2018
DOI: 10.1177/2054358118813088
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Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease-1: Study Protocol for a Multicenter Clinical Trial

Abstract: Background:The progression to end-stage renal disease (ESRD) is the most important complication of chronic kidney disease (CKD). Patients with ESRD require dialysis or transplantation to survive, incur numerous complications, and have high mortality rates. Slowing the progression of CKD is an important goal. Unfortunately, even when current treatments are appropriately applied, patients with CKD still progress to ESRD. Current treatments do not address the inflammation and fibrosis that mediate progression to … Show more

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Cited by 14 publications
(9 citation statements)
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“…Participants were randomly assigned to receive micro-particle curcumin 90 mg once daily or a matching placebo for 6 months. As we mentioned above, due to its antioxidant and antiinflammatory potential micro-particle curcumin showed promising results in the treatment of CKD (Weir et al, 2018;Nowak et al, 2022) Advanced glycation end products (AGEs) play a significant role in the generation of ROS and proinflammatory cytokines in diabetes, ultimately leading to renal damage. RAGE-AGE activation in the kidney causes fibrotic response via activating intracellular pathways such as NF-lB, MAPK/ERK and phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) pathway (Nowotny et al, 2015).…”
Section: Peroxisome Proliferator-activated Receptor Gamma Natural Ago...mentioning
confidence: 99%
“…Participants were randomly assigned to receive micro-particle curcumin 90 mg once daily or a matching placebo for 6 months. As we mentioned above, due to its antioxidant and antiinflammatory potential micro-particle curcumin showed promising results in the treatment of CKD (Weir et al, 2018;Nowak et al, 2022) Advanced glycation end products (AGEs) play a significant role in the generation of ROS and proinflammatory cytokines in diabetes, ultimately leading to renal damage. RAGE-AGE activation in the kidney causes fibrotic response via activating intracellular pathways such as NF-lB, MAPK/ERK and phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) pathway (Nowotny et al, 2015).…”
Section: Peroxisome Proliferator-activated Receptor Gamma Natural Ago...mentioning
confidence: 99%
“…As curcumin decreases the release of gut bacteria-derived LPS and stimulates intestinal alkaline phosphatase and tight junction proteins 210 , beneficial effects on the intestinal barrier function 266 Recently, no effect for prophylactic curcumin given before contrast infusion was reported in a randomized trial of 60 high risk patients aimed at reducing contrast-induced nephropathy 267 . The Renal Community now awaits the results from an ongoing multicenter, double-blind prospective randomized controlled trial that studies whether microparticulate curcumin reduces albuminuria and slows the decline of renal function in CKD 268 .…”
Section: Nutrients That Target the Nrf2 Pathwaymentioning
confidence: 99%
“…Nevertheless, long-term tests with higher doses of turmeric are required to elucidate its outcomes on the renal function of such patients and the rate of development of CKD of different origins [17]. However, further research is recommended to evaluate the short-and long-term safety and efficacy of curcumin in this study group [98].…”
Section: Curcuminmentioning
confidence: 99%