Curcumin modulates the angiogenic potential of human endothelial cells via FAK/P-38 MAPK signaling pathway

Hosseini, Abdolkarim; Rasmi, Yousef; Rahbarghazi‬, Reza; Aramwit, Pornanong; Daeihassani, Behrokh; Saboory, Ehsan

doi:10.1016/j.gene.2018.11.062

Cited by 25 publications

(22 citation statements)

References 25 publications

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“…Experimental data showed the pro-angiogenic capacity of some specific types of phytochemicals; for example, icariin is able to induce angiogenesis through activating the MEK/ERK-and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells [153]. However, it should be highlighted that some of the phytochemicals (e.g., curcumin) showed pro-or anti-angiogenic activities in a dose-dependent manner [154][155][156]. To date, a series of studies have shown the usability of phytochemical-incorporated electrospun nanofibers regarding pro-angiogenic strategies [43,157].…”

Section: Nanofibers Incorporating Phytochemicals and Other Bioactive mentioning

confidence: 99%

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

et al. 2020

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Angiogenesis (or the development of new blood vessels) is a key event in tissue engineering and regenerative medicine; thus, a number of biomaterials have been developed and combined with stem cells and/or bioactive molecules to produce three-dimensional (3D) pro-angiogenic constructs. Among the various biomaterials, electrospun nanofibrous scaffolds offer great opportunities for pro-angiogenic approaches in tissue repair and regeneration. Nanofibers made of natural and synthetic polymers are often used to incorporate bioactive components (e.g., bioactive glasses (BGs)) and load biomolecules (e.g., vascular endothelial growth factor (VEGF)) that exert pro-angiogenic activity. Furthermore, seeding of specific types of stem cells (e.g., endothelial progenitor cells) onto nanofibrous scaffolds is considered as a valuable alternative for inducing angiogenesis. The effectiveness of these strategies has been extensively examined both in vitro and in vivo and the outcomes have shown promise in the reconstruction of hard and soft tissues (mainly bone and skin, respectively). However, the translational of electrospun scaffolds with pro-angiogenic molecules or cells is only at its beginning, requiring more research to prove their usefulness in the repair and regeneration of other highly-vascularized vital tissues and organs. This review will cover the latest progress in designing and developing pro-angiogenic electrospun nanofibers and evaluate their usefulness in a tissue engineering and regenerative medicine setting.

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Section: Nanofibers Incorporating Phytochemicals and Other Bioactive mentioning

confidence: 99%

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

et al. 2020

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“…FAK activation regulates VEGF-induced control of angiogenesis (Hosseini et al, 2019) and c-Src phosphorylation is implicated in the angiogenic functions of EPCs (Di et al, 2013). In this study, we found that glucocerebroside reduced FAK and c-Src phosphorylation, suggesting that the FAK and c-Src pathways mediate the inhibitory effects of glucocerebroside.…”

Section: Discussionmentioning

confidence: 55%

Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis

Lee

Wang

et al. 2019

Food and Agricultural Immunology

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The recruitment of bone marrow-derived endothelial progenitor cells (EPCs) facilitates physiological and pathological processes involved in new blood vessel synthesis. Glucocerebroside, an extract of Cordyceps militaris, inhibits inflammatory cytokine production and monocyte migration, although its anti-angiogenic properties in human EPCs has remained largely unknown up until now. We describe how glucocerebroside reduces migration as well as tube formation induced by vascular endothelial growth factor (VEGF) stimulation in human EPCs, without affecting cell viability. This inhibitory effect was achieved through the focal adhesion kinase (FAK)/c-Src pathways. We also found that glucocerebroside reduced VEGFpromoted upregulation of the transcription factor Runx2 in the EPCs. The in vivo chick embryo chorioallantoic membrane model demonstrated that glucocerebroside reduces new vessel formation. Our investigation is the first to show that glucocerebroside reduces angiogenesis in human EPCs and to describe the underlying mechanisms. Further investigations are needed to examine the effects of glucocerebroside in other angiogenesis-related disorders. ARTICLE HISTORY

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“…VEGFR2 can upregulate both Akt and MAPK signaling pathways by endocytosis. The actin cytoskeleton was remodeled through the VEGF and gave rise to p38 activation, which is a MAPK that promoted the EC migration (Hosseini et al, ). PLCγ combined with phosphorylated tyrosine, which mediated the MAPK activation and induced a cascade reaction.…”

Section: Discussionmentioning

confidence: 99%

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

Tan

Cui

Zeng

et al. 2020

J Biomedical Materials Res

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The rapid re‐endothelialization of the vascular stent surface is desirable for preventing thrombosis or reducing restenosis. Many biological factors that promote the biological behavior of endothelial cells have been used for the surface modification of stents. Vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, induces strong vascular growth. In this study, we investigated different VEGF concentrations (50 to 500 ng/ml) to determine the optimum concentration for biocompatibility. First, VEGF‐loaded heparin/poly‐l‐lysine (Hep‐PLL) nanoparticles were created by electrostatic interactions. Then, the VEGF‐loaded nanoparticles were immobilized on dopamine‐coated 316 L stainless steel (SS) surfaces. The physical and chemical properties of the modified surface were characterized and the biocompatibility was evaluated in vitro. The results indicated that the VEGF‐loaded nanoparticles were immobilized successfully on the 316LSS surface, as evidenced by the results of Alcian Blue staining and water contact angle (WCA) measurements. The low platelet adhesion and activation indicated that the modified surfaces had good blood compatibility. The modified surfaces showed a good inhibitory effect on smooth muscle cells, indicating that they inhibited tissue hyperplasia. In addition, the modified surfaces significantly promoted endothelial cell adhesion, proliferation, migration, and biological activity, especially VEGF concentration was 350 ng/ml (NPV350). The optical VEGF concentration of the surface modified Hep‐PLL nanoparticles was 350 ng/ml. The proposed method shows promise for potential applications for cardiovascular devices.

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Curcumin modulates the angiogenic potential of human endothelial cells via FAK/P-38 MAPK signaling pathway

Cited by 25 publications

References 25 publications

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

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