Curcumin-loaded porous scaffold: an anti-angiogenic approach to inhibit endochondral ossification

Zhou, Jianwei

doi:10.1080/09205063.2023.2231663

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Studies have shown its potential to promote cartilage regeneration by stimulating the differentiation of endogenous bone marrow stem cells (BMSCs) [ 22 ]. Gelatin (GT), derived from collagen, is considered an ideal carrier for drugs due to its biocompatibility, degradability and solubility in various solvents [ 23 ]. Therefore, KGN-loaded GT could be used as the core layer for chondrogenic induction.…”

Section: Introductionmentioning

confidence: 99%

Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis

Zhao,

Xu,

Shen

et al. 2024

Regenerative Biomaterials

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Cartilage tissue engineering offers hope for tracheal cartilage defect repair. Establishing an anti-inflammatory microenvironment stands as a prerequisite for successful tracheal cartilage restoration, especially in immunocompetent animals. Hence, scaffolds inducing an anti-inflammatory response before chondrogenesis are crucial for effectively addressing tracheal cartilage defects. Herein, we develop a shell-core structured PLGA@ICA-GT@KGN nanofilm using poly(lactic-co-glycolic acid) (PLGA) and icariin (ICA, an anti-inflammatory drug) as the shell layer and gelatin (GT) and Kartogenin (KGN, a chondrogenic factor) as the core via coaxial electrospinning technology. The resultant PLGA@ICA-GT@KGN nanofilm exhibited a characteristic fibrous structure and demonstrated high biocompatibility. Notably, it showcased sustained release characteristics, releasing ICA within the initial 0 to 15 days and gradually releasing KGN between 11 to 29 days. Subsequent in vitro analysis revealed the potent anti-inflammatory capabilities of the released ICA from the shell layer, while the KGN released from the core layer effectively induced chondrogenic differentiation of bone marrow stem cells (BMSCs). Following this, the synthesized PLGA@ICA-GT@KGN nanofilms were loaded with BMSCs and stacked layer by layer, adhering to a "sandwich model" to form a composite sandwich construct. This construct was then utilized to repair circular tracheal defects in a rabbit model. The sequential release of ICA and KGN facilitated by the PLGA@ICA-GT@KGN nanofilm established an anti-inflammatory microenvironment before initiating chondrogenic induction, leading to effective tracheal cartilage restoration. This study underscores the significance of shell-core structured nanofilms in temporally regulating anti-inflammation and chondrogenesis. This approach offers a novel perspective for addressing tracheal cartilage defects, potentially revolutionizing their treatment methodologies.

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Section: Introductionmentioning

confidence: 99%

Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis

Zhao,

Xu,

Shen

et al. 2024

Regenerative Biomaterials

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“…In real-world industrial production, many objects cannot be modeled as systems with affine forms; therefore, the control design of non-affine non-linear systems has always been a key problem [13][14][15][16][17]. Furthermore, due to the needs of some practical tasks, such as supersonic vehicles and magnetic levitation systems [18][19][20], theoretical research on nonaffine non-linear MASs is more meaningful and some non-affine non-linear MAS control methods have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Adaptive consensus tracking control of non-affine non-linear MASs based on Taylor decoupling technology and an event-triggered design strategy

2023

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This research paper studies the consensus tracking control problem for a class of uncertain non-affine non-linear multi-agent systems (MASs). First, different from the separation design scheme using the mean value theorem in previous works, this research paper not only uses the mean value theorem but also introduces the Taylor decoupling method to decouple the complex unknown non-affine structure. Second, to solve the difficulty of unknown non-linear functions in non-linear MASs, an intelligent technique based on neural networks was used. In addition, compared with the existing traditional event-triggered control strategy based on the relative threshold, an improved event-triggered control strategy based on the decreasing function of error variables was introduced to reduce the waste of unnecessary resources. The theoretical result shows that the whole closed-loop system is stable under the action of the proposed control protocol. Finally, the simulation experiment verifies the effectiveness of our control method.

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Scaffold providing spatial guidance enhances the healing of osteochondral defects and reduce adverse bone-cartilage crosstalk

Li,

Deng,

Zhao

et al. 2024

Materials & Design

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Curcumin-loaded porous scaffold: an anti-angiogenic approach to inhibit endochondral ossification

Cited by 3 publications

References 32 publications

Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis

Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis

Adaptive consensus tracking control of non-affine non-linear MASs based on Taylor decoupling technology and an event-triggered design strategy

Scaffold providing spatial guidance enhances the healing of osteochondral defects and reduce adverse bone-cartilage crosstalk

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