Curcumin pretreatment attenuates brain lesion size and improves neurological function following traumatic brain injury in the rat

Samini, Fariborz; Samarghandian, Saeed; Borji, Abasalt; Mohammadi, Gholamreza; bakaian, Mahdi

doi:10.1016/j.pbb.2013.07.019

Cited by 70 publications

(55 citation statements)

References 41 publications

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“…Phytochemical studies showed that of the many chemical constituents isolated from Alpinia, diaryheptanods, are among the characteristic compounds [56]. Curcumin, a well-known diarylheptanoid, has been postulated to be of potential use not only in cancer chemo-prevention but also in chemotherapy [57]. Two new diarylheptanoids 1, 2 together with two known analogs 3, 4 were isolated from the rhizomes of Alpinia officinarum.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Samarghandian

Hadjzadeh

Afshari

et al. 2014

BMC Complement Altern Med

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BackgroundWe investigated the potential of galangal rhizomes to induce cytotoxic and apoptotic effects in the cultured human breast carcinoma cell line, (MCF-7) in compare with the non-malignant (MRC-5) cells.MethodsBoth cells were cultured in DMEM medium and treated with galangal rhizomes for three consecutive days. The percentage of apoptotic cells was determined by flow cytometry using Annexin-V fluorescein isothiocyanate.ResultsThe results showed that the ethanolic extract of galangal rhizomes decreased cell viability in the malignant cells as a concentration- and time- dependent manner. The IC50 values against MCF-7 were determined at 400.0 ± 11.7 and 170.0 ± 5.9 μg/ml after 48 and 72 h respectively. The morphology of MCF-7 cells treated with the ethanolic extract confirmed the cell proliferation assay results. Alpinia galanga induced apoptosis in MCF-7 cells, as determined by flow cytometry.ConclusionsWe concluded that the extract of Alpinia galanga exerts pro-apoptotic effects in a breast cancer-derived cell line and could be considered as a potential chemotherapeutic agent in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Samarghandian

Hadjzadeh

Afshari

et al. 2014

BMC Complement Altern Med

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“…Flavonoids are also the main polyphenolic ingredients that express a wide range of biological activities, such as anti-inflammatory, antithrombotic, antioxidant, antiallergic, antibacterial, analgesic, and vasodilatory effects. 1-9 …”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Chrysin Against Drugs and Toxic Agents

2017

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Issues:Polyphenolic compounds, especially flavonoids, are known as the most common chemical class of phytochemicals, which possess a multiple range of health-promoting effects. Flavonoids are ubiquitous in nature. They are also present in food, providing an essential link between diet and prevention of several diseases.Approach:Chrysin (CH), a natural flavonoid, was commonly found in propolis and honey and traditionally used in herbal medicine. A growing body of scientific evidence has shown that CH possesses protective effects against toxic agents in various animal tissues, including brain, heart, liver, kidney, and lung.Key Findings:This study found that CH may be effective in disease management induced by toxic agents. However, due to the lack of information on human, further studies are needed to determine the efficacy of CH as an antidote agent in human.Conclusion:The present article aimed to critically review the available literature data regarding the protective effects of CH against toxic agent–induced toxicities as well as its possible mechanisms.

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“…Ironically, DHA is poorly consumed in India based on the vegetarian prevalence in the population. Turmeric contains the polyphenolic secondary metabolite curcumin, which has been implicated to improve brain health including reducing degeneration in Alzheimer’s disease [19, 37–39], ischemia [40] and traumatic brain injury [22, 41–43]. In addition to having profound antioxidant and anti-inflammatory effects in various tissues [44][45][46][47][48][49][50], we recently showed that curcumin prevents reduced DHA content in the brain following brain trauma, benefiting brain plasticity as well as reducing oxidative damage [22].…”

Section: Introductionmentioning

confidence: 99%

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Noble

Tyagi

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Dietary deficiency of docosahexaenoic acid (C22: 6n-3; DHA) is linked to the neuropathology of several cognitive disorders, including anxiety. DHA, which is essential for brain development and protection, is primarily obtained through the diet or synthesized from dietary precursors, however the conversion efficiency is low. Curcumin (diferuloylmethane), which is a principal component of the spice turmeric, complements the action of DHA in the brain, and this study was performed to determine molecular mechanisms involved. We report that curcumin enhances the synthesis of DHA from its precursor, α-linolenic acid (C18: 3n-3; ALA) and elevates levels of enzymes involved in the synthesis of DHA such as FADS2 and elongase 2 in both liver and brain tissue. Furthermore, in vivo treatment with curcumin and ALA reduced anxiety-like behavior in rodents. Taken together, these data suggest that curcumin enhances DHA synthesis, resulting in elevated brain DHA content. These findings have important implications for human health and the prevention of cognitive disease, particularly for populations eating a plant-based diet or who do not consume fish, a primary source of DHA, since DHA is essential for brain function and its deficiency is implicated in many types of neurological disorders.

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Curcumin pretreatment attenuates brain lesion size and improves neurological function following traumatic brain injury in the rat

Cited by 70 publications

References 41 publications

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Protective Effects of Chrysin Against Drugs and Toxic Agents

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

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