Curcumin-loaded redox response  of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy

Zhao, Shuang; Ma, Litao; Cao, Chengwen; Yu, Qianqian; Chen, Lanmei; Liu, Jie

doi:10.2147/ijn.s123190

Cited by 38 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…41 The rapid action of ST can be translated in a longer anti-nociceptive effect by combination with nonsteroidal anti-inflammatory drugs like naproxen due to a longer effect on the inflammatory process. 42 The effect of liposomal curcumin Due to curcumin's anti-inflammatory 43 and antioxidative properties 7 as well as its lack of toxicity and neuroprotective effect, 44 we investigated the combination of the rapid effect of ST on the nociception process with the effects of curcumin in parenteral administration.…”

Section: Discussionmentioning

confidence: 99%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

View full text Add to dashboard Cite

BackgroundCurcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways. We aimed to assess the efficacy of liposomal curcumin compared with curcumin solution, when in addition to sumatriptan (ST) treatment, in an experimental migraine model induced with nitroglycerin (NTG) in rats.MethodsSeven groups of 9 rats each were investigated: control group without migraine (1 mL saline solution intraperitoneal injection [ip]), control group with induced migraine, NTG+ST group (ST), NTG+ST+curcumin1 (CC1) group – 1 mg/100 g body weight (bw), NTG+ST+CC2 – 2 mg/100 g bw, NTG+ST+liposomal curcumin1 (lCC1) group – 1 mg/100 g bw, and NTG+ST+lCC2 (lCC2) group – 2 mg/100 g bw. NTG and ST were administered as 1 mL ip NTG | 1 mg/100 g bw and 1 mL ip ST | 1 mg/100 g bw, respectively. Plasma total oxidative stress (TOS), malondialdehyde (MDA), nitric oxide (NOx), thiol levels, as well as total antioxidative capacity (TAC) were assessed. The nociception process was assessed by counting the number of flinches and shakes after the formalin test.ResultsThe plasma TOS, MDA, and NOx levels, as oxidative stress parameters, were significantly decreased in the curcumin-treated groups, especially where curcumin was in liposomal form. The thiol and TAC were also improved by the curcumin treatment, with the best results obtained for the liposomal curcumin. The closest number of flinches and shakes to the control group was obtained for the group treated with liposomal curcumin at a dose of 2 mg/100 g bw.ConclusionLiposomal curcumin in a dose of 2 mg/100 g bw when in addition to ST treatment could be an optimum therapeutic strategy for migraine attacks and could represent a base for future clinical research and application.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…Curcumin, extracted from the rhizome of the Curcuma longa Linnéa, is one of the polyphenolic flavonoid which mainly constituent by turmeric. Curcumin has plenty of biological functions, such as antioxidant, anti-inflammatory, anti-tumorigenic activities [ 8 , 9 ]. However, there has been no research to explore whether curcumin is beneficial for ischemia/reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Curcumin attenuates myocardial ischemia-reperfusion injury

et al. 2017

View full text Add to dashboard Cite

BackgroundCardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.MethodsOur study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.Results and ConclusionsThe inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.

show abstract

“…Curcumin encapsulated in monomethoxy-polyethylene glycol-chitosan-S-S-hexadecyl micelles effectively promoted the accumulation of active substances in cells and significantly down-regulated the expression of tumor necrosis factor. In addition, the nanoparticles also showed good anti-inflammatory effects in the tumor microenvironment [ 267 ]. Compared with free doxorubicin, doxorubicin/curcumin colloidal nanoparticles in human liver cancer SMMC 7721 cells exhibit prolonged release, a higher rate of cell apoptosis, and a stronger anti-angiogenesis effect [ 268 ].…”

Section: Nanoformulations For Loading and Delivery Of Polyphenolsmentioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

View full text Add to dashboard Cite

Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.

show abstract

Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy

Cited by 38 publications

References 30 publications

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Curcumin attenuates myocardial ischemia-reperfusion injury

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Contact Info

Product

Resources

About