The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Shah, Ahmed; Amini-Nik, Saeid

doi:10.3390/ijms18051068

Cited by 104 publications

(70 citation statements)

References 111 publications

(140 reference statements)

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“…Humane Wunden zeigen analog eine erhöhte Expression von β-Catenin und seiner Zielgene Fibronectin und MMP7 während der proliferativen Phase [40]. Während eine erhöhte β-Catenin-Aktivität während der proliferativen Phase für eine erfolgreiche Wundheilung von entscheidender Bedeutung ist, trägt eine verlängerte oder abweichende β-Catenin-Aktivität über die normalen Heilungsparameter hinaus zu übermäßiger Fibrose und Narbenbildung bei [41]. So weisen hypertrophe Narben und Keloide erhöhte β-Catenin-Spiegel auf.…”

Section: Proliferationunclassified

Wnt-Signalwege bei kutaner Wundheilung

Houschyar

Tapking

Puladi

et al. 2019

Handchir Mikrochir plast Chir

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ZusammenfassungDie menschliche Haut ist eine effiziente Barriere, die den Organismus vor Noxen schützt. Wunden zerstören diese Barriere. Die Wundheilung ist eine in Phasen ablaufende physiologische Regeneration des zerstörten Gewebes, die im Idealfall zum Verschluss einer Wunde, insbesondere durch Neubildung von Bindegewebe und Kapillaren, führt. Der Wnt-Signalweg ist eine im gesamten Tierreich stark konservierte Signaltransduktionskaskade, durch die grundlegende zelluläre Interaktionen in multizellulären Organismen gesteuert werden. Entsprechend werden durch den Wnt-Signalweg viele Prozesse, z. B. die Balance zwischen Proliferation und Differenzierung oder die Apoptose, koordiniert. Die Wnt-Signalisierung wird durch eine Wunde aktiviert und nimmt an jeder nachfolgenden Phase des Heilungsprozesses teil, beginnend mit der Entzündungskontrolle und des programmierten Zelltods bis zur Mobilisation von Stammzellen innerhalb der Wunde. Die endogene Wnt-Signalverstärkung stellt einen attraktiven therapeutischen Ansatz dar, um die Wiederherstellung von Hautwunden zu unterstützen, da die komplexen Mechanismen des Wnt-Signalwegs im Laufe der Jahre zunehmend verstanden wurden. In dieser Übersichtsarbeit werden die aktuellen Daten zusammengefasst, um die Rolle der Wnt-Signalgebung beim Wundheilungsprozess der Haut zu verdeutlichen.

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Section: Proliferationunclassified

Wnt-Signalwege bei kutaner Wundheilung

Houschyar

Tapking

Puladi

et al. 2019

Handchir Mikrochir plast Chir

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“…The effects of inflammation on wound healing are complex; appropriate inflammation is helpful for wound healing, but the inflammation caused by depression appears to have a negative effect on wound healing. This study observed that, during the healing process, inflammatory cytokines in the inflammatory responses were significantly elevated by depression.…”

Section: Discussionmentioning

confidence: 99%

“…Many clinical studies have also found that the presence of adverse emotions during treatment is unfavorable for wound healing, but no study has clarified the mechanism involved . The role of the inflammatory response in wound healing has long been recognized by clinicians . Therefore, this study aims to explore whether depression affects the healing of wounds via inflammation; we hope to explain the effects of adverse emotions on wound healing and the underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Effects of depression on healing and inflammatory responses of acute wounds in rats

