Curcumin reduced gold nanoparticles synergistically induces ROS mediated apoptosis in MCF-7 cancer cells

Kondath, Sindhu; Rajaram, Rama; Rajaram, A.

doi:10.1080/24701556.2020.1870496

Cited by 12 publications

(3 citation statements)

References 47 publications

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“…Balakrishnan et al found that gold quercetin nanoparticle conjugations (AuNPs-Qu-5) inhibited EGFR and the PI3K/Akt/mTOR/GSK-2β pathway, accompanied by induced positive upregulation of Bax and Caspase-3 and negative upregula-tion of Bcl-2, resulting in a significant increase in apoptosis and nuclear condensation compared with free Quercetin. In addi-tion, there was a substantial difference in EMT markers such as vimentin, N-cadherin, Snail, Slug, Twist, and E-cadherin protein expression in response to AuNPs-Qu-5, inhibiting migration and invasion of MCF-7 and MDA-MB cells [143].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 92%

Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection

Salazar-Campos,

Ruiz

et al. 2024

Preprint

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In recent times, using image-based deep learning techniques has been very useful for classifying fruits. However, mango is a particular challenge because its shelf life is directly related to the degree of maturity at the time of harvest, which is determined mainly through the visual assessment of the operators when sorting them, doing it incorrectly, coupled with the blows and compressions exposed during storage and transport, trigger the deterioration in their quality, hence the importance of this operation. In this sense, the purpose of this study focuses on designing a computational model based on Deep Learning that uses a convolutional neural network (CNN) parameterized to select mangoes according to their color tone based on their maturity stage. A dataset was established from 201 labeled images, then a CNN architecture was built, obtaining a model on which 3 criteria were evaluated: the number of convolution and grouping layers, the resolution of the input images and the number of training epochs required. As a result, an input image resolution of 32 x 32 pixels was achieved, the process included a convolution layer followed by pooling that fed another layer that processed the results and ended in an output layer with 2 neurons under the One Hot Encoding representation. The model required 20 epochs to perfect its training, achieving 96.04 % accuracy in mango image selection. This study supports the potential of CNNs in quality analysis through mango color selection, even in uncertainty scenarios.

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Section: Magnetic Nanoparticlesmentioning

confidence: 92%

Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection

Salazar-Campos,

Ruiz

et al. 2024

Preprint

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“…To support these findings, several in vitro studies proved cytotoxicity and increased uptake of curcumin-functionalized gold nanoparticles (curcumin-Au NPs) in human prostate cancer cell culture [156]. Moreover, antiproliferative and apoptotic effects on colon and breast human cancer cell lines [157] and a synergistic effect produced by both the gold core and curcumin that triggers the generation of ROS, which consequently initiates the apoptotic pathway with the release of protein Bax, activation of PARP cleavage, and DNA fragmentation, were observed [158].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 94%

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

2021

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Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to the use of this compound. Poor absorption, fast metabolism, and rapid systemic clearance are the most important factors contributing to low curcumin levels in plasma and tissues. Accordingly, to overcome these issues, numerous strategies have been proposed and are investigated in this article. Due to advances in the drug delivery field, we describe here the most promising strategies for increasing curcumin bioavailability, including the use of adjuvant, complexed/encapsulated curcumin, specific curcumin formulations, and curcumin nanoparticles. We analyze current strategies, already available in the market, and the most advanced technologies that can offer a future perspective for effective curcumin formulations. We focus the attention on the effectiveness of curcumin-based formulations in clinical trials, providing a comprehensive summary. Clinical trial results, employing various delivery methods for curcumin, showed that improved bioavailability corresponds to increased therapeutic efficacy. Furthermore, advances in the field of nanoparticles hold great promise for developing curcumin-based complexes as effective therapeutic agents. Summarizing, suitable delivery methods for this polyphenol will ensure the possibility of using curcumin-derived formulations in clinical practice as preventive and disease-modifying therapeutics.

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“…Otherwise, gold–quercetin nanoparticle conjugations (AuNPs-Qu-5) inhibited EGFR and the PI3K/Akt/mTOR/GSK-2β pathway, accompanied by induced positive upregulation of Bax and caspase-3 and negative upregulation of Bcl-2, resulting in a significant increase in apoptosis and nuclear condensation compared with free quercetin. In addition, there was a substantial difference in EMT markers such as vimentin, N-cadherin, Snail, Slug, Twist, and E-cadherin protein expression in response to AuNPs-Qu-5, inhibiting the migration and invasion of MCF-7 and MDA-MB cells [ 143 ].…”

Section: Quercetin Particularitiesmentioning

confidence: 99%

Quercetin, a Flavonoid with Great Pharmacological Capacity

Carrillo-Martinez,

Flores-Hernández,

Salazar-Montes

et al. 2024

Molecules

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Quercetin is a flavonoid with a low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. Quercetin has a potent antioxidant capacity, being able to capture reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive chlorine species (ROC), which act as reducing agents by chelating transition-metal ions. Its structure has five functional hydroxyl groups, which work as electron donors and are responsible for capturing free radicals. In addition to its antioxidant capacity, different pharmacological properties of quercetin have been described, such as carcinostatic properties; antiviral, antihypertensive, and anti-inflammatory properties; the ability to protect low-density lipoprotein (LDL) oxidation, and the ability to inhibit angiogenesis; these are developed in this review.

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Curcumin reduced gold nanoparticles synergistically induces ROS mediated apoptosis in MCF-7 cancer cells

Cited by 12 publications

References 47 publications

Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection

Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Quercetin, a Flavonoid with Great Pharmacological Capacity

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