Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: Systematic review and meta-analysis of randomized controlled trials

Melo, Ingrid Sofia Vieira de; Santos, Aldenir Feitosa dos; Bueno, Nassib Bezerra

doi:10.1016/j.phrs.2017.09.010

Cited by 45 publications

(28 citation statements)

References 35 publications

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“…Preclinical studies indicate that curcumin (various dose ranges, 60–300 mg/kg body weight) has the potential to regulate oxidative enzymes, suppress expression of pro-inflammatory cytokines, decrease hepatic glucose production and inhibit glycogenolysis by increasing the activation of AMPK, thereby, providing several putative mechanisms by which curcumin can control blood glucose levels 26 . Substantiating these reports, a recent meta-analysis 15 with eleven randomised controlled trials, indicated that four or more weeks of supplementation with curcumin/and curcuminoids supplementation can effectively reduce the fasting glucose (−8.88, 95% CI: [−5.04 to −2.72] mg/dL, p = 0.005) and glycated haemoglobin levels (−0.54, 95% CI: [−1.09 to −0.002]%, p = 0.049). However, the exact mechanisms by which curcumin exhibits these clinical effects is still not clear.…”

Section: Discussionmentioning

confidence: 93%

“…These effects were hypothesised to be mediated via lowering of low grade inflammation via down-regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) 8 , cytoprotection of pancreatic β-cells by increasing the concentrations of anti-oxidant enzymes 9 and via increasing expression of 5′ adenosine monophosphate-activated protein kinase (AMPK) 10 , a key regulator of glucose and lipid homeostasis. Clinical trials with curcumin supplementation reported positive 11 and no effect 12 on fasting glycaemic parameters in high risk and individuals with type 2 diabetes 13 – 15 . In addition, In-vitro studies demonstrated potent inhibitory effects of curcuminoids and its synthetic analogues on α-glucosidase enzyme and α-amylase, the key regulators of carbohydrate digestion 16 , 17 linking curcumin and curcuminoids to PBG control.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study

Thota

Dias

Abbott

et al. 2018

Sci Rep

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In the current study, we aimed to evaluate the effects of a single dose of curcumin and/or fish oil on postprandial glycaemic parameters in healthy individuals. This was a randomised, placebo-controlled and crossover study. Sixteen (n = 16) volunteers were randomised to receive placebo, curcumin (180 mg) tablets, fish oil (1.2 g long chain omega-3 polyunsaturated fatty acids) capsules and curcumin + fish oil prior to a standard meal on 4 test days separated by a week. Blood glucose, serum insulin and triglycerides were measured at intervals between 0–120 min. Difference between the treatments was measured using two-way repeated measures analysis of variance and pair-wise comparisons using Wilcoxon signed-rank or paired t-test as appropriate. Postprandial glucose concentrations were significantly lower in the curcumin (60.6%, P = 0.0007) and curcumin + fishoil group (51%, P = 0.002) groups at 60 min from baseline. Compared with placebo, area under the curve (AUC) for change in blood glucose concentration was reduced by curcumin (36%, P = 0.003) and curcumin + fishoil (30%, 0.004), but not fish oil alone (p = 0.105). Both curcumin (P = 0.01) and curcumin + fishoil (P = 0.03) treatments significantly lowered postprandial insulin (AUC) by 26% in comparison with placebo. Curcumin, but not fish oil, reduces postprandial glycaemic response and insulin demand for glucose control.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study

Thota

Dias

Abbott

et al. 2018

Sci Rep

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“…The turmeric in a study on NAFLD patients significantly reduced, HOMA-R, FBS, and FBI [22]. Several reviews have reported the beneficial effects of curcumin on the glucose indices (FBS, HbA1c) [23, 24, 33, 34]. Some mechanisms were decreasing inflammatory factors, glucose production, glycogenolysis, insulin resistance, adipocytes, FM, weight and increasing antioxidant activity, glucose uptake, catabolism, and insulin sensitivity [24, 33, 35, 36].…”

