Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing

Karri, Veera Venkata Satyanarayana Reddy; Kuppusamy, Gowthamarajan; Talluri, Siddhartha Venkata; Mannemala, Sai Sandeep; Radhakrishna, K.; Wadhwani, Ashish; Mulukutla, Shashank; Raju, Kalidhindi Rama Satyanarayana; Malayandi, Rajkumar

doi:10.1016/j.ijbiomac.2016.05.038

Cited by 286 publications

(184 citation statements)

References 47 publications

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“…Thus, LCN-based delivery systems of curcumin show significant promise for topical applications of curcumin. More recently, the use of curcumin-loaded chitosan nanoparticles [42], hyalusomes [36] and hydrogels [43] also show promise in the cutaneous usage of curcumin in the future.…”

Section: Phytochemicals and Traditional Therapies In Wound Healingmentioning

confidence: 99%

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Shah

Amini-Nik

2017

IJMS

116

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Historically, plant-based products have been the basis of medicine since before the advent of modern Western medicine. Wound dressings made of honey, curcumin and other phytochemical-rich compounds have been traditionally used. Recently, the mechanisms behind many of these traditional therapies have come to light. In this review, we show that in the context of wound healing, there is a global theme of anti-inflammatory and antioxidant phytochemicals in traditional medicine. Although promising, we discuss the limitations of using some of these phytochemicals in order to warrant more research, ideally in randomized clinical trial settings.

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Section: Phytochemicals and Traditional Therapies In Wound Healingmentioning

confidence: 99%

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Shah

Amini-Nik

2017

IJMS

116

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“…Due to its non-toxicity, biocompatibility and ability to promote cell proliferation [12,13,14,15], it is widely used in tissue engineering, drug delivery and wound dressing, etc. The alginate-based wound dressings could absorb water up to several times their own weight [16,17,18]. However, wound dressings with higher swelling behavior are required as reported in the literature to help hemostasis, autolytic debridement, increased collagenase production and the moisture content of necrotic wounds.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Properties of Alginate/Poly(γ-glutamic acid) Composite Microparticles

et al. 2017

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Alginate (Alg) is a renewable polymer with excellent hemostatic properties and biocapability and is widely used for hemostatic wound dressing. However, the swelling properties of alginate-based wound dressings need to be promoted to meet the requirements of wider application. Poly(γ-glutamic acid) (PGA) is a natural polymer with high hydrophility. In the current study, novel Alg/PGA composite microparticles with double network structure were prepared by the emulsification/internal gelation method. It was found from the structure characterization that a double network structure was formed in the composite microparticles due to the ion chelation interaction between Ca2+ and the carboxylate groups of Alg and PGA and the electrostatic interaction between the secondary amine group of PGA and the carboxylate groups of Alg and PGA. The swelling behavior of the composite microparticles was significantly improved due to the high hydrophility of PGA. Influences of the preparing conditions on the swelling behavior of the composites were investigated. The porous microparticles could be formed while compositing of PGA. Thermal stability was studied by thermogravimetric analysis method. Moreover, in vitro cytocompatibility test of microparticles exhibited good biocompatibility with L929 cells. All results indicated that such Alg/PGA composite microparticles are a promising candidate in the field of wound dressing for hemostasis or rapid removal of exudates.

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“…Fibrin [19] Collagen-GAG [20] Gelatin microcryogels [23] GAG [28] BLCC [29] Freeze-drying sponges pGIcNAc [18] Collagen sponge [27] Electrospun patches Collagen/PLGA [21] Silk fibroin [24] Biomaterials with controlledrelease of signaling molecules Nanoparticles loaded with GF/chemokines VEGF, bFGF nanoparticles in PEtU-PDMS/ fibrin [33] Curcumin loaded chitosan nanoparticles into collagen-alginate [36] With vectors encoding functional molecules AdeNOS in fibrin scaffold [37] Hyaluronic acid-MMP hydrogels with VEGF plasmids [34] GF/Chemokines preloadedd within Hydrogels Glucophage-loaded collagen/PLGA [21] Gelatin-PGA-based scaffold payload MCP-1 [35] healing benefit was associated with a more efficient vascular network. Breitbart et al seeded mouse dermal fibroblasts onto polyglycolic acid scaffold matrices, on which the cells were retrovirally transduced with the human platelet-derived growth factor B (PDGF-B) gene [28].…”

Section: High-water Content Hydrogelsmentioning

confidence: 99%

“…This scaffold induced complete re-epithelialization of the wound of diabetic mice, along with enhanced granulation tissue formation and collagen deposition [33]. Karri et al impregnated curcumin loaded chitosan nanoparticles into collagen-alginate scaffolds for treating diabetic wounds [36]. Breen et al developed a fibrin scaffold for delivery of adenovirus encoding endothelial nitric oxide synthase (AdeNOS) to the wound of diabetic rabbits [37].…”

Section: Biomaterials With Controlled-release Of Signaling Moleculesmentioning

confidence: 99%

“…However, the speed of vascularization of scaffolds, which occurred in vivo after implantation, might be insufficient to supply embedded cells within the first critical week. The level of tissue-induced molecular signals released from biomaterials is mainly dependent on the initial concentration and drops after implantation [36,37]. New strategies for in vivo vascularization before implantation and devices or systems for consistent releasing of tissue-inductive signals should be considered for future investigation.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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