Jian

Huang

Zhu

et al. 2019

Wound Repair Regeneration

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This study aimed to elucidate the effect of depression on the healing of acute wounds in rats. We hypothesized that depression would have negative effects on inflammation and wound healing and that antidepressant therapy would reverse these effects. This study included 100 rats randomly allocated into five groups: control group (CG), depression group (DG), pre-depression group (PDG), antidepressant group (AG), and preantidepressant group (PAG). Acute wounds were created on the rats' backs. The groups were subjected to no interventions (CG), aversive stimuli before (PDG) and after (DG) wound creation, and antidepressant treatment before (PAG) and after (AG) wound creation. On the day of wound creation and on days 3, 6, 9, and 12 after wound creation, observations of the wound area and degree of depression (evaluated using the sucrose preference test, open-field test, and weight change) were recorded. On days 6 and 12 after wound creation, venous serum and wound tissues were collected. Tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-10 levels were measured using the enzyme-linked immunosorbent assay. Results showed an initial increase followed by a decrease in the degree of depression in all groups except DG (continuous decline). The wound-healing rate was significantly lower in PDG and DG than in CG; it was higher in AG and PAG than in CG. DG and PDG had higher concentrations of inflammatory cytokines than CG, and AG and PAG had lower concentrations than CG. This indicates that the onset of depression delays the healing of acute wounds and aggravates the inflammatory response in rats. Antidepressant treatment counteracts both of these negative effects.

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“…These results showed that delay wound healing appeared in diabetic mice and con rmed that the model in this experiment was successfully prepared. Wound healing in DM mice can be improved by DE It has been reported that phytochemicals could play a role in wound healing 24 . In order to test whether DE can improve diabetic wound healing, excisional wounding were administration and topical use at day1.…”

Section: Delay Wound Healing Appeared Following Administration Of Stzmentioning

confidence: 99%

Dendrobium officinale Orchid Extract could improve wound healing in diabetic mice

Zhu¹,

Yu²,

Yang³

et al. 2020

Preprint

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Background In diabetes, delayed wound healing is one of the most prominent clinical manifestations and lacks satisfactory therapeutic schemes. Persistent inflammation impairs the healing process which occurs in the late phase of wound healing in diabetes mellitus (DM) mice. It has been report that dendrobium officinale (DE) could decrease inflammation and the NF-κB signaling pathway plays a critical role in regulated inflammation. The aim of the present study is to detect whether DE attenuated inflammation by NF-κB to accelerate wound healing in diabetes. Methods Mice were induced to diabetes by streptozocin (STZ) for 15 days. Two circular 8-mm full-thickness wounds were created on the back and then received DE treatment for 18 days. The percentage of wound healing, re-epithelialization and collagen deposition were calculation to evaluation the effect of DE on wound healing. The expression levels of interleukin (IL)- 1β and TNF-α in the wound site were determined by WB. Macrophage deposition and the type of macrophage were detected by WB and immunohistochemical staining. In addition, the expression of p65 was detected by WB. Results Herein, we observed that the late wound healing could be improved by dendrobium officinale orchid extract (DE) in streptozotocin (STZ)-induced DM mice. The accumulation of collagen was increased by DE treatment in the skin. We also found that the expression of pro-inflammation cytokines IL-1β, and TNF-α were inhibited by DE treatment in the skin wounds of DM mice. Furthermore, the macrophages accumulation which increased in diabetes wound site, were inhibited by DE treatment in the DM mice wound skin. And the CD163 which is a marker of type 2 macrophage was increased by DE treatment. Moreover, we confirmed that DE could decrease the expression of iNos which is a marker of type 1 macrophage by IHC in the skin wounds. And the levels of p65 and p65 phosphorylation were decreased by DE. Conclusions Wound healing can be improved by DE through NF-κB signaling pathway to attenuated inflammation in STZ-induced diabetic mice.

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The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Cited by 104 publications

References 111 publications

Wnt-Signalwege bei kutaner Wundheilung

Wnt-Signalwege bei kutaner Wundheilung

Effects of depression on healing and inflammatory responses of acute wounds in rats

Dendrobium officinale Orchid Extract could improve wound healing in diabetic mice

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The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

Cited by 104 publications

References 111 publications

﻿Wnt-Signalwege bei kutaner Wundheilung

﻿Wnt-Signalwege bei kutaner Wundheilung

Effects of depression on healing and inflammatory responses of acute wounds in rats

Dendrobium officinale Orchid Extract could improve wound healing in diabetic mice

Contact Info

Product

Resources

About

Wnt-Signalwege bei kutaner Wundheilung

Wnt-Signalwege bei kutaner Wundheilung