Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition

Rapalli, Vamshi Krishna; Kaul, Vedhant; Waghule, Tejashree; Gorantla, Srividya; Sharma, Swati; Roy, Aniruddha; Dubey, Sunil Kumar; Singhvi, Gautam

doi:10.1016/j.ejps.2020.105438

Cited by 110 publications

(40 citation statements)

References 53 publications

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“…Curcumin has shown promising antimicrobial effects against several pathogens, including bacteria, such as S. aureus , Pseudomonas aeruginosa , Salmonella paratyphi , Escherichia coli , Penicillium notatum , Bacillus subtilis , Aspergillus niger , and Mycobacterium tuberculosis , some fungi, virus, and even parasites (da Silva et al, 2018; Gera et al, 2017). An optimized formulation for curcumin loaded nanostructured lipid carriers for topical application need to have an optimal permeation and retention of curcumin in the skin layers and high antibacterial activity for safe topical application (Rapalli et al, 2020).…”

Section: Pharmacological Properties Of Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half‐life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

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Section: Pharmacological Properties Of Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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show abstract

“…This accumulation of curcumin in the epidermis might be attributed to that the uppermost layer of the epidermis i.e., stratum corneum consists of 70% proteins, 15% lipids and 15% water and this composition of the epidermis affirm retention of intact LPHNPs from which curcumin is released slowly in the epidermal site of skin where involving the hyper-proliferation of keratinocytes and psoriasis. Hence, observed results manifested that NLHG-1 hydrogels were suitable for further in vivo study [81,82].…”

Section: In Vitro Skin Permeation Studiesmentioning

confidence: 75%

Boosting the Skin Delivery of Curcumin Through Stearic Acid-Ethyl Cellulose Blend Hybrid Nanocarriers-Based Approach for Mitigating Psoriasis

Jaiswal

Das

2021

Int J App Pharm

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Objective: Curcumin presents poor topical bioavailability when administered orally, which poses a major hurdle in its use as an effective therapy for the management of psoriasis. The present study reports the utilization of lipid-polymer hybrid nanoparticles (LPHNPs) for the topical delivery of curcumin which can be a potential approach for mitigating psoriasis. Methods: Curcumin-loaded LPHNPs were prepared by the emulsification solvent evaporation method and characterized. The optimized Curcumin-loaded LPHNPs (DLN-3) were further incorporated into 2% Carbopol 940 gels and evaluated for its therapeutic efficacy in the Imiquimod (IMQ)-induced psoriasis rat model. Results: The average particle size, polydispersity index, zeta potential, drug entrapment and loading efficiency for DLN-3 were found to be 200.9 nm, 0.342,-28.3 mV, 87.40±0.99% and 4.57±0.04%, respectively. FT-IR, DSC and XRD studies confirmed that all the components used for the formulation are compatible with each other, whereas SEM and TEM analysis affirmed the spherical shape of LPHNPs with a smooth surface. The in vitro drug release studies suggest that curcumin was released from the LPHNPs in a sustained manner over a period of 24 h via super case II transport mechanism. Results of in vitro skin permeation study revealed that 38.39±2.67% of curcumin permeated at 12 h across excised pig ear skin with a permeation flux of 18.74±3.59 µg/cm2/h. Further, in vivo evaluation and histopathological studies demonstrated that NLHG-1 hydrogels showed better therapeutic efficacy against the psoriatic skin lesions than the standard marketed gels. Conclusion: These results suggest that the developed LPHNPs have a superior ability to improve the skin penetration or accumulation of DLN-3 within psoriatic skin and offer a potential delivery system for the management of psoriasis.

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“…It belongs to the family Zingiberaceae (Rapalli, Kaul, Gorantla, et al, 2020). The rhizomes of turmeric are used to extract sesquiterpenes, zingiberene, and curcuminoids (Figure 7), which are responsible for antiinflammatory activity (Rapalli et al, 2020; Sahu et al, 2011). The curcuminoids and volatile oils selectively inhibit phosphorylase kinase present in the epidermis, thus eliciting antiinflammatory action (Singh & Tripathy, 2014).…”

Section: Different Natural Sources For the Treatment Of Psoriasismentioning

confidence: 99%

Potential herbal constituents for psoriasis treatment as protective and effective therapy

Dabholkar

Rapalli

Singhvi

2020

Phytotherapy Research

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Psoriasis is a multifactorial and chronic skin disorder. It is a recurrent disease that requires incessant therapy. Psoriasis treatment includes topical and systemic routes using synthetic drugs that lead to severe unwanted adverse effects. Herbal therapy is widely used for thousands of years in countries like China and India. The use of herbal therapy in the developed region enhanced to a great extent and showed better efficacy towards psoriasis alone or as adjuvant to synthetic therapy. Herbal medicines have gained great attention in the treatment of psoriasis due to their lesser side effects compared to synthetic drugs. In this review, the various plant sources which have been found effective in psoriasis and can be used to develop novel therapeutics have been discussed. The mechanisms by which the phytoconstituents elicit antipsoriatic activity and various research studies that have proven the effectiveness of these natural products have also been compiled in this review.

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Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition

Cited by 110 publications

References 53 publications

Curcumin nanoformulations for antimicrobial and wound healing purposes

Curcumin nanoformulations for antimicrobial and wound healing purposes

Boosting the Skin Delivery of Curcumin Through Stearic Acid-Ethyl Cellulose Blend Hybrid Nanocarriers-Based Approach for Mitigating Psoriasis

Potential herbal constituents for psoriasis treatment as protective and effective therapy

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