Curcumin-Loaded Nanoemulsion for Better Cellular Permeation

Abstract

Curcumin nanoemulsion was prepared using coconut oil, Tween 80 (surfactant) and polyethylene glycol (co-solvent) with the addition of honey and glycerol as additives. The nanoemulsion was optimized and systematically characterized for transdermal delivery. Small particle size (15.92 nm), low polydispersity index (0.17) and slight acidic (pH 4.18) curcumin nanoemulsion was obtained without any chemical degradation based on the Fourier transform infrared (FTIR) spectrum. The incorporation of curcumin inside nanoglobul improved curcumin stability and skin permeability. Its high permeability can be seen from Nile dyed curcumin in different layers of skin through fluorescent imaging. The release kinetic of curcumin followed the Higuchi model, which explains why the skin permeation was a Fickian diffusion-controlled process because the Korsmeyer constant was proven to be 0.3 (<0.5). Nanoencapsulation slightly decreased the antioxidant capacity of curcumin for about 7.9% compared to its free counterpart. It showed low cytotoxicity (EC50 2.3552 µg/mL) to human skin fibroblasts. Cell death was noticed at a high concentration (2.5 µg/mL) of treatment. Curcumin was also found to promote wound closure at low concentration 0.1563 µg/mL and was comparable with the performance of ascorbic acid based on scratch assay. Therefore, this nutritious curcumin nanoemulsion is a promising transdermal delivery system for topical application.

Optimizing the Process Design of Oil-in-Water Nanoemulsion for Delivering Poorly Soluble Cannabidiol Oil

“…Arechabala et al tested various surfactants against normal human fibroblasts, and in their study, Tween 80 appeared to be the least cytotoxic [29]. It is successfully used in other nanoemulsions with no cytotoxic effect-with applications for skin [30,31] and food [32]. The CBD was evaluated by Petrosino et al in the HaCaT cell line-no effect was observed with 1, 5, 10, and 20 µM of CBD after 6, 12, and 24 h [33].…”

Exploitation of traditional healing properties, using the nanotechnology’s advantages: The case of curcumin

“…Among other actions known so far, CUR effectively promotes wound healing at low doses either free [ 39 ] or incorporated in nanocarriers [ 44 ] as it is involving in the proliferation and migration of fibroblasts that is initiated at the second phase of wound healing. The comparison of the action of CUR free or incorporated in nanocarriers was not reported previously.…”

Development and Characterization of Cinnamon Oil Salicylic Acid Blended Nanoemulsion (CSN) for topical Application

“…Separately, the CSN and the physical mixture were ground into powder and pressurized at a pressure of 5 tonnes for 5 min in a KBr press (Technosearch Instrument Mumbai, India) to form pellets or thin films, and FT-IR spectra were recorded in the wavelength range 4000-400 cm -1 for each. 18…”