Section: Discussionmentioning

confidence: 99%

Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial

et al. 2019

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BackgroundSince lifestyle changes are main therapies for non-alcoholic fatty liver disease (NAFLD), changing dietary components (nutritional or bioactive) may play a parallel important role. Few studies have assessed the effects of curcumin on NAFLD (mainly antioxidant and anti-inflammatory effects). We aimed to determine the effects of nano-curcumin (NC) on overweight/obese NAFLD patients by assessing glucose, lipids, inflammation, insulin resistance, and liver function indices, especially through nesfatin.MethodsThis double-blind, randomized, placebo-controlled clinical trial was conducted in the Oil Company Central Hospital, Tehran. 84 overweight/obese patients with NAFLD diagnosed using ultrasonography were recruited according to the eligibility criteria (age 25–50 yrs., body mass index [BMI] 25–35 kg/m2). The patients were randomly divided into two equal NC (n = 42) and placebo (n = 42) groups. Interventions were two 40 mg capsules/day after meals for 3 months. Lifestyle changes were advised. A general questionnaire, a 24-h food recall (at the beginning, middle and end), and the short-form international physical activity questionnaire (at the beginning and end) were completed. Also, blood pressure, fatty liver degree, anthropometrics, fasting blood sugar (FBS) and insulin (FBI), glycated hemoglobin (HbA1c), homeostasis model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), tumor necrosis factor-alpha (TNF-α), high sensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), liver transaminases, and nesfatin were determined at the beginning and end.ResultsNC compared with placebo significantly increased HDL, QUICKI, and nesfatin and decreased fatty liver degree, liver transaminases, waist circumference (WC), FBS, FBI, HbA1c, TG, TC, LDL, HOMA-IR, TNF-α, hs-CRP, and IL-6 (P < 0.05). The mean changes in weight, BMI, body composition (BC), and blood pressure were not significant (P > 0.05). After adjustment for confounders, the changes were similar to the unadjusted model.ConclusionNC supplementation in overweight/obese NAFLD patients improved glucose indices, lipids, inflammation, WC, nesfatin, liver transaminases, and fatty liver degree. Accordingly, the proposed mechanism for ameliorating NAFLD with NC was approved by the increased serum nesfatin and likely consequent improvements in inflammation, lipids, and glucose profile. Further trials of nano-curcumin’s effects are suggested.Trial registrationIranian Registry of Clinical Trials, IRCT2016071915536N3. Registered 2016-08-02.

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“…Curcumin use has been associated with improved glycemic control in animal models, 22 and human studies. 23…”

Section: Methodsmentioning

confidence: 99%

Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease-1: Study Protocol for a Multicenter Clinical Trial

Weir

Walsh

Cuerden

et al. 2018

Can J Kidney Health Dis

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Background:The progression to end-stage renal disease (ESRD) is the most important complication of chronic kidney disease (CKD). Patients with ESRD require dialysis or transplantation to survive, incur numerous complications, and have high mortality rates. Slowing the progression of CKD is an important goal. Unfortunately, even when current treatments are appropriately applied, patients with CKD still progress to ESRD. Current treatments do not address the inflammation and fibrosis that mediate progression to ESRD, but micro-particle curcumin, a natural health product, has both anti-inflammatory and anti-fibrotic properties and may be an effective treatment for patients with CKD.Objective:Micro-particle curcumin for the treatment of CKD-1 (MPAC-CKD-1) will measure the effect of micro-particle curcumin on 2 important markers of CKD progression: albuminuria and estimated glomerular filtration rate (eGFR). Efficacy in either of these markers will justify a larger, international trial to investigate micro-particle curcumin’s ability to lower the risk of ESRD in patients with CKD.Design:MPAC-CKD-1 is a multicenter, double-blind prospective randomized controlled trial.Setting:Four kidney disease clinics in Ontario, Canada (3 in London and 1 in Hamilton).Patients:We will enroll patients with CKD, defined by an eGFR between 15 and 60 mL/min/1.73 m2 and a daily albumin excretion of more than 300 mg (or a random urine sample albumin-to-creatinine ratio more than 30 mg/mmol).Measurements:We will measure changes in the co-primary outcomes of urinary albumin-to-creatinine ratio and eGFR at 3 months and 6 months. We will also measure compliance, safety parameters, and changes in health-related quality of life.Methods:Participants will be randomly assigned to receive micro-particle curcumin 90 mg once daily or matching placebo for 6 months. We will enroll at least 500 patients to exclude clinically meaningful 6-month changes in these 2 co-primary outcomes (16% difference in albuminuria, and a 2.3 mL/min/1.73 m2 between-group difference in the 6-month change in eGFR, at a two-tailed alpha of 0.025, power of 0.80).Results:Patient enrollment began on October 1, 2015, with 414 participants randomized as of July 2018. We expect to report the results in 2020.Limitations:MPAC-CKD-1 is not powered to assess outcomes such as the need for renal replacement therapy or death.Conclusions:MPAC-CKD-1 is a multicenter, double-blind prospective randomized controlled trial designed to test whether micro-particle curcumin reduces albuminuria and slows eGFR decline in patients with albuminuric CKD. MPAC-CKD-1 will also test the feasibility of this intervention and inform the need for a future larger scale trial (MPAC-CKD-2).Trial registration:MPAC-CKD-1 is registered with U.S. National Institutes of Health at clinicaltrials.gov (NCT02369549). Protocol version 2.0, December 6, 2014.

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Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: Systematic review and meta-analysis of randomized controlled trials

Cited by 45 publications

References 35 publications

Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study

Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study

Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial

Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease-1: Study Protocol for a Multicenter Clinical Trial

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