Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies

Abstract

Curcumin is a poorly water-soluble drug that is used for the treatment of inflammations, tumors, wound healing antioxidant and other diseases. In the current manuscript, it is successfully formulated into proniosome gels. The proniosomes are readily hydrated into niosomal formulations using warm water. Proniosomes were prepared using nonionic surfactants (tween 80, span 60) either solely or in combinations with cholesterol. The produced niosomal formulations were homogenous in size with vesicular sizes >343 and <1800 nm. The encapsulation efficiency percentage “EE%” of curcumin in niosomal formulations was different according to niosomal composition. It increased up to 99.74% in formulations of tween 80/Chol of 200 μmole/mL lipid concentration. Span 60/chol niosomes showed decreased curcumin EE%. Niosomal formulations showed increased SSTF and PC with enhancement ratios of more than 20-fold compared with curcumin suspension form. Kinetically, niosomes fitted to the Korsemeyer-Peppas model with non-Fickian transport according to their calculated n-values where curcumin suspension form showed Korsemeyer-Peppas kinetics with Fickian transport. Niosomal formulations deposited higher curcumin amounts in the skin compared with the suspension form. The best niosomal formulation (F9) was used for niosomal gel and emulgel fabrication. Finally, the anti-inflammatory activity of curcumin in various formulations was evaluated using a rat hind paw edema method and the % of swelling was 17.5% following 24 h in group treated with curcumin niosomal emulgel. In conclusion, this study suggests that the developed niosomal emulgel could significantly enhance the anti-inflammatory effect of curcumin and be an efficient carrier for the transdermal delivery of the drug.

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

“…The anti-inflammatory influence of Brucine encapsulated into liposomal emulgel was appraised using male Wistar rats that went through a carrageenan-induced rat hind paw edema protocol as conducted previously by Shehata et al [ 58 ]. Edema was initiated into the rat hind paw 30 min prior to the commencement of the study using subcutaneous injection of 0.5% w/v carrageenan in saline into the left hind paw [ 59 ].…”

Lipid-Based Nanovesicular Drug Delivery Systems

“…Niosomes and proniosomes are LNV systems characterized by distinctive amphiphilic structures able to improve poorly soluble drugs bioavailability. Their uniqueness is in having a nonionic surfactant backbone while their multilamellar and unilamellar vesicles structures appear similar to that of liposomes [6] (Figures 1 and 2).…”

Enhancement of Anti-Inflammatory Activity of Optimized Niosomal Colchicine Loaded into Jojoba Oil-Based Emulgel Using Response Surface Methodology

“…First order kinetic C = C0 × ekt; c. Higuchi kinetic C = k × t 0.5 ; d. Korsmeyer-Peppas kinetic C = k × tn; where (C) represents the amount of colchicine released in time (t). (C0) indicates the value of (C) at time zero; (k) is the release constant; and (n) indicates the permeation rate exponent [ 52 ].…”

“…The action of colchicine as anti-inflammatory drug loaded into different formulations was evaluated via carrageenan-induced rat hind paw edema method. About 0.1 mL of 1% carrageenan in saline was injected subcutaneously into the left hind paw for edema induction, half an hour earlier to drug application [ 52 ]. Thirty six male Wister rats were allocated to six groups, each containing five rats of well-adjusted weight, and all groups were induced with inflammation as follows: Group I: control group that did not receive any treatment.…”