning
confidence: 99%