Effect of <i>Curcuma longa</i> on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double‐blind, parallel arm, placebo‐controlled trial

Srinivasan, Akila; Selvarajan, Sandhiya; Kamalanathan, Sadishkumar; Kadhiravan, Tamilarasu; Lakshmi, Nakka Chandrasekhar Prasanna; Adithan, Surendiran

doi:10.1002/ptr.6381

Cited by 26 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Srinivasan et al. ( 35 ) showed that intervention with Curcuma longa produced a significant reduction in arterial stiffness in T2DM patients. The carotid-femoral pulse wave velocity (PWV), left brachial-ankle PWV, aortic augmentation pressure, aortic augmentation index, and aortic augmentation index decrease significantly.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Curcuma longa significantly reduced FBG (−10 mg/dl; −15 to −5), fasting insulin (as insulin sensitizer; −2 mIU/L; −3 to −1), TC (−13 mg/dl; −20 to −6), and LDL-C (−10 mg/dl; −14 to −5), and increased fasting C-peptide (as insulin sensitizer; 0.6 ng/ml; 0.33–0.87) (see Figure 15 ). ( Usharani et al, 2008 ; Na et al, 2013 ; Chuengsamarn et al, 2014 ; Panahi et al, 2017 ; Panahi et al, 2018 ; Adab et al, 2019 ; Adibian et al, 2019 ; Srinivasan et al, 2019 ; de Sousa et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

Introduction: Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM.Objective: The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM.Inclusion criteria: Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults.Methods: The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI).Results: Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced using Aegle marmelos (L.) Corrêa (MD -1.6%; 95% CI −3 to −0.3), Boswellia serrata Roxb. (−0.5; −0.7 to −0.4), Gynostemma pentaphyllum (Thunb.) Makino (−1; −1.5 to −0.6), Momordica charantia L. (−0.3; −0.4 to −0.1), Nigella sativa L. (−0.4; −0.6 to −0.1), Plantago ovata Forssk. (−0.9; −1.4 to −0.3), Tinospora cordifolia (Willd.) Hook.f. and Thomson (−0.5; −0.6 to −0.5), Trigonella foenum-graecum L. (−0.6; −0.9 to −0.4), and Urtica dioica L. (−1.3; −2.4 to −0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4–56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract.Conclusion: The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported.

show abstract

“…Apart from lowering the blood glucose levels, the intake of turmeric also reduces complications resulting from diabetes such as cardiovascular disease and retinal neuropathy. Srinivasan et al conducted a three-month randomizedcontrolled trial with C. longa L. which reported arterial stiffness was reduced significantly as compared with placebo in type 2 diabetes mellitus patients [37]. Banafshe et al's study [38] on diabetic rats has shown turmeric administration resulted in a protective effect against retinal neuropathy, overall demonstrating the protective effects of turmeric for various internal body systems.…”

Section: Turmeric and Diabetesmentioning

confidence: 99%

Systematic Review of Medicinal Plants Used for Treatment of Diabetes in Human Clinical Trials: An ASEAN Perspective

Salleh

Zulkipli

Yasin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Traditionally, there are some medicinal plants believed to treat diabetes, as they have been proven in research studies to possess antidiabetic properties, such as improved insulin sensitivity and hypoglycemic activities, due to their high level of phenolic compounds, flavonoids, terpenoids, alkaloids, and glycosides. We conducted a systematic review to identify potential medicinal plants used during human clinical trials in the Association of Southeast Asian Nation (ASEAN) countries on prediabetic or type 2 diabetic individuals and to potentially identify any bioactive compounds involved in effectively treating symptoms of diabetes such as lowering of blood glucose. A total of 1209 reference titles were retrieved from four selected databases (Science Direct, Scopus, Springer Link, and PubMed) and only three met the inclusion criteria. Upon evaluation of the selected articles, four medicinal plants were identified: turmeric (Curcuma longa), garlic (Allium sativum L.), bitter melon (Momordica charantia), and Rosella flower (Hibiscus sabdariffa L.). Of these, only the bitter melon study did not show any significant change in the blood glucose of participants after intervention. This review demonstrates the limitations in published articles of human clinical trials for medicinal plants’ intervention for diabetes. Upon further investigations on the four identified medicinal plants included in the animal studies, the findings showed positive effects in the management of diabetes, such as hyperglycemia. Hence, further testing and standardization of the methods in the studies can be suggested for human clinical trials for reliable data collections such as methods of extract preparation, duration of intervention, and conditions set for the study design.

show abstract

Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double‐blind, parallel arm, placebo‐controlled trial

Cited by 26 publications

References 37 publications

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

Systematic Review of Medicinal Plants Used for Treatment of Diabetes in Human Clinical Trials: An ASEAN Perspective

Contact Info

Product

Resources

About